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View Protein Complex Details

Complex Overview

From Publication: Riffle <i>et al</i>. (2010) (Unpublished Data)
Notes: Complex predicted from the combined set of Gavin (2002), Gavin (2006), Ho (2002) and Krogan (2006); at p-value cutoff of 1E-7
Complex Size: 11 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
BRR2
  • U4/U6 x U5 tri-snRNP complex
  • U5 snRNP
  • RNA splicing
  • mRNA metabolic process
  • auxin biosynthetic process
  • mRNA processing
  • spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
  • ATP-dependent RNA helicase activity
  • PRP4
  • U4/U6 x U5 tri-snRNP complex
  • nuclear mRNA splicing, via spliceosome
  • molecular_function
  • PRP40
  • U1 snRNP
  • nuclear mRNA splicing, via spliceosome
  • RNA binding
  • PRP8
  • U4/U6 x U5 tri-snRNP complex
  • U5 snRNP
  • nuclear mRNA 3'-splice site recognition
  • nuclear mRNA splicing, via spliceosome
  • U5 snRNA binding
  • SMB1
  • U4/U6 x U5 tri-snRNP complex
  • U5 snRNP
  • U1 snRNP
  • nuclear mRNA splicing, via spliceosome
  • RNA binding
  • molecular_function
  • SMD1
  • commitment complex
  • U4/U6 x U5 tri-snRNP complex
  • U5 snRNP
  • U1 snRNP
  • nuclear mRNA splicing, via spliceosome
  • mRNA binding
  • SMD2
  • U4/U6 x U5 tri-snRNP complex
  • U5 snRNP
  • U1 snRNP
  • nuclear mRNA splicing, via spliceosome
  • RNA binding
  • molecular_function
  • SMD3
  • commitment complex
  • U4/U6 x U5 tri-snRNP complex
  • U5 snRNP
  • U1 snRNP
  • nuclear mRNA splicing, via spliceosome
  • mRNA binding
  • SMX3
  • U4/U6 x U5 tri-snRNP complex
  • U5 snRNP
  • U1 snRNP
  • nuclear mRNA splicing, via spliceosome
  • RNA binding
  • molecular_function
  • SNU114
  • U4/U6 x U5 tri-snRNP complex
  • U5 snRNP
  • generation of catalytic spliceosome for first transesterification step
  • nuclear mRNA splicing, via spliceosome
  • GTP binding
  • U5 snRNA binding
  • GTPase activity
  • SNU66
  • U4/U6 x U5 tri-snRNP complex
  • nuclear mRNA splicing, via spliceosome
  • RNA binding
  • molecular_function
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    U4/U6 x U5 tri-snRNP complex 2.6585E-23 11 32 10 6292
    small nuclear ribonucleoprotein complex 4.0524E-23 11 63 11 6292
    U5 snRNP 8.1485E-21 11 14 8 6292
    U1 snRNP 6.6008E-14 11 17 6 6292
    ribonucleoprotein complex 9.7932E-13 11 514 11 6292
    nuclear part 4.6103E-9 11 1103 11 6292
    macromolecular complex 3.5578E-7 11 1635 11 6292
    nucleus 4.1084E-6 11 2041 11 6292
    organelle part 1.4064E-5 11 2282 11 6292
    intracellular organelle part 1.4064E-5 11 2282 11 6292
    U2-type spliceosomal complex 1.8167E-4 11 12 2 6292
    commitment complex 1.8167E-4 11 12 2 6292
    spliceosomal complex 2.6406E-3 11 45 2 6292
    membrane-bounded organelle 3.5629E-3 11 3771 11 6292
    intracellular membrane-bounded organelle 3.5629E-3 11 3771 11 6292
    intracellular organelle 8.2563E-3 11 4070 11 6292
    organelle 8.2787E-3 11 4071 11 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    nuclear mRNA splicing, via spliceosome 8.2951E-21 11 99 11 6292
    RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 9.3204E-21 11 100 11 6292
    RNA splicing, via transesterification reactions 2.039E-20 11 107 11 6292
    RNA splicing 2.2776E-19 11 132 11 6292
    mRNA processing 1.5305E-18 11 156 11 6292
    mRNA metabolic process 5.1912E-17 11 213 11 6292
    RNA processing 3.3986E-14 11 380 11 6292
    RNA metabolic process 9.2688E-10 11 954 11 6292
    gene expression 2.4488E-8 11 1283 11 6292
    nucleic acid metabolic process 7.2197E-8 11 1415 11 6292
    nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 2.2108E-7 11 1566 11 6292
    cellular nitrogen compound metabolic process 8.537E-7 11 1770 11 6292
    nitrogen compound metabolic process 9.7232E-7 11 1791 11 6292
    cellular macromolecule metabolic process 1.4269E-5 11 2285 11 6292
    macromolecule metabolic process 1.9349E-5 11 2349 11 6292
    spliceosomal conformational changes to generate catalytic conformation 9.9377E-5 11 9 2 6292
    primary metabolic process 1.9438E-4 11 2896 11 6292
    cellular metabolic process 3.2347E-4 11 3033 11 6292
    ribonucleoprotein complex assembly 4.5856E-4 11 92 3 6292
    metabolic process 5.03E-4 11 3157 11 6292
    auxin biosynthetic process 1.7483E-3 11 1 1 6292
    auxin metabolic process 1.7483E-3 11 1 1 6292
    regulation of hormone levels 1.7483E-3 11 1 1 6292
    hormone metabolic process 1.7483E-3 11 1 1 6292
    hormone biosynthetic process 1.7483E-3 11 1 1 6292
    spliceosome conformational change to release U4 (or U4atac) and U1 (or U11) 1.7483E-3 11 1 1 6292
    cellular macromolecular complex assembly 3.3093E-3 11 182 3 6292
    nuclear mRNA 3'-splice site recognition 3.4937E-3 11 2 1 6292
    generation of catalytic spliceosome for first transesterification step 5.2364E-3 11 3 1 6292
    cellular macromolecular complex subunit organization 8.8966E-3 11 259 3 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    RNA binding 3.5245E-10 11 367 9 6292
    nucleic acid binding 7.1719E-8 11 666 9 6292
    U5 snRNA binding 2.779E-6 11 2 2 6292
    binding 2.3581E-5 11 1294 9 6292
    snRNA binding 2.771E-5 11 5 2 6292
    mRNA binding 1.6022E-3 11 35 2 6292

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle