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View Protein Complex Details

Complex Overview

From Publication: Riffle <i>et al</i>. (2010) (Unpublished Data)
Notes: Complex predicted from the combined set of Gavin (2002), Gavin (2006), Ho (2002) and Krogan (2006); at p-value cutoff of 1E-7
Complex Size: 18 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
BRR2
  • U4/U6 x U5 tri-snRNP complex
  • U5 snRNP
  • RNA splicing
  • mRNA metabolic process
  • auxin biosynthetic process
  • mRNA processing
  • spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
  • ATP-dependent RNA helicase activity
  • CUS1
  • U2 snRNP
  • spliceosome assembly
  • RNA binding
  • protein binding
  • DIB1
  • U4/U6 x U5 tri-snRNP complex
  • U5 snRNP
  • nuclear mRNA splicing, via spliceosome
  • molecular_function
  • HSH155
  • U2 snRNP
  • spliceosome assembly
  • mRNA binding
  • LEA1
  • cytoplasm
  • U2 snRNP
  • telomere maintenance
  • nuclear mRNA splicing, via spliceosome
  • RNA binding
  • molecular_function
  • PRP3
  • U4/U6 x U5 tri-snRNP complex
  • nuclear mRNA splicing, via spliceosome
  • molecular_function
  • PRP31
  • mitochondrion
  • U4/U6 x U5 tri-snRNP complex
  • nuclear mRNA splicing, via spliceosome
  • RNA binding
  • molecular_function
  • PRP4
  • U4/U6 x U5 tri-snRNP complex
  • nuclear mRNA splicing, via spliceosome
  • molecular_function
  • PRP6
  • U4/U6 x U5 tri-snRNP complex
  • nuclear mRNA splicing, via spliceosome
  • binding
  • molecular_function
  • PRP8
  • U4/U6 x U5 tri-snRNP complex
  • U5 snRNP
  • nuclear mRNA 3'-splice site recognition
  • nuclear mRNA splicing, via spliceosome
  • U5 snRNA binding
  • PRP9
  • U2 snRNP
  • nuclear mRNA splicing, via spliceosome
  • RNA binding
  • RSE1
  • U2 snRNP
  • spliceosome assembly
  • nuclear mRNA splicing, via spliceosome
  • U2 snRNA binding
  • SMB1
  • U4/U6 x U5 tri-snRNP complex
  • U5 snRNP
  • U1 snRNP
  • nuclear mRNA splicing, via spliceosome
  • RNA binding
  • molecular_function
  • SMD1
  • commitment complex
  • U4/U6 x U5 tri-snRNP complex
  • U5 snRNP
  • U1 snRNP
  • nuclear mRNA splicing, via spliceosome
  • mRNA binding
  • SMD2
  • U4/U6 x U5 tri-snRNP complex
  • U5 snRNP
  • U1 snRNP
  • nuclear mRNA splicing, via spliceosome
  • RNA binding
  • molecular_function
  • SMD3
  • commitment complex
  • U4/U6 x U5 tri-snRNP complex
  • U5 snRNP
  • U1 snRNP
  • nuclear mRNA splicing, via spliceosome
  • mRNA binding
  • SNU114
  • U4/U6 x U5 tri-snRNP complex
  • U5 snRNP
  • generation of catalytic spliceosome for first transesterification step
  • nuclear mRNA splicing, via spliceosome
  • GTP binding
  • U5 snRNA binding
  • GTPase activity
  • SNU71
  • U1 snRNP
  • nuclear mRNA splicing, via spliceosome
  • RNA binding
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    small nuclear ribonucleoprotein complex 7.1088E-38 18 63 18 6292
    U4/U6 x U5 tri-snRNP complex 5.1777E-25 18 32 12 6292
    ribonucleoprotein complex 1.9904E-20 18 514 18 6292
    U5 snRNP 2.1482E-18 18 14 8 6292
    nuclear part 2.1786E-14 18 1103 18 6292
    macromolecular complex 2.7221E-11 18 1635 18 6292
    U2 snRNP 1.3255E-10 18 13 5 6292
    U1 snRNP 6.3294E-10 18 17 5 6292
    nucleus 1.5028E-9 18 2041 18 6292
    organelle part 1.1294E-8 18 2282 18 6292
    intracellular organelle part 1.1294E-8 18 2282 18 6292
    membrane-bounded organelle 9.7936E-5 18 3771 18 6292
    intracellular membrane-bounded organelle 9.7936E-5 18 3771 18 6292
    intracellular organelle 3.879E-4 18 4070 18 6292
    organelle 3.8963E-4 18 4071 18 6292
    commitment complex 5.0164E-4 18 12 2 6292
    U2-type spliceosomal complex 5.0164E-4 18 12 2 6292
    spliceosomal complex 7.1157E-3 18 45 2 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    nuclear mRNA splicing, via spliceosome 6.905E-34 18 99 18 6292
    RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 8.4207E-34 18 100 18 6292
    RNA splicing, via transesterification reactions 3.1868E-33 18 107 18 6292
    RNA splicing 1.8857E-31 18 132 18 6292
    mRNA processing 4.6322E-30 18 156 18 6292
    mRNA metabolic process 1.6685E-27 18 213 18 6292
    RNA processing 7.778E-23 18 380 18 6292
    RNA metabolic process 1.5637E-15 18 954 18 6292
    gene expression 3.3762E-13 18 1283 18 6292
    nucleic acid metabolic process 1.9899E-12 18 1415 18 6292
    nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 1.2475E-11 18 1566 18 6292
    cellular nitrogen compound metabolic process 1.1435E-10 18 1770 18 6292
    nitrogen compound metabolic process 1.4154E-10 18 1791 18 6292
    cellular macromolecule metabolic process 1.1566E-8 18 2285 18 6292
    macromolecule metabolic process 1.9051E-8 18 2349 18 6292
    ribonucleoprotein complex assembly 1.3366E-7 18 92 6 6292
    spliceosome assembly 1.3998E-7 18 18 4 6292
    primary metabolic process 8.3514E-7 18 2896 18 6292
    cellular metabolic process 1.9237E-6 18 3033 18 6292
    metabolic process 3.9649E-6 18 3157 18 6292
    cellular macromolecular complex assembly 7.4975E-6 18 182 6 6292
    cellular macromolecular complex subunit organization 5.612E-5 18 259 6 6292
    macromolecular complex assembly 8.8608E-5 18 281 6 6292
    spliceosomal conformational changes to generate catalytic conformation 2.7502E-4 18 9 2 6292
    macromolecular complex subunit organization 3.3144E-4 18 357 6 6292
    ribonucleoprotein complex biogenesis 4.265E-4 18 374 6 6292
    cellular component assembly 4.9868E-4 18 385 6 6292
    cellular process 1.7601E-3 18 4426 18 6292
    regulation of hormone levels 2.8608E-3 18 1 1 6292
    spliceosome conformational change to release U4 (or U4atac) and U1 (or U11) 2.8608E-3 18 1 1 6292
    auxin biosynthetic process 2.8608E-3 18 1 1 6292
    auxin metabolic process 2.8608E-3 18 1 1 6292
    hormone metabolic process 2.8608E-3 18 1 1 6292
    hormone biosynthetic process 2.8608E-3 18 1 1 6292
    nuclear mRNA 3'-splice site recognition 5.7138E-3 18 2 1 6292
    generation of catalytic spliceosome for first transesterification step 8.5592E-3 18 3 1 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    RNA binding 4.837E-13 18 367 13 6292
    nucleic acid binding 9.7198E-10 18 666 13 6292
    snRNA binding 1.9594E-7 18 5 3 6292
    binding 3.0149E-7 18 1294 14 6292
    U5 snRNA binding 7.7306E-6 18 2 2 6292
    mRNA binding 1.2154E-4 18 35 3 6292
    U2 snRNA binding 2.8608E-3 18 1 1 6292

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle