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View Protein Complex Details

Complex Overview

From Publication: Riffle <i>et al</i>. (2010) (Unpublished Data)
Notes: Complex predicted from the combined set of Gavin (2002), Gavin (2006), Ho (2002) and Krogan (2006); at p-value cutoff of 1E-7
Complex Size: 17 proteins

Complex Member Proteins

Protein

 GO Cellular Component GO Biological Process GO Molecular Function
BRR2
  • U4/U6 x U5 tri-snRNP complex
  • U5 snRNP
    		•
  • RNA splicing
  • mRNA metabolic process
  • auxin biosynthetic process
  • mRNA processing
  • spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
    		•
  • ATP-dependent RNA helicase activity
    		•
    CUS1
  • U2 snRNP
    		•
  • spliceosome assembly
    		•
  • RNA binding
  • protein binding
    		•
    DIB1
  • U4/U6 x U5 tri-snRNP complex
  • U5 snRNP
    		•
  • nuclear mRNA splicing, via spliceosome
    		•
  • molecular_function
    		•
    HSH155
  • U2 snRNP
    		•
  • spliceosome assembly
    		•
  • mRNA binding
    		•
    LEA1
  • cytoplasm
  • U2 snRNP
    		•
  • telomere maintenance
  • nuclear mRNA splicing, via spliceosome
    		•
  • RNA binding
  • molecular_function
    		•
    PRP19
  • nucleus
  • cytoplasm
  • mitochondrion
  • spliceosomal complex
    		•
  • nuclear mRNA splicing, via spliceosome
  • ubiquitin-dependent protein catabolic process
    		•
  • ubiquitin-protein ligase activity
  • first spliceosomal transesterification activity
  • RNA binding
    		•
    PRP21
  • U2 snRNP
    		•
  • nuclear mRNA splicing, via spliceosome
    		•
  • RNA binding
    		•
    PRP3
  • U4/U6 x U5 tri-snRNP complex
    		•
  • nuclear mRNA splicing, via spliceosome
    		•
  • molecular_function
    		•
    PRP31
  • mitochondrion
  • U4/U6 x U5 tri-snRNP complex
    		•
  • nuclear mRNA splicing, via spliceosome
    		•
  • RNA binding
  • molecular_function
    		•
    PRP4
  • U4/U6 x U5 tri-snRNP complex
    		•
  • nuclear mRNA splicing, via spliceosome
    		•
  • molecular_function
    		•
    PRP6
  • U4/U6 x U5 tri-snRNP complex
    		•
  • nuclear mRNA splicing, via spliceosome
    		•
  • binding
  • molecular_function
    		•
    PRP8
  • U4/U6 x U5 tri-snRNP complex
  • U5 snRNP
    		•
  • nuclear mRNA 3'-splice site recognition
  • nuclear mRNA splicing, via spliceosome
    		•
  • U5 snRNA binding
    		•
    PRP9
  • U2 snRNP
    		•
  • nuclear mRNA splicing, via spliceosome
    		•
  • RNA binding
    		•
    RSE1
  • U2 snRNP
    		•
  • spliceosome assembly
  • nuclear mRNA splicing, via spliceosome
    		•
  • U2 snRNA binding
    		•
    SMB1
  • U4/U6 x U5 tri-snRNP complex
  • U5 snRNP
  • U1 snRNP
    		•
  • nuclear mRNA splicing, via spliceosome
    		•
  • RNA binding
  • molecular_function
    		•
    SMD3
  • commitment complex
  • U4/U6 x U5 tri-snRNP complex
  • U5 snRNP
  • U1 snRNP
    		•
  • nuclear mRNA splicing, via spliceosome
    		•
  • mRNA binding
    		•
    SNU114
  • U4/U6 x U5 tri-snRNP complex
  • U5 snRNP
    		•
  • generation of catalytic spliceosome for first transesterification step
  • nuclear mRNA splicing, via spliceosome
    		•
  • GTP binding
  • U5 snRNA binding
  • GTPase activity
    		•

    Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    		 P-value

    		 A

    		 B

    		 I

    		 T
    small nuclear ribonucleoprotein complex 2.1858E-32 17 63 16 6292
    U4/U6 x U5 tri-snRNP complex 4.6111E-20 17 32 10 6292
    ribonucleoprotein complex 2.513E-19 17 514 17 6292
    nuclear part 1.2588E-13 17 1103 17 6292
    U2 snRNP 2.4444E-13 17 13 6 6292
    U5 snRNP 4.2712E-13 17 14 6 6292
    macromolecular complex 1.0557E-10 17 1635 17 6292
    nucleus 4.6591E-9 17 2041 17 6292
    organelle part 3.129E-8 17 2282 17 6292
    intracellular organelle part 3.129E-8 17 2282 17 6292
    membrane-bounded organelle 1.6371E-4 17 3771 17 6292
    intracellular membrane-bounded organelle 1.6371E-4 17 3771 17 6292
    intracellular organelle 6.0057E-4 17 4070 17 6292
    organelle 6.0308E-4 17 4071 17 6292
    U1 snRNP 9.1252E-4 17 17 2 6292
    spliceosomal complex 6.3538E-3 17 45 2 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    		 P-value

    		 A

    		 B

    		 I

    		 T
    nuclear mRNA splicing, via spliceosome 5.284E-32 17 99 17 6292
    RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 6.3663E-32 17 100 17 6292
    RNA splicing, via transesterification reactions 2.2219E-31 17 107 17 6292
    RNA splicing 1.0289E-29 17 132 17 6292
    mRNA processing 2.0912E-28 17 156 17 6292
    mRNA metabolic process 5.3419E-26 17 213 17 6292
    RNA processing 1.3445E-21 17 380 17 6292
    RNA metabolic process 1.0472E-14 17 954 17 6292
    gene expression 1.6734E-12 17 1283 17 6292
    nucleic acid metabolic process 8.9319E-12 17 1415 17 6292
    nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 5.0536E-11 17 1566 17 6292
    cellular nitrogen compound metabolic process 4.0932E-10 17 1770 17 6292
    nitrogen compound metabolic process 5.0065E-10 17 1791 17 6292
    cellular macromolecule metabolic process 3.1999E-8 17 2285 17 6292
    macromolecule metabolic process 5.1262E-8 17 2349 17 6292
    ribonucleoprotein complex assembly 9.0163E-8 17 92 6 6292
    spliceosome assembly 1.0907E-7 17 18 4 6292
    primary metabolic process 1.8202E-6 17 2896 17 6292
    cellular metabolic process 4.0023E-6 17 3033 17 6292
    cellular macromolecular complex assembly 5.1207E-6 17 182 6 6292
    metabolic process 7.9234E-6 17 3157 17 6292
    cellular macromolecular complex subunit organization 3.874E-5 17 259 6 6292
    macromolecular complex assembly 6.1355E-5 17 281 6 6292
    macromolecular complex subunit organization 2.3194E-4 17 357 6 6292
    spliceosomal conformational changes to generate catalytic conformation 2.4464E-4 17 9 2 6292
    ribonucleoprotein complex biogenesis 2.9917E-4 17 374 6 6292
    cellular component assembly 3.5035E-4 17 385 6 6292
    cellular process 2.5051E-3 17 4426 17 6292
    regulation of hormone levels 2.7018E-3 17 1 1 6292
    spliceosome conformational change to release U4 (or U4atac) and U1 (or U11) 2.7018E-3 17 1 1 6292
    auxin biosynthetic process 2.7018E-3 17 1 1 6292
    auxin metabolic process 2.7018E-3 17 1 1 6292
    hormone metabolic process 2.7018E-3 17 1 1 6292
    hormone biosynthetic process 2.7018E-3 17 1 1 6292
    nuclear mRNA 3'-splice site recognition 5.3968E-3 17 2 1 6292
    cellular component biogenesis 7.4875E-3 17 694 6 6292
    generation of catalytic spliceosome for first transesterification step 8.0849E-3 17 3 1 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    		 P-value

    		 A

    		 B

    		 I

    		 T
    RNA binding 6.1856E-12 17 367 12 6292
    nucleic acid binding 6.7578E-9 17 666 12 6292
    snRNA binding 1.6332E-7 17 5 3 6292
    binding 1.1545E-6 17 1294 13 6292
    U5 snRNA binding 6.8716E-6 17 2 2 6292
    U2 snRNA binding 2.7018E-3 17 1 1 6292
    mRNA binding 3.8798E-3 17 35 2 6292
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle