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View Protein Complex Details

Complex Overview

From Publication: Riffle <i>et al</i>. (2010) (Unpublished Data)
Notes: Complex predicted from the combined set of Gavin (2002), Gavin (2006), Ho (2002) and Krogan (2006); at p-value cutoff of 1E-7
Complex Size: 19 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
RPL11B
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • ribosomal large subunit assembly
  • translation
  • structural constituent of ribosome
  • RPL12B, RPL12A
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • regulation of translation
  • translational termination
  • ribosomal large subunit assembly
  • translation
  • RNA binding
  • structural constituent of ribosome
  • RPL16A
  • ribonucleoprotein complex
  • cytoplasm
  • large ribosomal subunit
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • translation
  • RNA binding
  • structural constituent of ribosome
  • RPL18A, RPL18B
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • regulation of translation
  • translation
  • structural constituent of ribosome
  • RPL20A
  • translation
  • structural constituent of ribosome
  • RPL2A, RPL2B
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • regulation of translation
  • response to drug
  • translation
  • RNA binding
  • structural constituent of ribosome
  • rRNA binding
  • RPL3
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • ribosomal large subunit assembly
  • translation
  • structural constituent of ribosome
  • RPL30
  • cytoplasm
  • negative regulation of nuclear mRNA splicing, via spliceosome
  • rRNA processing
  • negative regulation of translation
  • translation
  • structural constituent of ribosome
  • RPL36A
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • translation
  • RNA binding
  • structural constituent of ribosome
  • RPL4A
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • translation
  • structural constituent of ribosome
  • RPL5
  • ribosomal large subunit assembly
  • translation
  • RNA binding
  • structural constituent of ribosome
  • RPS16B, RPS16A
  • ribonucleoprotein complex
  • cytosolic small ribosomal subunit
  • cytoplasm
  • ribosome
  • 90S preribosome
  • intracellular
  • regulation of translation
  • maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
  • ribosomal small subunit biogenesis
  • translation
  • structural constituent of ribosome
  • RPS17B
  • ribonucleoprotein complex
  • cytosolic small ribosomal subunit
  • cytoplasm
  • ribosome
  • intracellular
  • telomere maintenance
  • ribosomal small subunit assembly
  • translation
  • structural constituent of ribosome
  • RPS2
  • small nucleolar ribonucleoprotein complex
  • regulation of translational fidelity
  • translation
  • structural constituent of ribosome
  • RPS22A
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic small ribosomal subunit
  • ribosome
  • intracellular
  • telomere maintenance
  • translation
  • structural constituent of ribosome
  • RPS30B, RPS30A
  • stress granule
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic small ribosomal subunit
  • ribosome
  • intracellular
  • translation
  • structural constituent of ribosome
  • RPS5
  • ribonucleoprotein complex
  • cytosolic small ribosomal subunit
  • cytoplasm
  • small ribosomal subunit
  • 90S preribosome
  • ribosome
  • intracellular
  • translation
  • structural constituent of ribosome
  • RPS8B, RPS8A
  • ribonucleoprotein complex
  • cytosolic small ribosomal subunit
  • cytoplasm
  • 90S preribosome
  • ribosome
  • intracellular
  • regulation of translation
  • maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
  • translation
  • structural constituent of ribosome
  • RPS9B
  • small nucleolar ribonucleoprotein complex
  • regulation of translational fidelity
  • translation
  • structural constituent of ribosome
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    cytosolic ribosome 3.2432E-22 19 101 14 6292
    cytosolic part 5.3215E-21 19 122 14 6292
    ribosomal subunit 1.9334E-18 19 183 14 6292
    cytosol 1.0112E-15 19 284 14 6292
    ribosome 1.358E-15 19 290 14 6292
    ribonucleoprotein complex 2.4314E-15 19 514 16 6292
    cytosolic large ribosomal subunit 2.9396E-12 19 60 8 6292
    large ribosomal subunit 4.3513E-10 19 110 8 6292
    cytosolic small ribosomal subunit 8.2307E-10 19 38 6 6292
    non-membrane-bounded organelle 1.8386E-8 19 959 14 6292
    intracellular non-membrane-bounded organelle 1.8386E-8 19 959 14 6292
    small ribosomal subunit 4.7682E-8 19 73 6 6292
    macromolecular complex 1.7233E-7 19 1635 16 6292
    90S preribosome 1.546E-5 19 17 3 6292
    preribosome 1.317E-4 19 34 3 6292
    organelle part 9.9948E-4 19 2282 14 6292
    intracellular organelle part 9.9948E-4 19 2282 14 6292
    cytoplasmic part 2.5936E-3 19 2482 14 6292
    stress granule 3.0197E-3 19 1 1 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    translation 3.6523E-24 19 376 19 6292
    cellular protein metabolic process 2.2613E-15 19 1074 19 6292
    protein metabolic process 6.6265E-15 19 1136 19 6292
    cellular macromolecule biosynthetic process 1.5364E-14 19 1187 19 6292
    macromolecule biosynthetic process 1.5867E-14 19 1189 19 6292
    gene expression 6.8073E-14 19 1283 19 6292
    regulation of translation 1.9074E-12 19 57 8 6292
    cellular biosynthetic process 3.1157E-12 19 1567 19 6292
    posttranscriptional regulation of gene expression 3.378E-12 19 61 8 6292
    biosynthetic process 4.752E-12 19 1602 19 6292
    regulation of cellular protein metabolic process 8.3869E-12 19 68 8 6292
    regulation of protein metabolic process 1.694E-11 19 74 8 6292
    cellular macromolecule metabolic process 4.1791E-9 19 2285 19 6292
    macromolecule metabolic process 7.078E-9 19 2349 19 6292
    primary metabolic process 3.8309E-7 19 2896 19 6292
    ribosomal subunit assembly 4.492E-7 19 55 5 6292
    cellular metabolic process 9.2442E-7 19 3033 19 6292
    ribosome assembly 9.6814E-7 19 64 5 6292
    organelle assembly 1.4138E-6 19 69 5 6292
    metabolic process 1.9837E-6 19 3157 19 6292
    ribosome biogenesis 3.4183E-6 19 346 8 6292
    ribosomal large subunit assembly 5.6055E-6 19 41 4 6292
    ribonucleoprotein complex assembly 5.9261E-6 19 92 5 6292
    ribonucleoprotein complex biogenesis 6.1243E-6 19 374 8 6292
    regulation of gene expression 2.2168E-5 19 445 8 6292
    regulation of macromolecule biosynthetic process 2.6508E-5 19 456 8 6292
    regulation of cellular biosynthetic process 3.4092E-5 19 472 8 6292
    regulation of biosynthetic process 3.4621E-5 19 473 8 6292
    ribosomal large subunit biogenesis 3.5792E-5 19 65 4 6292
    regulation of macromolecule metabolic process 4.3436E-5 19 488 8 6292
    regulation of primary metabolic process 6.3208E-5 19 514 8 6292
    regulation of cellular metabolic process 8.5407E-5 19 536 8 6292
    regulation of metabolic process 9.876E-5 19 547 8 6292
    cellular macromolecular complex assembly 1.6023E-4 19 182 5 6292
    regulation of translational fidelity 3.0714E-4 19 9 2 6292
    cellular component biogenesis 5.2357E-4 19 694 8 6292
    maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) 6.607E-4 19 13 2 6292
    regulation of translational elongation 6.607E-4 19 13 2 6292
    cellular macromolecular complex subunit organization 8.2202E-4 19 259 5 6292
    biological regulation 1.1518E-3 19 1213 10 6292
    macromolecular complex assembly 1.1888E-3 19 281 5 6292
    cellular process 1.2366E-3 19 4426 19 6292
    regulation of cellular process 1.3244E-3 19 796 8 6292
    regulation of biological process 1.6662E-3 19 824 8 6292
    ribosomal small subunit biogenesis 2.6892E-3 19 26 2 6292
    negative regulation of mRNA processing 3.0197E-3 19 1 1 6292
    negative regulation of nuclear mRNA splicing, via spliceosome 3.0197E-3 19 1 1 6292
    negative regulation of RNA splicing 3.0197E-3 19 1 1 6292
    translational elongation 3.3414E-3 19 29 2 6292
    macromolecular complex subunit organization 3.431E-3 19 357 5 6292
    cellular component assembly 4.7538E-3 19 385 5 6292
    regulation of mRNA processing 6.0308E-3 19 2 1 6292
    regulation of RNA splicing 6.0308E-3 19 2 1 6292
    regulation of nuclear mRNA splicing, via spliceosome 6.0308E-3 19 2 1 6292
    rRNA processing 6.2791E-3 19 128 3 6292
    rRNA metabolic process 7.5796E-3 19 137 3 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    structural constituent of ribosome 4.7233E-29 19 212 19 6292
    structural molecule activity 4.8468E-25 19 339 19 6292
    RNA binding 3.8677E-3 19 367 5 6292

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle