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View Protein Complex Details

Complex Overview

From Publication: Riffle <i>et al</i>. (2010) (Unpublished Data)
Notes: Complex predicted from the combined set of Gavin (2002), Gavin (2006), Ho (2002) and Krogan (2006); at p-value cutoff of 1E-7
Complex Size: 15 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
RPL12B, RPL12A
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • regulation of translation
  • translational termination
  • ribosomal large subunit assembly
  • translation
  • RNA binding
  • structural constituent of ribosome
  • RPL17A
  • cytoplasm
  • translation
  • structural constituent of ribosome
  • RPL17B
  • ribonucleoprotein complex
  • cytoplasm
  • large ribosomal subunit
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • translation
  • structural constituent of ribosome
  • RPL20A
  • translation
  • structural constituent of ribosome
  • RPL21A
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • translation
  • structural constituent of ribosome
  • RPL26A
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • large ribosomal subunit
  • ribosome
  • intracellular
  • translation
  • RNA binding
  • structural constituent of ribosome
  • RPL2A, RPL2B
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • regulation of translation
  • response to drug
  • translation
  • RNA binding
  • structural constituent of ribosome
  • rRNA binding
  • RPL30
  • cytoplasm
  • negative regulation of nuclear mRNA splicing, via spliceosome
  • rRNA processing
  • negative regulation of translation
  • translation
  • structural constituent of ribosome
  • RPL32
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • translation
  • structural constituent of ribosome
  • RPL36A
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • translation
  • RNA binding
  • structural constituent of ribosome
  • RPL4A
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • translation
  • structural constituent of ribosome
  • RPS16B, RPS16A
  • ribonucleoprotein complex
  • cytosolic small ribosomal subunit
  • cytoplasm
  • ribosome
  • 90S preribosome
  • intracellular
  • regulation of translation
  • maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
  • ribosomal small subunit biogenesis
  • translation
  • structural constituent of ribosome
  • RPS17B
  • ribonucleoprotein complex
  • cytosolic small ribosomal subunit
  • cytoplasm
  • ribosome
  • intracellular
  • telomere maintenance
  • ribosomal small subunit assembly
  • translation
  • structural constituent of ribosome
  • RPS26B
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic small ribosomal subunit
  • ribosome
  • intracellular
  • translation
  • structural constituent of ribosome
  • RPS30B, RPS30A
  • stress granule
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic small ribosomal subunit
  • ribosome
  • intracellular
  • translation
  • structural constituent of ribosome
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    cytosolic ribosome 6.5551E-20 15 101 12 6292
    cytosolic part 7.0711E-19 15 122 12 6292
    ribosomal subunit 1.0798E-16 15 183 12 6292
    cytosol 2.2985E-14 15 284 12 6292
    ribosome 2.9604E-14 15 290 12 6292
    cytosolic large ribosomal subunit 2.5778E-13 15 60 8 6292
    ribonucleoprotein complex 2.8356E-11 15 514 12 6292
    large ribosomal subunit 3.9263E-11 15 110 8 6292
    non-membrane-bounded organelle 4.3033E-8 15 959 12 6292
    intracellular non-membrane-bounded organelle 4.3033E-8 15 959 12 6292
    cytosolic small ribosomal subunit 1.4725E-6 15 38 4 6292
    macromolecular complex 1.8508E-5 15 1635 12 6292
    small ribosomal subunit 2.067E-5 15 73 4 6292
    organelle part 6.8752E-4 15 2282 12 6292
    intracellular organelle part 6.8752E-4 15 2282 12 6292
    cytoplasmic part 1.6517E-3 15 2482 12 6292
    cytoplasm 2.3475E-3 15 3552 14 6292
    stress granule 2.384E-3 15 1 1 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    translation 3.3913E-19 15 376 15 6292
    cellular protein metabolic process 2.8044E-12 15 1074 15 6292
    protein metabolic process 6.5431E-12 15 1136 15 6292
    cellular macromolecule biosynthetic process 1.2694E-11 15 1187 15 6292
    macromolecule biosynthetic process 1.3021E-11 15 1189 15 6292
    gene expression 4.1034E-11 15 1283 15 6292
    cellular biosynthetic process 8.3612E-10 15 1567 15 6292
    biosynthetic process 1.1663E-9 15 1602 15 6292
    cellular macromolecule metabolic process 2.4475E-7 15 2285 15 6292
    macromolecule metabolic process 3.7086E-7 15 2349 15 6292
    regulation of translation 7.6721E-6 15 57 4 6292
    primary metabolic process 8.6423E-6 15 2896 15 6292
    posttranscriptional regulation of gene expression 1.0079E-5 15 61 4 6292
    regulation of cellular protein metabolic process 1.5575E-5 15 68 4 6292
    cellular metabolic process 1.7316E-5 15 3033 15 6292
    regulation of protein metabolic process 2.182E-5 15 74 4 6292
    metabolic process 3.1628E-5 15 3157 15 6292
    ribosomal small subunit biogenesis 1.6681E-3 15 26 2 6292
    negative regulation of mRNA processing 2.384E-3 15 1 1 6292
    negative regulation of nuclear mRNA splicing, via spliceosome 2.384E-3 15 1 1 6292
    negative regulation of RNA splicing 2.384E-3 15 1 1 6292
    regulation of mRNA processing 4.7627E-3 15 2 1 6292
    regulation of RNA splicing 4.7627E-3 15 2 1 6292
    regulation of nuclear mRNA splicing, via spliceosome 4.7627E-3 15 2 1 6292
    cellular process 5.0732E-3 15 4426 15 6292
    ribosomal subunit assembly 7.324E-3 15 55 2 6292
    ribosome biogenesis 7.5613E-3 15 346 4 6292
    ribosome assembly 9.8206E-3 15 64 2 6292
    ribonucleoprotein complex biogenesis 9.9288E-3 15 374 4 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    structural constituent of ribosome 5.0151E-23 15 212 15 6292
    structural molecule activity 6.9493E-20 15 339 15 6292
    RNA binding 9.2962E-3 15 367 4 6292

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle