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View Protein Complex Details

Complex Overview

From Publication: Riffle <i>et al</i>. (2010) (Unpublished Data)
Notes: Complex predicted from the combined set of Gavin (2002), Gavin (2006), Ho (2002) and Krogan (2006); at p-value cutoff of 1E-7
Complex Size: 13 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
RAD4
  • nucleotide-excision repair factor 2 complex
  • repairosome
  • nucleotide-excision repair, DNA damage recognition
  • damaged DNA binding
  • RPL12B, RPL12A
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • regulation of translation
  • translational termination
  • ribosomal large subunit assembly
  • translation
  • RNA binding
  • structural constituent of ribosome
  • RPL17A
  • cytoplasm
  • translation
  • structural constituent of ribosome
  • RPL17B
  • ribonucleoprotein complex
  • cytoplasm
  • large ribosomal subunit
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • translation
  • structural constituent of ribosome
  • RPL20A
  • translation
  • structural constituent of ribosome
  • RPL2A, RPL2B
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • regulation of translation
  • response to drug
  • translation
  • RNA binding
  • structural constituent of ribosome
  • rRNA binding
  • RPL3
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • ribosomal large subunit assembly
  • translation
  • structural constituent of ribosome
  • RPL36A
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • translation
  • RNA binding
  • structural constituent of ribosome
  • RPL42B, RPL42A
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • response to antibiotic
  • response to cycloheximide
  • translation
  • structural constituent of ribosome
  • RPL4A
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • translation
  • structural constituent of ribosome
  • RPS14A
  • small nucleolar ribonucleoprotein complex
  • maturation of SSU-rRNA
  • telomere maintenance
  • ribosomal small subunit assembly
  • translation
  • RNA binding
  • structural constituent of ribosome
  • RPS2
  • small nucleolar ribonucleoprotein complex
  • regulation of translational fidelity
  • translation
  • structural constituent of ribosome
  • RPS30B, RPS30A
  • stress granule
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic small ribosomal subunit
  • ribosome
  • intracellular
  • translation
  • structural constituent of ribosome
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    cytosolic ribosome 4.0135E-12 13 101 8 6292
    cytosolic large ribosomal subunit 8.211E-12 13 60 7 6292
    cytosolic part 1.8837E-11 13 122 8 6292
    ribosomal subunit 5.0006E-10 13 183 8 6292
    large ribosomal subunit 6.486E-10 13 110 7 6292
    ribonucleoprotein complex 2.7819E-9 13 514 10 6292
    cytosol 1.6525E-8 13 284 8 6292
    ribosome 1.9488E-8 13 290 8 6292
    macromolecular complex 1.6165E-5 13 1635 11 6292
    non-membrane-bounded organelle 1.7806E-4 13 959 8 6292
    intracellular non-membrane-bounded organelle 1.7806E-4 13 959 8 6292
    stress granule 2.0661E-3 13 1 1 6292
    nucleotide-excision repair factor 2 complex 4.1283E-3 13 2 1 6292
    repairosome 8.2408E-3 13 4 1 6292
    small nucleolar ribonucleoprotein complex 9.2843E-3 13 72 2 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    translation 2.1597E-14 13 376 12 6292
    cellular protein metabolic process 6.3767E-9 13 1074 12 6292
    protein metabolic process 1.2412E-8 13 1136 12 6292
    cellular macromolecule biosynthetic process 2.0887E-8 13 1187 12 6292
    macromolecule biosynthetic process 2.1308E-8 13 1189 12 6292
    gene expression 5.2425E-8 13 1283 12 6292
    cellular biosynthetic process 5.5313E-7 13 1567 12 6292
    biosynthetic process 7.1688E-7 13 1602 12 6292
    cellular macromolecule metabolic process 1.8698E-6 13 2285 13 6292
    macromolecule metabolic process 2.6802E-6 13 2349 13 6292
    primary metabolic process 4.1002E-5 13 2896 13 6292
    cellular metabolic process 7.4867E-5 13 3033 13 6292
    metabolic process 1.2617E-4 13 3157 13 6292
    ribosomal subunit assembly 1.6993E-4 13 55 3 6292
    regulation of translation 1.8907E-4 13 57 3 6292
    posttranscriptional regulation of gene expression 2.3144E-4 13 61 3 6292
    ribosome assembly 2.6697E-4 13 64 3 6292
    regulation of cellular protein metabolic process 3.1959E-4 13 68 3 6292
    organelle assembly 3.3372E-4 13 69 3 6292
    regulation of protein metabolic process 4.1043E-4 13 74 3 6292
    ribonucleoprotein complex assembly 7.7815E-4 13 92 3 6292
    response to cycloheximide 2.0661E-3 13 1 1 6292
    response to cycloalkane 2.0661E-3 13 1 1 6292
    response to organic cyclic substance 2.0661E-3 13 1 1 6292
    ribosomal large subunit assembly 3.088E-3 13 41 2 6292
    cellular macromolecular complex assembly 5.4966E-3 13 182 3 6292
    response to antibiotic 6.1865E-3 13 3 1 6292
    ribosomal large subunit biogenesis 7.6171E-3 13 65 2 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    structural constituent of ribosome 1.9879E-17 13 212 12 6292
    structural molecule activity 6.1449E-15 13 339 12 6292
    RNA binding 5.3427E-3 13 367 4 6292
    nucleic acid binding 8.1613E-3 13 666 5 6292

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle