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View Protein Complex Details

Complex Overview

From Publication: Riffle <i>et al</i>. (2010) (Unpublished Data)
Notes: Complex predicted from the combined set of Gavin (2002), Gavin (2006), Ho (2002) and Krogan (2006); at p-value cutoff of 1E-7
Complex Size: 20 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
RPL11B
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • ribosomal large subunit assembly
  • translation
  • structural constituent of ribosome
  • RPL12B, RPL12A
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • regulation of translation
  • translational termination
  • ribosomal large subunit assembly
  • translation
  • RNA binding
  • structural constituent of ribosome
  • RPL17A
  • cytoplasm
  • translation
  • structural constituent of ribosome
  • RPL17B
  • ribonucleoprotein complex
  • cytoplasm
  • large ribosomal subunit
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • translation
  • structural constituent of ribosome
  • RPL20A
  • translation
  • structural constituent of ribosome
  • RPL21A
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • translation
  • structural constituent of ribosome
  • RPL24A
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • translation
  • RNA binding
  • structural constituent of ribosome
  • RPL26A
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • large ribosomal subunit
  • ribosome
  • intracellular
  • translation
  • RNA binding
  • structural constituent of ribosome
  • RPL2A, RPL2B
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • regulation of translation
  • response to drug
  • translation
  • RNA binding
  • structural constituent of ribosome
  • rRNA binding
  • RPL3
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • ribosomal large subunit assembly
  • translation
  • structural constituent of ribosome
  • RPL30
  • cytoplasm
  • negative regulation of nuclear mRNA splicing, via spliceosome
  • rRNA processing
  • negative regulation of translation
  • translation
  • structural constituent of ribosome
  • RPL32
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • translation
  • structural constituent of ribosome
  • RPL36A
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • translation
  • RNA binding
  • structural constituent of ribosome
  • RPL4A
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • translation
  • structural constituent of ribosome
  • RPS14A
  • small nucleolar ribonucleoprotein complex
  • maturation of SSU-rRNA
  • telomere maintenance
  • ribosomal small subunit assembly
  • translation
  • RNA binding
  • structural constituent of ribosome
  • RPS16B, RPS16A
  • ribonucleoprotein complex
  • cytosolic small ribosomal subunit
  • cytoplasm
  • ribosome
  • 90S preribosome
  • intracellular
  • regulation of translation
  • maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
  • ribosomal small subunit biogenesis
  • translation
  • structural constituent of ribosome
  • RPS17B
  • ribonucleoprotein complex
  • cytosolic small ribosomal subunit
  • cytoplasm
  • ribosome
  • intracellular
  • telomere maintenance
  • ribosomal small subunit assembly
  • translation
  • structural constituent of ribosome
  • RPS2
  • small nucleolar ribonucleoprotein complex
  • regulation of translational fidelity
  • translation
  • structural constituent of ribosome
  • RPS30B, RPS30A
  • stress granule
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic small ribosomal subunit
  • ribosome
  • intracellular
  • translation
  • structural constituent of ribosome
  • RPS5
  • ribonucleoprotein complex
  • cytosolic small ribosomal subunit
  • cytoplasm
  • small ribosomal subunit
  • 90S preribosome
  • ribosome
  • intracellular
  • translation
  • structural constituent of ribosome
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    cytosolic ribosome 5.9953E-24 20 101 15 6292
    cytosolic part 1.2211E-22 20 122 15 6292
    ribosomal subunit 6.9407E-20 20 183 15 6292
    cytosolic large ribosomal subunit 3.5509E-18 20 60 11 6292
    cytosol 5.7974E-17 20 284 15 6292
    ribosome 7.9586E-17 20 290 15 6292
    ribonucleoprotein complex 2.2689E-16 20 514 17 6292
    large ribosomal subunit 4.1338E-15 20 110 11 6292
    non-membrane-bounded organelle 3.6788E-9 20 959 15 6292
    intracellular non-membrane-bounded organelle 3.6788E-9 20 959 15 6292
    macromolecular complex 5.2143E-8 20 1635 17 6292
    cytosolic small ribosomal subunit 5.1144E-6 20 38 4 6292
    small ribosomal subunit 7.0211E-5 20 73 4 6292
    organelle part 4.7568E-4 20 2282 15 6292
    intracellular organelle part 4.7568E-4 20 2282 15 6292
    90S preribosome 1.2688E-3 20 17 2 6292
    cytoplasmic part 1.3405E-3 20 2482 15 6292
    stress granule 3.1786E-3 20 1 1 6292
    preribosome 5.067E-3 20 34 2 6292
    cytoplasm 6.983E-3 20 3552 17 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    translation 2.0785E-25 20 376 20 6292
    cellular protein metabolic process 3.8031E-16 20 1074 20 6292
    protein metabolic process 1.18E-15 20 1136 20 6292
    cellular macromolecule biosynthetic process 2.8607E-15 20 1187 20 6292
    macromolecule biosynthetic process 2.9594E-15 20 1189 20 6292
    gene expression 1.3717E-14 20 1283 20 6292
    cellular biosynthetic process 7.6887E-13 20 1567 20 6292
    biosynthetic process 1.1992E-12 20 1602 20 6292
    cellular macromolecule metabolic process 1.5096E-9 20 2285 20 6292
    macromolecule metabolic process 2.629E-9 20 2349 20 6292
    primary metabolic process 1.757E-7 20 2896 20 6292
    cellular metabolic process 4.4416E-7 20 3033 20 6292
    ribosomal subunit assembly 5.9497E-7 20 55 5 6292
    regulation of translation 7.1326E-7 20 57 5 6292
    metabolic process 9.9232E-7 20 3157 20 6292
    posttranscriptional regulation of gene expression 1.0054E-6 20 61 5 6292
    ribosome assembly 1.2808E-6 20 64 5 6292
    regulation of cellular protein metabolic process 1.7371E-6 20 68 5 6292
    organelle assembly 1.8691E-6 20 69 5 6292
    regulation of protein metabolic process 2.6524E-6 20 74 5 6292
    ribonucleoprotein complex assembly 7.8106E-6 20 92 5 6292
    ribosome biogenesis 5.9501E-5 20 346 7 6292
    ribosomal small subunit biogenesis 6.8171E-5 20 26 3 6292
    ribonucleoprotein complex biogenesis 9.7764E-5 20 374 7 6292
    cellular macromolecular complex assembly 2.0867E-4 20 182 5 6292
    ribosomal large subunit assembly 2.7112E-4 20 41 3 6292
    ribosomal small subunit assembly 8.5383E-4 20 14 2 6292
    cellular process 8.6878E-4 20 4426 20 6292
    ribosomal large subunit biogenesis 1.0582E-3 20 65 3 6292
    cellular macromolecular complex subunit organization 1.0596E-3 20 259 5 6292
    macromolecular complex assembly 1.5279E-3 20 281 5 6292
    negative regulation of mRNA processing 3.1786E-3 20 1 1 6292
    negative regulation of nuclear mRNA splicing, via spliceosome 3.1786E-3 20 1 1 6292
    negative regulation of RNA splicing 3.1786E-3 20 1 1 6292
    cellular component biogenesis 4.1117E-3 20 694 7 6292
    macromolecular complex subunit organization 4.3653E-3 20 357 5 6292
    cellular component assembly 6.0258E-3 20 385 5 6292
    regulation of mRNA processing 6.3477E-3 20 2 1 6292
    regulation of RNA splicing 6.3477E-3 20 2 1 6292
    regulation of nuclear mRNA splicing, via spliceosome 6.3477E-3 20 2 1 6292
    rRNA processing 7.2786E-3 20 128 3 6292
    rRNA metabolic process 8.7769E-3 20 137 3 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    structural constituent of ribosome 1.4532E-30 20 212 20 6292
    structural molecule activity 2.4725E-26 20 339 20 6292
    RNA binding 7.2769E-4 20 367 6 6292

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle