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View Protein Complex Details

Complex Overview

From Publication: Riffle <i>et al</i>. (2010) (Unpublished Data)
Notes: Complex predicted from the combined set of Gavin (2002), Gavin (2006), Ho (2002) and Krogan (2006); at p-value cutoff of 1E-7
Complex Size: 26 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
PUF4
  • cytoplasm
  • loss of chromatin silencing involved in replicative cell aging
  • protein localization
  • mRNA catabolic process
  • nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
  • mRNA binding
  • RPL11B
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • ribosomal large subunit assembly
  • translation
  • structural constituent of ribosome
  • RPL17A
  • cytoplasm
  • translation
  • structural constituent of ribosome
  • RPL17B
  • ribonucleoprotein complex
  • cytoplasm
  • large ribosomal subunit
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • translation
  • structural constituent of ribosome
  • RPL1A, RPL1B
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • regulation of translation
  • RNA processing
  • translation
  • RNA binding
  • structural constituent of ribosome
  • RPL20A
  • translation
  • structural constituent of ribosome
  • RPL21A
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • translation
  • structural constituent of ribosome
  • RPL24A
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • translation
  • RNA binding
  • structural constituent of ribosome
  • RPL2A, RPL2B
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • regulation of translation
  • response to drug
  • translation
  • RNA binding
  • structural constituent of ribosome
  • rRNA binding
  • RPL3
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • ribosomal large subunit assembly
  • translation
  • structural constituent of ribosome
  • RPL30
  • cytoplasm
  • negative regulation of nuclear mRNA splicing, via spliceosome
  • rRNA processing
  • negative regulation of translation
  • translation
  • structural constituent of ribosome
  • RPL32
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • translation
  • structural constituent of ribosome
  • RPL36A
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • translation
  • RNA binding
  • structural constituent of ribosome
  • RPL42B, RPL42A
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • response to antibiotic
  • response to cycloheximide
  • translation
  • structural constituent of ribosome
  • RPL4A
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • translation
  • structural constituent of ribosome
  • RPL6A
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic large ribosomal subunit
  • ribosome
  • intracellular
  • ribosomal large subunit assembly
  • translation
  • RNA binding
  • structural constituent of ribosome
  • RPS14A
  • small nucleolar ribonucleoprotein complex
  • maturation of SSU-rRNA
  • telomere maintenance
  • ribosomal small subunit assembly
  • translation
  • RNA binding
  • structural constituent of ribosome
  • RPS16B, RPS16A
  • ribonucleoprotein complex
  • cytosolic small ribosomal subunit
  • cytoplasm
  • ribosome
  • 90S preribosome
  • intracellular
  • regulation of translation
  • maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
  • ribosomal small subunit biogenesis
  • translation
  • structural constituent of ribosome
  • RPS17B
  • ribonucleoprotein complex
  • cytosolic small ribosomal subunit
  • cytoplasm
  • ribosome
  • intracellular
  • telomere maintenance
  • ribosomal small subunit assembly
  • translation
  • structural constituent of ribosome
  • RPS1A
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic small ribosomal subunit
  • ribosome
  • 90S preribosome
  • intracellular
  • translation
  • structural constituent of ribosome
  • RPS2
  • small nucleolar ribonucleoprotein complex
  • regulation of translational fidelity
  • translation
  • structural constituent of ribosome
  • RPS23B, RPS23A
  • ribonucleoprotein complex
  • cytosolic small ribosomal subunit
  • cytoplasm
  • small ribosomal subunit
  • ribosome
  • intracellular
  • maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
  • regulation of translational fidelity
  • translation
  • structural constituent of ribosome
  • RPS30B, RPS30A
  • stress granule
  • ribonucleoprotein complex
  • cytoplasm
  • cytosolic small ribosomal subunit
  • ribosome
  • intracellular
  • translation
  • structural constituent of ribosome
  • RPS5
  • ribonucleoprotein complex
  • cytosolic small ribosomal subunit
  • cytoplasm
  • small ribosomal subunit
  • 90S preribosome
  • ribosome
  • intracellular
  • translation
  • structural constituent of ribosome
  • RPS8B, RPS8A
  • ribonucleoprotein complex
  • cytosolic small ribosomal subunit
  • cytoplasm
  • 90S preribosome
  • ribosome
  • intracellular
  • regulation of translation
  • maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
  • translation
  • structural constituent of ribosome
  • RPS9B
  • small nucleolar ribonucleoprotein complex
  • regulation of translational fidelity
  • translation
  • structural constituent of ribosome
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    cytosolic ribosome 8.1699E-30 26 101 19 6292
    cytosolic part 4.0169E-28 26 122 19 6292
    ribosomal subunit 1.3893E-24 26 183 19 6292
    cytosol 7.4829E-21 26 284 19 6292
    ribonucleoprotein complex 8.4128E-21 26 514 22 6292
    ribosome 1.1204E-20 26 290 19 6292
    cytosolic large ribosomal subunit 1.5387E-18 26 60 12 6292
    large ribosomal subunit 3.4855E-15 26 110 12 6292
    non-membrane-bounded organelle 5.7956E-11 26 959 19 6292
    intracellular non-membrane-bounded organelle 5.7956E-11 26 959 19 6292
    cytosolic small ribosomal subunit 9.904E-11 26 38 7 6292
    macromolecular complex 5.7908E-10 26 1635 22 6292
    small ribosomal subunit 1.1649E-8 26 73 7 6292
    90S preribosome 5.2585E-7 26 17 4 6292
    preribosome 9.7696E-6 26 34 4 6292
    organelle part 1.4406E-4 26 2282 19 6292
    intracellular organelle part 1.4406E-4 26 2282 19 6292
    cytoplasmic part 5.1644E-4 26 2482 19 6292
    cytoplasm 2.3047E-3 26 3552 22 6292
    small nucleolar ribonucleoprotein complex 3.0929E-3 26 72 3 6292
    stress granule 4.1322E-3 26 1 1 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    translation 2.9333E-30 26 376 25 6292
    cellular macromolecule biosynthetic process 1.1746E-19 26 1187 26 6292
    macromolecule biosynthetic process 1.2278E-19 26 1189 26 6292
    gene expression 9.0594E-19 26 1283 26 6292
    cellular protein metabolic process 1.1032E-18 26 1074 25 6292
    protein metabolic process 4.5057E-18 26 1136 25 6292
    cellular biosynthetic process 1.7186E-16 26 1567 26 6292
    biosynthetic process 3.0662E-16 26 1602 26 6292
    cellular macromolecule metabolic process 3.3342E-12 26 2285 26 6292
    macromolecule metabolic process 6.8645E-12 26 2349 26 6292
    regulation of translation 3.7551E-11 26 57 8 6292
    posttranscriptional regulation of gene expression 6.6239E-11 26 61 8 6292
    regulation of cellular protein metabolic process 1.6331E-10 26 68 8 6292
    regulation of protein metabolic process 3.2788E-10 26 74 8 6292
    primary metabolic process 1.6287E-9 26 2896 26 6292
    cellular metabolic process 5.4447E-9 26 3033 26 6292
    metabolic process 1.5498E-8 26 3157 26 6292
    ribosomal subunit assembly 2.4257E-6 26 55 5 6292
    regulation of translational fidelity 5.1771E-6 26 9 3 6292
    ribosome assembly 5.1844E-6 26 64 5 6292
    ribosome biogenesis 5.6257E-6 26 346 9 6292
    organelle assembly 7.5356E-6 26 69 5 6292
    ribonucleoprotein complex biogenesis 1.0638E-5 26 374 9 6292
    maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) 1.7434E-5 26 13 3 6292
    regulation of translational elongation 1.7434E-5 26 13 3 6292
    ribonucleoprotein complex assembly 3.0919E-5 26 92 5 6292
    regulation of gene expression 4.3068E-5 26 445 9 6292
    regulation of macromolecule biosynthetic process 5.2261E-5 26 456 9 6292
    regulation of cellular biosynthetic process 6.8591E-5 26 472 9 6292
    regulation of biosynthetic process 6.9741E-5 26 473 9 6292
    regulation of macromolecule metabolic process 8.9073E-5 26 488 9 6292
    maturation of SSU-rRNA 8.9386E-5 26 59 4 6292
    cellular process 1.043E-4 26 4426 26 6292
    regulation of primary metabolic process 1.3338E-4 26 514 9 6292
    rRNA processing 1.5037E-4 26 128 5 6292
    ribosomal small subunit biogenesis 1.5294E-4 26 26 3 6292
    regulation of cellular metabolic process 1.8424E-4 26 536 9 6292
    rRNA metabolic process 2.0703E-4 26 137 5 6292
    translational elongation 2.1318E-4 26 29 3 6292
    regulation of metabolic process 2.1527E-4 26 547 9 6292
    ribosomal large subunit assembly 6.0179E-4 26 41 3 6292
    cellular macromolecular complex assembly 7.6891E-4 26 182 5 6292
    cellular component biogenesis 1.2649E-3 26 694 9 6292
    ribosomal small subunit assembly 1.4494E-3 26 14 2 6292
    ncRNA processing 1.6259E-3 26 215 5 6292
    ribosomal large subunit biogenesis 2.309E-3 26 65 3 6292
    regulation of cellular process 3.3355E-3 26 796 9 6292
    ncRNA metabolic process 3.5523E-3 26 257 5 6292
    cellular macromolecular complex subunit organization 3.673E-3 26 259 5 6292
    RNA processing 3.8191E-3 26 380 6 6292
    response to cycloalkane 4.1322E-3 26 1 1 6292
    response to organic cyclic substance 4.1322E-3 26 1 1 6292
    negative regulation of mRNA processing 4.1322E-3 26 1 1 6292
    negative regulation of nuclear mRNA splicing, via spliceosome 4.1322E-3 26 1 1 6292
    negative regulation of RNA splicing 4.1322E-3 26 1 1 6292
    response to cycloheximide 4.1322E-3 26 1 1 6292
    regulation of biological process 4.2304E-3 26 824 9 6292
    macromolecular complex assembly 5.205E-3 26 281 5 6292
    biological regulation 5.8373E-3 26 1213 11 6292
    regulation of mRNA processing 8.248E-3 26 2 1 6292
    regulation of RNA splicing 8.248E-3 26 2 1 6292
    regulation of nuclear mRNA splicing, via spliceosome 8.248E-3 26 2 1 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    structural constituent of ribosome 9.3763E-37 26 212 25 6292
    structural molecule activity 2.0211E-31 26 339 25 6292
    RNA binding 5.424E-4 26 367 7 6292

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle