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View Protein Complex Details

Complex Overview

From Publication: Riffle <i>et al</i>. (2010) (Unpublished Data)
Notes: Complex predicted from the combined set of Gavin (2002), Gavin (2006), Ho (2002) and Krogan (2006); at p-value cutoff of 1E-7
Complex Size: 11 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
BRR2
  • U4/U6 x U5 tri-snRNP complex
  • U5 snRNP
  • RNA splicing
  • mRNA metabolic process
  • auxin biosynthetic process
  • mRNA processing
  • spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
  • ATP-dependent RNA helicase activity
  • PRP11
  • U2 snRNP
  • spliceosome assembly
  • RNA binding
  • PRP8
  • U4/U6 x U5 tri-snRNP complex
  • U5 snRNP
  • nuclear mRNA 3'-splice site recognition
  • nuclear mRNA splicing, via spliceosome
  • U5 snRNA binding
  • RSE1
  • U2 snRNP
  • spliceosome assembly
  • nuclear mRNA splicing, via spliceosome
  • U2 snRNA binding
  • SMB1
  • U4/U6 x U5 tri-snRNP complex
  • U5 snRNP
  • U1 snRNP
  • nuclear mRNA splicing, via spliceosome
  • RNA binding
  • molecular_function
  • SMD1
  • commitment complex
  • U4/U6 x U5 tri-snRNP complex
  • U5 snRNP
  • U1 snRNP
  • nuclear mRNA splicing, via spliceosome
  • mRNA binding
  • SMD2
  • U4/U6 x U5 tri-snRNP complex
  • U5 snRNP
  • U1 snRNP
  • nuclear mRNA splicing, via spliceosome
  • RNA binding
  • molecular_function
  • SMD3
  • commitment complex
  • U4/U6 x U5 tri-snRNP complex
  • U5 snRNP
  • U1 snRNP
  • nuclear mRNA splicing, via spliceosome
  • mRNA binding
  • SNP1
  • commitment complex
  • U1 snRNP
  • nuclear mRNA splicing, via spliceosome
  • U1 snRNA binding
  • mRNA binding
  • SNU114
  • U4/U6 x U5 tri-snRNP complex
  • U5 snRNP
  • generation of catalytic spliceosome for first transesterification step
  • nuclear mRNA splicing, via spliceosome
  • GTP binding
  • U5 snRNA binding
  • GTPase activity
  • STO1
  • commitment complex
  • nuclear cap binding complex
  • nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
  • telomere maintenance
  • nuclear mRNA splicing, via spliceosome
  • mRNA binding
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    small nuclear ribonucleoprotein complex 5.243E-20 11 63 10 6292
    U5 snRNP 1.4613E-17 11 14 7 6292
    U4/U6 x U5 tri-snRNP complex 1.4188E-14 11 32 7 6292
    ribonucleoprotein complex 9.7932E-13 11 514 11 6292
    U1 snRNP 3.4512E-11 11 17 5 6292
    commitment complex 2.486E-9 11 12 4 6292
    U2-type spliceosomal complex 2.486E-9 11 12 4 6292
    nuclear part 4.6103E-9 11 1103 11 6292
    macromolecular complex 3.5578E-7 11 1635 11 6292
    spliceosomal complex 7.2654E-7 11 45 4 6292
    nucleus 4.1084E-6 11 2041 11 6292
    organelle part 1.4064E-5 11 2282 11 6292
    intracellular organelle part 1.4064E-5 11 2282 11 6292
    U2 snRNP 2.145E-4 11 13 2 6292
    membrane-bounded organelle 3.5629E-3 11 3771 11 6292
    intracellular membrane-bounded organelle 3.5629E-3 11 3771 11 6292
    nuclear cap binding complex 5.2364E-3 11 3 1 6292
    intracellular organelle 8.2563E-3 11 4070 11 6292
    organelle 8.2787E-3 11 4071 11 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    nuclear mRNA splicing, via spliceosome 8.2951E-21 11 99 11 6292
    RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 9.3204E-21 11 100 11 6292
    RNA splicing, via transesterification reactions 2.039E-20 11 107 11 6292
    RNA splicing 2.2776E-19 11 132 11 6292
    mRNA processing 1.5305E-18 11 156 11 6292
    mRNA metabolic process 5.1912E-17 11 213 11 6292
    RNA processing 3.3986E-14 11 380 11 6292
    RNA metabolic process 9.2688E-10 11 954 11 6292
    gene expression 2.4488E-8 11 1283 11 6292
    nucleic acid metabolic process 7.2197E-8 11 1415 11 6292
    nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 2.2108E-7 11 1566 11 6292
    ribonucleoprotein complex assembly 2.583E-7 11 92 5 6292
    cellular nitrogen compound metabolic process 8.537E-7 11 1770 11 6292
    nitrogen compound metabolic process 9.7232E-7 11 1791 11 6292
    spliceosome assembly 3.1985E-6 11 18 3 6292
    cellular macromolecular complex assembly 7.6897E-6 11 182 5 6292
    cellular macromolecule metabolic process 1.4269E-5 11 2285 11 6292
    macromolecule metabolic process 1.9349E-5 11 2349 11 6292
    cellular macromolecular complex subunit organization 4.2853E-5 11 259 5 6292
    macromolecular complex assembly 6.3461E-5 11 281 5 6292
    spliceosomal conformational changes to generate catalytic conformation 9.9377E-5 11 9 2 6292
    primary metabolic process 1.9438E-4 11 2896 11 6292
    macromolecular complex subunit organization 1.988E-4 11 357 5 6292
    ribonucleoprotein complex biogenesis 2.4767E-4 11 374 5 6292
    cellular component assembly 2.8391E-4 11 385 5 6292
    cellular metabolic process 3.2347E-4 11 3033 11 6292
    metabolic process 5.03E-4 11 3157 11 6292
    regulation of hormone levels 1.7483E-3 11 1 1 6292
    spliceosome conformational change to release U4 (or U4atac) and U1 (or U11) 1.7483E-3 11 1 1 6292
    auxin biosynthetic process 1.7483E-3 11 1 1 6292
    auxin metabolic process 1.7483E-3 11 1 1 6292
    hormone metabolic process 1.7483E-3 11 1 1 6292
    hormone biosynthetic process 1.7483E-3 11 1 1 6292
    nuclear mRNA 3'-splice site recognition 3.4937E-3 11 2 1 6292
    cellular component biogenesis 4.2093E-3 11 694 5 6292
    generation of catalytic spliceosome for first transesterification step 5.2364E-3 11 3 1 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    RNA binding 4.2317E-12 11 367 10 6292
    snRNA binding 2.5268E-11 11 5 4 6292
    nucleic acid binding 1.6541E-9 11 666 10 6292
    mRNA binding 2.5762E-7 11 35 4 6292
    binding 1.1791E-6 11 1294 10 6292
    U5 snRNA binding 2.779E-6 11 2 2 6292
    U2 snRNA binding 1.7483E-3 11 1 1 6292
    U1 snRNA binding 1.7483E-3 11 1 1 6292

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle