Protein Overview: YLR224W

General Information:
Name(s) found:	YLR224W [SGD]
Description(s) found: Found 22 descriptions. SHOW ALL	F-box protein and component of SCF ubiquitin ligase complexes involved in ubiquitin-dependent protein catabolism; readily monoubiquitinated in vitro by SCF-Ubc4 complexes; YLR224W is not an essential gene [SGD]
Organism:	Saccharomyces cerevisiae
Length:	369 amino acids
Gene Ontology:
Cellular Component:	ubiquitin ligase complex [IPI][ISS]
Biological Process:	ubiquitin-dependent protein catabolic process [IPI]
Molecular Function:	protein binding [IPI][ISS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNQSDSSLMD LPLEIHLSLL EYVPNELRAV NKYFYVLHNH SYKEKSLAWI AEDNYIWAVV  60
   61 KHSLCLYVKS LDPLRQHARE IIQETKEPGF NVPLCMTKYI ADSWYIVYNA LQYPGKIINM 120
  121 GWDKYTKSQD SNGSDSTSNF NSRPKERTLM QSLTALPVNF WSRRKDEPTP VNVWFYVKNA 180
  181 HVARYIPKII TEIGICNYGP KQIVASAGYI NELITSEGIY CVNLGHLPRL YDEQIFEGTG 240
  241 TTHLPLELKA IDRTDSDVCI NGDLVLLGYD FIPYQISKPW LLFRIEPVNS IEAIFNYSEC 300
  301 SFSYQFAWSL ACLQSEEKIS FPRDTIIGHG LPYKPSKLIR IFVYKHPEQK QDLGQEIALP 360
  361 NWNTPYLRR

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Qiu et al. (2008)		MET30 YLR224W YNL311C

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	SKP1	YLR224W	2	Uetz P, et al. (2000)
View Screen	SKP1	YLR224W	2	Unpublished Fields Lab Data
View Screen	YLR224W	YBR284W	2	Unpublished Fields Lab Data
View Screen	YLR224W	RUB1	2	Unpublished Fields Lab Data

Microscopy / Localization Data

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No microscopy data found in the PDR for this protein.

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..369]	deduced	N/A	No confident structure predictions are available.

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Source: Reynolds et al. (2008)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2