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Protein Overview: GNAI2_RAT

General Information:
Name(s) found: GNAI2_RAT [Swiss-Prot]
Description(s) found:
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  • pir||RGRTI2 GTP-binding regulatory protein Gi alpha-2 chain (adenylate cyclase-inhibiting) - rat [NCBI NR]
  • gi|71089913|gb|AAZ23811.1| guanine nucleotide binding protein alpha inhibiting 2 [Rattus norvegicus] [NCBI NR]
  • gi|71089911|gb|AAZ23810.1| guanine nucleotide binding protein alpha inhibiting 2 [Rattus norvegicus] [NCBI NR]
  • gi|50926804|gb|AAH78806.1| Guanine nucleotide binding protein (G protein), alpha inhibiting 2 [Rattus norvegicus] [NCBI NR]
  • gi|204440|gb|AAA41260.1| Guanine nucleotide-binding protein alpha subunit [NCBI NR]
  • gi|203166|gb|AAA40824.1| GTP-binding protein [NCBI NR]
  • gi|149018581|gb|EDL77222.1| rCG26094, isoform CRA_c [Rattus norvegicus] [NCBI NR]
  • gi|13591955|ref|NP_112297.1| guanine nucleotide binding protein, alpha inhibiting 2 [Rattus norvegicus] [NCBI NR]
  • gi|121025|sp|P04897.3|GNAI2_RAT RecName: Full=Guanine nucleotide-binding protein G(i), alpha-2 subunit; AltName: Full=Adenylate cyclase-inhibiting G alpha protein [NCBI NR]
  • Guanine nucleotide-binding protein G(i) subunit alpha-2 OS=Rattus norvegicus GN=Gnai2 PE=1 SV=3 [Swiss-Prot]
  • GTP-binding protein (G-alpha-i2) [HMR_022704-rand.fasta]
  • GTP-binding protein (G-alpha-i2) [Rattus norvegicus]gi|50926804|gb|AAH78806.1| GTP-binding protein (G-alpha-i2) [Rattus norvegicus]gi|71896|pir||RGRTI2 GTP-binding regulatory protein Gi alpha-2 chain (adenylate cyclase-inhibiting) - ratgi|121025|sp|P04 [nrdb_11152004_Chlamydomonas]
  • Tax_Id=10116 Guanine nucleotide binding protein alpha inhibiting 2 [EBI-IPI_rat_3.13_12-01-2005_con_reversed.fasta]
  • (NM_031035) GTP-binding protein (G-alpha-i2) [Rattus norvegicus] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta]
  • Guanine nucleotide-binding protein G(i), alpha-2 subunit (Adenylate cyclase-inhibiting G alpha protein) [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • Guanine nucleotide binding protein (G protein), alpha inhibiting 2 [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • guanine nucleotide binding protein, alpha inhibiting 2 [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • rCG26094, isoform CRA_c [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • guanine nucleotide binding protein alpha inhibiting 2 [Rattus norvegicus] [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • Guanine nucleotide-binding protein alpha subunit [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • GTP-binding protein [NCBI-RefSeq_multi-organisms_na_08-12-2008_con_reversed.fasta]
  • Tax_Id=10116 GTP-BINDING PROTEIN (G-ALPHA-I2) [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta]
  • Guanine nucleotide binding protein, alpha inhibiting 2 [Rattus norvegicus] [nr-271106-contam.fasta]
  • Tax_Id=10116 Gene_Symbol=Gnai2 Guanine nucleotide-binding protein G(i), alpha-2 subunit [rat-ipi-250309-contam.fasta]
  • Guanine nucleotide-binding protein G(i) subunit alpha-2 OS=Rattus norvegicus GN=Gnai2 [011711_HMR.fasta]
  • Guanine nucleotide binding protein alpha inhibiting 2 OS=Rattus norvegicus GN=Gnai2 [011711_HMR.fasta]
  • Guanine nucleotide binding protein alpha inhibiting 2 OS=Rattus norvegicus GN=Gnai2 PE=2 SV=1 [UNIPROT_RAT_07-21-2011_reversed.fasta]
  • Isoform of P04897, Guanine nucleotide binding protein alpha inhibiting 2 OS=Rattus norvegicus GN=Gnai2 PE=1 SV=1 [RAT.fasta.20160308]
    • Organism: Rattus norvegicus
    Length: 355 amino acids

    Gene Ontology:
    Cellular Component: membrane fraction [IDA]
    nucleus [IDA]
    membrane raft [IDA]
    cytosol [IDA]
    plasma membrane [UNKNOWN][IDA]
    Biological Process: inhibition of adenylate cyclase activity by G-protein signaling pathway [UNKNOWN][IEA]
    cell proliferation [UNKNOWN]
    G-protein coupled receptor protein signaling pathway [IDA]
    signal transduction [IEA]
    negative regulation of synaptic transmission [IDA]
    negative regulation of calcium ion transport via voltage-gated calcium channel activity [IDA]
    positive regulation of cell proliferation [IMP]
    [NOT]regulation of heart contraction [UNKNOWN]
    muscarinic acetylcholine receptor signaling pathway [UNKNOWN][IEA]
    intracellular protein kinase cascade [IMP]
    [NOT]metabotropic glutamate receptor signaling pathway [IDA]
    gamma-aminobutyric acid signaling pathway [IDA]
    activation of MAPKK activity [IMP]
    adenosine receptor signaling pathway [IDA]
    Molecular Function: nucleotide binding [IEA]
    GTP binding [UNKNOWN][IEA]
    protein binding [UNKNOWN][IEA]
    guanyl nucleotide binding [IEA]
    signal transducer activity [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGCTVSAEDK AAAERSKMID KNLREDGEKA AREVKLLLLG AGESGKSTIV KQMKIIHEDG  60
   61 YSEEECRQYR AVVYSNTIQS IMAIVKAMGN LQIDFADPQR ADDARQLFAL SCAAEEQGML 120
  121 PEDLSGVIRR LWADHGVQAC FGRSREYQLN DSAAYYLNDL ERIAQSDYIP TQQDVLRTRV 180
  181 KTTGIVETHF TFKDLHFKMF DVGGQRSERK KWIHCFEGVT AIIFCVALSA YDLVLAEDEE 240
  241 MNRMHESMKL FDSICNNKWF TDTSIILFLN KKDLFEEKIT QSPLTICFPE YTGANKYDEA 300
  301 ASYIQSKFED LNKRKDTKEI YTHFTCATDT KNVQFVFDAV TDVIIKNNLK DCGLF

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data



    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.66

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle