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Protein Overview: CENPE_MOUSE

General Information:
Name(s) found: CENPE_MOUSE [Swiss-Prot]
Description(s) found:
Found 17 descriptions.
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  • Centromere-associated protein E OS=Mus musculus GN=Cenpe PE=1 SV=1 [Swiss-Prot]
    • Organism: Mus musculus
    Length: 2474 amino acids

    Gene Ontology:
    Cellular Component: cytoskeleton [IEA]
    cytoplasm [IEA]
    kinetochore [IDA]
    chromosome, centromeric region [UNKNOWN]
    Biological Process: mitotic cell cycle spindle assembly checkpoint [IMP]
    regulation of mitosis [IMP]
    multicellular organismal development [IEA]
    positive regulation of mitotic metaphase/anaphase transition [IMP]
    mitosis [IEA]
    microtubule-based movement [IEA]
    cell cycle [IEA]
    cell division [IEA]
    establishment of protein localization [IMP]
    positive regulation of chromosome segregation [IMP]
    regulation of developmental process [IMP]
    positive regulation of protein kinase activity [IDA]
    attachment of spindle microtubules to kinetochore [IMP][TAS]
    positive regulation of attachment of spindle microtubules to kinetochore [IMP]
    Molecular Function: nucleotide binding [IEA]
    kinetochore binding [IDA]
    ATP binding [IEA]
    protein kinase binding [IPI]
    microtubule motor activity [IEA]
    motor activity [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAEEASVAVC VRVRPLNSRE EELGEATHIY WKTDKNAIYQ SDGGKSFQFD RVFDSNETTK  60
   61 NVYEEIAVPI ISSAIQGYNG TIFAYGQTAS GKTHTMMGSE DCLGVIPRAI HDIFQRIKKF 120
  121 PEREFLLRVS YMEIYNETIT DLLCNAQKMK PLIIREDTNR TVYVSDLTEE VVYTAEMALK 180
  181 WLATGEKNRH YGITKMNQRS SRSHTIFRMI LESREKAEPS NCDGSVKVSH LNLVDLAGSE 240
  241 RAAQTGAEGV RLKEGCFINR NLFILGQVIK KLSDGQVGGF INYRDSKLTR ILQNSLGGNA 300
  301 KTRIICTITP ASLDETLTTL QFASTAKYMK NTPYVNEVSN DEALLKRYRR EIADLRKQLE 360
  361 EVNTKTRAQE MEKDQLAQLL DEKDLLQKVQ DEKINNLKRM LVTSSSIALQ QELEIKRKRR 420
  421 VTWCYGKMKD SNYEKEFKVP TSITTRKRKT SVTSLRENSL MKFGESAASS EFEMLNNTLE 480
  481 SLAEVEWSSA TTLLSEENVE SELNSLNAQY NDLVLDYEQL RRENEDLKLK LKEKNELEEF 540
  541 ELLEQKEERD QEMQLMHEVS NLKNLIKHAE EYNQDLENDL SSKVKLLKEK EEQIKNLQEY 600
  601 IDAQKSEKMK IDLSYTSDAT EDLKQAMRTL SDLDTVALDA KKESAFLRSE NLELKEKINE 660
  661 LSDSRKQMES DIQMYQRQLE AKKKMQTDLD KELQLAFQEI SKLSALVDGK GLLSNLELEK 720
  721 RITDLQKELN KEAEEKQTLQ EEVNLLSELK SLPSEVETLR RELYEKSEEL HIITTEREKL 780
  781 FSEMAHKDSR IQGLLEEIGN TRDDLATSQL SRRGSDGEWQ ALESLHAELE HRHAGVLEER 840
  841 ERLKQEIGAL SKEAESLAFS LDSVKAELSH KTQELEQKTV EGQERLNKME ALREELESRD 900
  901 SSLQSVEKEK VLLTEKLQQA LKEVKALTQE KKNLKQLQES LQTERDQLRS DIQDTVNMNI 960
  961 DTQEQLLNAL ESLKQHQETI NMLKMKAAEE LSDNLHVKDR GGARDEAQQK MDGIDEQNES1020
 1021 AHTLLGGGKD NEVTEEQRKI DSLMQENSGL QQTLESVRAE KEQLKMDLKE NIEMSIENQE1080
 1081 ELRILRDELK RQQEVAAQEK DHATEKTQEL SRTQERLAKT EEKLEEKNQK LQETQQQLLS1140
 1141 TQEAMSKLQA KVIDMESLQN EFRNQGLALE RVETEKLELA QRLHESYEEV KSITKERNDL1200
 1201 KELQESFEIE KKQLKEYARE IEAEGLQAKE ELNIAHANLK EYQEIITELR GSISENEAQG1260
 1261 ASTQDTAKSA PELQGEVPEL LEQELLPVVK EARHSAEKVN GLEPVGAHSR TVHSMTMEGI1320
 1321 EIGNLRLTKK LEESQMEISC LTREREDLRR TQETLQVECT QLKEDARRTL ANHLETEEEL1380
 1381 NLARCCLKEQ ENKIDTLITS LSQRETELSS VRGQLALTTA ELERKVQELC EKQEELTRKE1440
 1441 TSEAQGKMSE LEQLRELLLA QASALQNAES DRLRLNTQLE ESQEEMKTLR EEREELRRMQ1500
 1501 EALHVESEQQ KESMKEISSK LQELQNKEYE CLAMKTINET QGSRCEMDHL NQQLEAQKST1560
 1561 LEKVEMENVN LTQRLHETLE EMRSVAKERD ELWSMEERLT VERDQLKKSL EETVTKGMEK1620
 1621 EEELRVAHVH LEEHQETINK LRKMVSDYTD EISHTQGDLK HTNAVVEAQN QDLREKEHQL1680
 1681 SQVKADLRET VDQMEQLKKK LEAQSSTLES REIEKLELTQ QLNENLKKIT LVTKENDSLK1740
 1741 IMDEALREER DQLRKSLQQT EARDLENQEK LRIAHMNLKE HQETIDRLME TMSEKTEEIS1800
 1801 NMKMELENVN MKLQEKVQEL KTSERQRVKL KADASEAKKE LKEQGLTLSK IEMENLNLAQ1860
 1861 KIHENLEEMK SVRKERDDLK KLEEILRMER DQLKDNLREA MLKAHQNHEE TMKCGKGLLC1920
 1921 AGEYCTGRLR EKCFRIEKLL KRYSEMANDY ECLNKVSLDL ERETKTQKEL SVTVRTKLSL1980
 1981 PHTQTKEMEK LLTANQRCSL EFHRALKRLK YVLSSIARIK EEQHESINKR EMAFIQEVEK2040
 2041 QNELQIQIQS LSQTYRIPAR DLQIKLSQEM DLHIEEMLKD FSENDFLTIK TEVQQVLNNR2100
 2101 KEITEFLGKW LNTLFDTENL KSTIQKENKS IGLVNNFYHS RITAMINEST EFEERSATRS2160
 2161 KDLDQYLKSL KETTEQLSEV YQTLTASQSV VHLHPTVQPS TRDSERPQAA SGAEQLTSKN2220
 2221 KIALGAVPYK EEIEDLKMQL VKSDLEKKAT AKEFDKKILS LKATVEHQEE MIRLLRENLR2280
 2281 GHQQAQDTSM ISEQDSQLLS KPLTCGGGSG IVQSTKALIL KSEYKRMGSE ISKLKQQNEQ2340
 2341 LRKQNNQLLS DNSQLSNEVK TWEERTLKRD SYRETTCENS PKSPKVTRTD SKRRQNTTSQ2400
 2401 CRAQNLQDPV PKDSPKSWFF DNRSKSLPAP HPIRYFDNSS LGLCPEPDDV ENVEPKTDLC2460
 2461 QASLEKDVSQ CKTQ

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data



    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle