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Protein Overview: fdl-PB

General Information:
Name(s) found: fdl-PB / FBpp0087058 [FlyBase]
Description(s) found:
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  • gi|45551090|ref|NP_725178.2| fused lobes, isoform B [Drosophila melanogaster] [NCBI NR]
  • gi|45445574|gb|AAM68691.2| fused lobes, isoform B [Drosophila melanogaster] [NCBI NR]
  • The gene fused lobes is referred to in FlyBase by the symbol Dmel\fdl (CG8824, FBgn0045063). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:8375253..8394841. It has the cytological map location 49A9-49A10. There is experimental evidence that it has the molecular function</span>: beta-N-acetylglucosaminidase activity. There is experimental evidence that it is involved in the biological process</span>: brain development; N-glycan processing. 12 alleles are reported. The phenotypes of these alleles are annotated with: protocerebral bridge; mushroom body beta-lobe. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
  • (AAM68691) CG8824-PB [DrosMelano7227.FASTAC.txt]
  • CG8824-PB, isoform B [Drosophila melanogaster]gi|45551090|ref|NP_725178.2| CG8824-PB [Drosophila melanogaster] [nrdb_11152004_Chlamydomonas]
  • type=protein; loc=2R:complement(8375945..8376199,8376267..8376585,8376651..8377386,8377451..8377959,8378028..8378210,8378832..8378851); ID=FBpp0087058; name=fdl-PB; parent=FBgn0045063,FBtr0087947; dbxref=GB_protein:AAM68691.1,FlyBase:FBpp0087058,FlyBase_A [fly-100309-contam.fasta]
  • fused lobes CG8824-PB, isoform B [Drosophila melanogaster] [nr-271106-contam.fasta]
  • CG8824-PB, isoform B [Drosophila melanogaster] [nr-271106-contam.fasta]
  • type=protein; loc=2R:complement(8375945..8376199,8376267..8376585,8376651..8377386,8377451..8377959,8378028..8378210,8378832..8378851); ID=FBpp0087058; name=fdl-PB; parent=FBgn0045063,FBtr0087947; dbxref=GB_protein:AAM68691.1,FlyBase:FBpp0087058,FlyBase_Annotation_IDs:CG8824-PB,GB_protein:AAM68691.2,REFSEQ:NP_725178,GB_protein:AAM68691; MD5=ec86ebff3b1196f6d308d5eb76561618; length=673; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta]
  • type=protein; loc=2R:complement(8375945..8376199,8376267..8376585,8376651..8377386,8377451..8377959,8378028..8378210,8378832..8378851); ID=FBpp0087058; name=fdl-PB; parent=FBgn0045063,FBtr0087947; dbxref=GB_protein:AAM68691.1,FlyBase:FBpp0087058,FlyBase_Annotation_IDs:CG8824-PB,GB_protein:AAM68691.2,REFSEQ:NP_725178,GB_protein:AAM68691; MD5=ec86ebff3b1196f6d308d5eb76561618; length=673; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta]
  • Isoform B of Probable beta-hexosaminidase fdl OS=Drosophila melanogaster GN=fdl [UniProt_drosophila_07-01-2011_reversed.fasta]
  • type=protein; loc=2R:complement(8375945..8376199,8376267..8376585,8376651..8377386,8377451..8377959,8378028..8378210,8378832..8378851); ID=FBpp0087058; name=fdl-PB; parent=FBgn0045063,FBtr0087947; dbxref=GB_protein:AAM68691.1,FlyBase:FBpp0087058,FlyBase_Annotation_IDs:CG8824-PB,GB_protein:AAM68691.2,REFSEQ:NP_725178,GB_protein:AAM68691,FlyMine:FBpp0087058,modMine:FBpp0087058; MD5=ec86ebff3b1196f6d308d5eb76561618; length=673; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta]
  • type=protein; loc=2R:complement(join(12491327..12491346,12490523..12490705,12489946..12490454,12489146..12489881,12488762..12489080,12488440..12488694)); ID=FBpp0087058; name=fdl-PB; parent=FBgn0045063,FBtr0087947; dbxref=GB_protein:AAM68691.1,FlyBase:FBpp0087058,FlyBase_Annotation_IDs:CG8824-PB,GB_protein:AAM68691.2,REFSEQ:NP_725178,GB_protein:AAM68691,FlyMine:FBpp0087058,modMine:FBpp0087058; MD5=ec86ebff3b1196f6d308d5eb76561618; length=673; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta]
  • type=protein; loc=2R:complement(join(12491327..12491346,12490523..12490705,12489946..12490454,12489146..12489881,12488762..12489080,12488440..12488694)); ID=FBpp0087058; name=fdl-PB; parent=FBgn0045063,FBtr0087947; dbxref=GB_protein:AAM68691.1,FlyBase:FBpp0087058,FlyBase_Annotation_IDs:CG8824-PB,GB_protein:AAM68691.2,REFSEQ:NP_725178,GB_protein:AAM68691,FlyMine:FBpp0087058,modMine:FBpp0087058; MD5=ec86ebff3b1196f6d308d5eb76561618; length=673; release=r6.07; species=Dmel; [fly-08202015-contam.fasta]
  • Isoform of Q8WSF3, Isoform B of Probable beta-hexosaminidase fdl OS=Drosophila melanogaster GN=fdl [DROME.fasta.20160308]
  • FBpp0087058 type=protein; loc=2R:complement(join(12491327..12491346,12490523..12490705,12489946..12490454,12489146..12489881,12488762..12489080,12488440..12488694)); ID=FBpp0087058; name=fdl-PB; parent=FBgn0045063,FBtr0087947; dbxref=GB_protein:AAM68691.1,FlyBase:FBpp0087058,FlyBase_Annotation_IDs:CG8824-PB,GB_protein:AAM68691.2,REFSEQ:NP_725178,GB_protein:AAM68691,FlyMine:FBpp0087058,modMine:FBpp0087058; MD5=ec86ebff3b1196f6d308d5eb76561618; length=673; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta]
  • [fly-122215-dmel-6-09-contam.fasta]
  • type=protein; loc=2R:complement(join(12491327..12491346,12490523..12490705,12489946..12490454,12489146..12489881,12488762..12489080,12488440..12488694)); ID=FBpp0087058; name=fdl-PB; parent=FBgn0045063,FBtr0087947; dbxref=GB_protein:AAM68691.1,FlyBase:FBpp0087058,FlyBase_Annotation_IDs:CG8824-PB,GB_protein:AAM68691.2,REFSEQ:NP_725178,GB_protein:AAM68691,FlyMine:FBpp0087058,modMine:FBpp0087058; MD5=ec86ebff3b1196f6d308d5eb76561618; length=673; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
    • Organism: Drosophila melanogaster
    Length: 673 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRYVYESLRY LYKMSLAVSL RRALLVLLTG AIFILTVLYW NQGVTKAQAY NEALERPHSH  60
   61 HDASGFPIPV EKSWTYKCEN DRCMRVGHHG KSAKRVSFIS CSMTCGDVNI WPHPTQKFLL 120
  121 SSQTHSFSVE DVQLHVDTAH REVRKQLQLA FDWFLKDLRL IQRLDYVGSS SEPTVSESSS 180
  181 KSRHHADLEP AATLFGATFG VKKAGDLTSV QVKISVLKSG DLNFSLDNDE TYQLSTQTEG 240
  241 HRLQVEIIAN SYFGARHGLS TLQQLIWFDD EDHLLHTYAN SKVKDAPKFR YRGLMLDTSR 300
  301 HFFSVESIKR TIVGMGLAKM NRFHWHLTDA QSFPYISRYY PELAVHGAYS ESETYSEQDV 360
  361 REVAEFAKIY GVQVIPEIDA PAHAGNGWDW GPKRGMGELA MCINQQPWSF YCGEPPCGQL 420
  421 NPKNNYTYLI LQRIYEELLQ HTGPTDFFHL GGDEVNLDCW AQYFNDTDLR GLWCDFMLQA 480
  481 MARLKLANNG VAPKHVAVWS SALTNTKCLP NSQFTVQVWG GSTWQENYDL LDNGYNVIFS 540
  541 HVDAWYLDCG FGSWRATGDA ACAPYRTWQN VYKHRPWERM RLDKKRKKQV LGGEVCMWTE 600
  601 QVDENQLDNR LWPRTAALAE RLWTDPSDDH DMDIVPPDVF RRISLFRNRL VELGIRAEAL 660
  661 FPKYCAQNPG ECI

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..94] deduced N/A No confident structure predictions are available.
    2 View Details [95..673] PSI-BLAST 127.0 Human beta-Hexosaminidase B

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • hydrolase activity, hydrolyzing O-glycosyl compounds
    		•  6.26329339735894 bayes_pls_golite062009
  • hydrolase activity, acting on glycosyl bonds
    		•  5.92180849080637 bayes_pls_golite062009
  • chitinase activity
    		•  5.52705867024 bayes_pls_golite062009
  • galactosidase activity
    		•  5.29959220339307 bayes_pls_golite062009
  • hyalurononglucosaminidase activity
    		•  5.08011231554191 bayes_pls_golite062009
  • alpha-galactosidase activity
    		•  4.85819791163713 bayes_pls_golite062009
  • hexosaminidase activity
    		•  4.40461026870613 bayes_pls_golite062009
  • hydrolase activity
    		•  3.5336140444552 bayes_pls_golite062009
  • mannosidase activity
    		•  2.76650385192253 bayes_pls_golite062009
  • beta-N-acetylhexosaminidase activity
    		•  2.69072465526737 bayes_pls_golite062009
  • transferase activity, transferring hexosyl groups
    		•  2.06059323252952 bayes_pls_golite062009
  • glucosidase activity
    		•  1.92306554001182 bayes_pls_golite062009
  • catalytic activity
    		•  1.85569074294201 bayes_pls_golite062009
  • alpha-amylase activity
    		•  1.42264105957213 bayes_pls_golite062009
  • amylase activity
    		•  1.37652764526134 bayes_pls_golite062009
  • chitin binding
    		•  1.29046765706168 bayes_pls_golite062009
  • signal transducer activity
    		•  0.934517587656668 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.934517587656668 bayes_pls_golite062009
  • mannose binding
    		•  0.927066555435524 bayes_pls_golite062009
  • transporter activity
    		•  0.882190348056302 bayes_pls_golite062009
  • beta-mannosidase activity
    		•  0.858618539860091 bayes_pls_golite062009
  • binding
    		•  0.800444849784015 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  0.696239852087965 bayes_pls_golite062009
  • beta-glucuronidase activity
    		•  0.55376725638834 bayes_pls_golite062009
  • sugar binding
    		•  0.52048704356718 bayes_pls_golite062009
  • alpha-glucosidase activity
    		•  0.502835520523619 bayes_pls_golite062009
  • receptor binding
    		•  0.497417763506343 bayes_pls_golite062009
  • beta-N-acetylglucosaminidase activity
    		•  0.489832278458081 bayes_pls_golite062009
  • transferase activity, transferring glycosyl groups
    		•  0.23234868908353 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.223550370855368 bayes_pls_golite062009
  • carbohydrate binding
    		•  0.102788238231918 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  7.36798954279472E-5 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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