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Protein Overview: CG8850-PB

General Information:
Name(s) found: CG8850-PB / FBpp0087080 [FlyBase]
Description(s) found:
Found 17 descriptions.
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  • This gene is referred to in FlyBase by the symbol Dmel\CG8850 (CG8850, FBgn0033708). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:8186283..8189741. It has the cytological map location 48F6. Based on sequence similarity, it is predicted to have molecular function</span>: neurotransmitter transporter activity; potassium:amino acid symporter activity. Based on sequence similarity, it is predicted to be involved in the biological process</span>: neurotransmitter transport. 2 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 629 amino acids

    Gene Ontology:
    Cellular Component: integral to plasma membrane [IEA]
    Biological Process: neurotransmitter transport [ISS]
    Molecular Function: neurotransmitter transporter activity [ISS]
    neurotransmitter:sodium symporter activity [IEA]
    potassium:amino acid symporter activity [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDDDAEYQKL RRNMQGAQGS REGHPGSNDG ISTVIYSAEG EELTINCEAE SESSGQRDQW  60
   61 SRGVEFLFSC IALSVGLGNV WRFPFIALEN GGGAFLIPYV IVLLLIGRPV YYLEVIIGQF 120
  121 SSRGCIRAFD MAPIMRGIAY GQVYSTALAT TYYACIMALT IRYLVASFSE VLPWTYCLVE 180
  181 WGKSCVATGA TAANDSSIVQ GVSSAELFFT QTVLREPESL DDNGLGTPSW DLVLCLLATW 240
  241 VIIGTILSKG IRSSGKASYF LALFPYVIMI VLLIRAVTLP GAWQGIVYFL KPQWSQLLNP 300
  301 HVWYAAITQM FFSLAICFGT LVMYASFNDF NKNVHKDVII ITTIDSLTSI LAGCIIFGIL 360
  361 GNLAFETNTK DISQVVKGGA GLAFISYPEA IAKFKYLPQL FAVLFFFMLL VLGIGSNIGM 420
  421 ASAVVNVVKD RFTHLPHWLL AVSASIIGFL CGLVYMTPGG QFVLNLVDFY GCTFIALVLA 480
  481 IAELLAVGWI YGVKRICSDI EFMLNVKTSF YWRICWAIVA PGLMFLVLVY MLFSYEPLTY 540
  541 RGVQYPPVYY MAGWIIWGLG VLQLPFWALV TIYQQPGKTF GSKFGLAMQP TANWGPLQTQ 600
  601 KFEAYIIHRK READFKSPRG GYLFDNIFG

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..537] PSI-BLAST 54.0 Crystal structure of LEUTAA, a bacterial homolog of Na+/Cl--dependent neurotransmitter transporters
    2 View Details [538..629] deduced N/A No confident structure predictions are available.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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