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Protein Overview: Fs-PA

General Information:
Name(s) found: Fs-PA / FBpp0089409 [FlyBase]
Description(s) found:
Found 21 descriptions.
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  • The gene Follistatin is referred to in FlyBase by the symbol Dmel\Fs (CG33466, FBgn0259878). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:11111061..11129084. It has the cytological map location 51E7-51E10. Its molecular function is unknown. There is experimental evidence that it is involved in the biological process</span>: negative regulation of decapentaplegic receptor signaling pathway; positive regulation of activin receptor signaling pathway; negative regulation of activin receptor signaling pathway. 6 alleles are reported. The phenotypes of these alleles are annotated with: pupa; air bubble; ISNb; wing; larval optic lobe; anterior pupal spiracle. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 767 amino acids

    Gene Ontology:
    Cellular Component: extracellular region [IDA]
    Biological Process: negative regulation of activin receptor signaling pathway [IDA]
    positive regulation of activin receptor signaling pathway [IDA]
    negative regulation of decapentaplegic receptor signaling pathway [IDA]
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPHHHHQHQP TSSQNNLTFL KSNYKFKRRA MSMAIRALPA TTTPAEARRA EPSQNTDQLA  60
   61 ATMSKTSAAT ATQLARATSR ECRTILGLFI VSAWSALQEL ANCLRQDEDR YVGHGRDVNA 120
  121 SSDASDEVSM AREQQQHQRQ HSKHSASSSP AKSMRCTRAK AASASTGTAA ATATLGAAAA 180
  181 EGATSGHQLG GQPLMALLIG LLLLNFRLAA AGTCWQTHLG SGKCGQVFST DISRSECCGS 240
  241 SQSFSYTDRE LSSVEYFFAT AIGGGVECSP CMESCKGFKC GPNKKCVKRK GRPKCVCAPE 300
  301 CGAALRRRTH QQELELEQEP ELEEEQQEMK PPRESRSLSS ENTNFNLGLD GGQRQRADNQ 360
  361 RKLQPRESKH RRLLIIDSSS RSSSNLPDQP TSGRRGRVEM TGYERRRHRN NHGKHLTRSM 420
  421 TTGANDSFPA DKTPAQSPAA DSILAQSRLA NLANANEPAN DINRQSSTRV RHQHARRIEH 480
  481 APNPDNGLRK RQHKQQQQHQ HQHQDRMNTE AQSANTTVSG SGSGATNHRR ISQLQHGSET 540
  541 AASSDLANTH DLAHLGGIYA PLPPQHSNPV CGTDGRTYNT ECQLRKRACR TNNAQLEVAY 600
  601 RGHCKNSCSG VHCLNGLTCV EDQYLMPHCI ACRIECPWDN LDVDSSGYDE RQAVCGVDGK 660
  661 TYRSACDINR MICKIGRSIA VAYPGPCRAG RVSCADIKCG PKDNCLVDLQ TRQPRCVTCR 720
  721 YKCPRKQQRP VHKICGYNNQ TYNSWCEMHK HSCESRYFIG VKSQGSC

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..219] PSI-BLAST 11.69897 No description for 2p6aD was found.
    2 View Details [220..341] PSI-BLAST 5.39794 Hybrid domain of integrin beta; Integrin beta A domain; Integrin beta tail domain; Integrin beta EGF-like domains
    3 View Details [342..700] PSI-BLAST 8.69897 Low density lipoprotein (LDL) receptor YWTD domain; Low density lipoprotein (LDL) receptor, different EGF domains; Ligand-binding domain of low-density lipoprotein receptor
    4 View Details [701..767] FFAS03 2.02 No description for 2p6aD was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • binding
    		•  0.286076792172079 bayes_pls_golite062009
  • protein binding
    		•  0.14494900666454 bayes_pls_golite062009
    4 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.48

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle