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Protein Overview: Dg-PC

General Information:
Name(s) found: Dg-PC / FBpp0086396 [FlyBase]
Description(s) found:
Found 20 descriptions.
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  • The gene Dystroglycan is referred to in FlyBase by the symbol Dmel\Dg (CG18250, FBgn0034072). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:11968674..11986042. It has the cytological map location 52E2-52E4. There is experimental evidence that it has the molecular function</span>: protein binding. There is experimental evidence for 14 unique biological process</span> terms, many of which group under: anatomical structure development; cell morphogenesis; reproductive process in a multicellular organism; establishment or maintenance of cell polarity; organ morphogenesis; oocyte axis specification; organ development; synaptic transmission; muscle organ development; muscle homeostasis; establishment or maintenance of polarity of follicular epithelium; multicellular organism reproduction. 24 alleles are reported. The phenotypes of these alleles are annotated with: leg; posterior crossvein; eye; crossvein; follicle cell; wing. It has 3 annotated transcripts and 3 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 1179 amino acids

    Gene Ontology:
    Cellular Component: T-tubule [IDA]
    basal plasma membrane [IDA]
    dystrophin-associated glycoprotein complex [IPI]
    dystroglycan complex [IDA][ISS][NAS]
    Biological Process: establishment or maintenance of apical/basal cell polarity [IMP]
    muscle cell homeostasis [IMP]
    regulation of synaptic activity [IMP]
    establishment or maintenance of cell polarity [IMP]
    growth of a germarium-derived egg chamber [IMP]
    sarcomere organization [IMP]
    axon guidance [IGI]
    imaginal disc-derived wing vein specification [IMP]
    cytoskeletal anchoring at plasma membrane [ISS]
    oocyte anterior/posterior axis specification [IMP]
    oocyte axis specification [IMP]
    establishment or maintenance of epithelial cell apical/basal polarity [IMP]
    establishment of cell polarity [IMP]
    establishment or maintenance of polarity of follicular epithelium [IMP]
    muscle attachment [IMP]
    Molecular Function: structural constituent of muscle [ISS]
    protein binding [IPI]
    calcium ion binding [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRFQWFLSAS ASLSLFLLLD FVVWIHGERD FNVNDSQVPV IEPKDVPAYK QDPYVTELMS  60
   61 CQNTPSEIVL SLLLKKHDWS ELTATKRAHV QAKLAKFFAI PKEFISLDSV SKRELRSMHK 120
  121 LAMRKGGKGN KNIETLNRRL GRASFMIGCG PSYFVMGEPI AKQIAHQMKD GTIGALTEEN 180
  181 FGLWFIWRKE LKSRSNRKRR QSEGSGADED DYDYGDDDEE VAEPSTEVPP VTTHAHRHHH 240
  241 GALEVSEKIV SPESVSSSAV PLVPDVEEEI EESVSKLESV ISKTIENTKN IKELPVLGEA 300
  301 DDGEDEEEVE LQQLGVPLAA EIVPDETTSA AATRATEMVK PVDLDEQEIS VDSGAVPAID 360
  361 VEASATPTPS MSARETQKPF SPYDATSSVS SSFSPVASIA SGSEAGEDST SVSTPHLSPA 420
  421 NSPTVMPTEL DRNGLATTSS SSSSSASPPP SSSVPTQATQ PTTSASSFSS SSSTTTTSTT 480
  481 ATVSTTTTAS STATTTTTTT TLSESPKEGG EPDAISSGNN SLANNELSTP ATPTSSVATT 540
  541 TASTPESSSI SSNFVSTDYM EPQPEENSPP IIKTRLQKLA VTSGKAFTFH VLPETFYDAE 600
  601 DQGNLRLALT DKDGHELKAN SWLQFNADKR ELYGLPLDDT VSRWQYRLSA TDSGNASVTE 660
  661 TVEISVQQHR AVRTINHEIS VFVRINEKPG HNIDWQLKLI NAVARTLDDS TNSAVVVREI 720
  721 RQTPHDPHSA TFVYFNETLP TSECPEKELK DIIARLDANR LSDLVQPQLG IKSITGQLIG 780
  781 SCQKDLTQVK PTQHMTKNVP PMPRNQVDRV NASLGQLLVY KVPADTFYDA NDNQLTLTLK 840
  841 TRDHLELSPR HWLQFDSKNE EFYGIPKSGD IGSEEYLLVA EDSGGLSAHD ALVVVVSPAP 900
  901 KRDFGFFFKA YLSIKHERFN ADLQRKFVER VAKLNGDPTT GQIQIRSITT HHDSDGTIVN 960
  961 FYNTTLYRKH NSCREKEVAM TRSVYLNSDL SLREAAKRAL GPELNLTNFS VVPFSICHHT1020
 1021 ENIDTNQLDY IPSRPEEPTH KSSFGEDYMI TFVWPIVIIV AMLVAASIIA CCLHWCRQRS1080
 1081 GKMELGDEEE RKSFRAKGIP VIFQDEYEEK PEIGNKSPVI LKDEKPPLLP PSYNTSNMNG1140
 1141 DNDVDDYVPP PSVVVGGREV RGKSPATPSY RKPPPYVSP

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..191] PSI-BLAST 42.69897 Crystal Structure of a-dystroglycan
    2 View Details [192..616] FFAS03 1.14 THE BLUETONGUE VIRUS (BTV) CORE BINDS DSRNA
    3 View Details [617..780] MSA 1.144983 View MSA. No confident structure predictions are available.
    4 View Details [781..1025] FFAS03 1.13 Crystal Structure of a-dystroglycan
    5 View Details [1026..1085] deduced N/A No confident structure predictions are available.
    6 View Details [1086..1179] MSA 1.013993 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • binding
    		•  1.57458227033664 bayes_pls_golite062009
  • cell adhesion molecule binding
    		•  1.20941485091826 bayes_pls_golite062009
  • protein binding
    		•  1.02797373424802 bayes_pls_golite062009
  • transporter activity
    		•  0.851228093937992 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  0.677581850277121 bayes_pls_golite062009
  • receptor activity
    		•  0.505108400296655 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.483421965826537 bayes_pls_golite062009
  • signal transducer activity
    		•  0.375469021130852 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.375469021130852 bayes_pls_golite062009
  • protein phosphatase binding
    		•  0.13438543889553 bayes_pls_golite062009
  • phosphatase binding
    		•  0.0613766967405507 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.
    4
    Term Confidence Notes
  • binding
    		•  1.69328197643368 bayes_pls_golite062009
  • protein binding
    		•  1.14884080540918 bayes_pls_golite062009
  • cell adhesion molecule binding
    		•  0.871842993993459 bayes_pls_golite062009
  • transporter activity
    		•  0.863724831300677 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  0.688682339597643 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.491786688714933 bayes_pls_golite062009
  • receptor activity
    		•  0.427379376489256 bayes_pls_golite062009
  • signal transducer activity
    		•  0.352492495963483 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.352492495963483 bayes_pls_golite062009
    5 No functions predicted.
    6 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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