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View Structure Prediction Details

Protein: Dg-PC
Organism: Drosophila melanogaster
Length: 1179 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for Dg-PC.

Description E-value Query
Range
Subject
Range
gi|18252636 - gi|18252636|gb|AAL66367.1|AF461099_1 dystroglycan type III [Drosophila melanogaster]
570.0 [0..489] [1179..224]

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Predicted Domain #1
Region A:
Residues: [1-191]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRFQWFLSAS ASLSLFLLLD FVVWIHGERD FNVNDSQVPV IEPKDVPAYK QDPYVTELMS  60
   61 CQNTPSEIVL SLLLKKHDWS ELTATKRAHV QAKLAKFFAI PKEFISLDSV SKRELRSMHK 120
  121 LAMRKGGKGN KNIETLNRRL GRASFMIGCG PSYFVMGEPI AKQIAHQMKD GTIGALTEEN 180
  181 FGLWFIWRKE L

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 42.69897
Match: 1u2cA
Description: Crystal Structure of a-dystroglycan
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 1.57458227033664 bayes_pls_golite062009
cell adhesion molecule binding 1.20941485091826 bayes_pls_golite062009
protein binding 1.02797373424802 bayes_pls_golite062009
transporter activity 0.851228093937992 bayes_pls_golite062009
transmembrane transporter activity 0.677581850277121 bayes_pls_golite062009
receptor activity 0.505108400296655 bayes_pls_golite062009
substrate-specific transporter activity 0.483421965826537 bayes_pls_golite062009
signal transducer activity 0.375469021130852 bayes_pls_golite062009
molecular transducer activity 0.375469021130852 bayes_pls_golite062009
protein phosphatase binding 0.13438543889553 bayes_pls_golite062009
phosphatase binding 0.0613766967405507 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [192-616]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KSRSNRKRRQ SEGSGADEDD YDYGDDDEEV AEPSTEVPPV TTHAHRHHHG ALEVSEKIVS  60
   61 PESVSSSAVP LVPDVEEEIE ESVSKLESVI SKTIENTKNI KELPVLGEAD DGEDEEEVEL 120
  121 QQLGVPLAAE IVPDETTSAA ATRATEMVKP VDLDEQEISV DSGAVPAIDV EASATPTPSM 180
  181 SARETQKPFS PYDATSSVSS SFSPVASIAS GSEAGEDSTS VSTPHLSPAN SPTVMPTELD 240
  241 RNGLATTSSS SSSSASPPPS SSVPTQATQP TTSASSFSSS SSTTTTSTTA TVSTTTTASS 300
  301 TATTTTTTTT LSESPKEGGE PDAISSGNNS LANNELSTPA TPTSSVATTT ASTPESSSIS 360
  361 SNFVSTDYME PQPEENSPPI IKTRLQKLAV TSGKAFTFHV LPETFYDAED QGNLRLALTD 420
  421 KDGHE

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 1.14
Match: 1h1kI
Description: THE BLUETONGUE VIRUS (BTV) CORE BINDS DSRNA
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [617-780]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LKANSWLQFN ADKRELYGLP LDDTVSRWQY RLSATDSGNA SVTETVEISV QQHRAVRTIN  60
   61 HEISVFVRIN EKPGHNIDWQ LKLINAVART LDDSTNSAVV VREIRQTPHD PHSATFVYFN 120
  121 ETLPTSECPE KELKDIIARL DANRLSDLVQ PQLGIKSITG QLIG

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [781-1025]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SCQKDLTQVK PTQHMTKNVP PMPRNQVDRV NASLGQLLVY KVPADTFYDA NDNQLTLTLK  60
   61 TRDHLELSPR HWLQFDSKNE EFYGIPKSGD IGSEEYLLVA EDSGGLSAHD ALVVVVSPAP 120
  121 KRDFGFFFKA YLSIKHERFN ADLQRKFVER VAKLNGDPTT GQIQIRSITT HHDSDGTIVN 180
  181 FYNTTLYRKH NSCREKEVAM TRSVYLNSDL SLREAAKRAL GPELNLTNFS VVPFSICHHT 240
  241 ENIDT

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 1.13
Match: 1u2cA
Description: Crystal Structure of a-dystroglycan
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 1.69328197643368 bayes_pls_golite062009
protein binding 1.14884080540918 bayes_pls_golite062009
cell adhesion molecule binding 0.871842993993459 bayes_pls_golite062009
transporter activity 0.863724831300677 bayes_pls_golite062009
transmembrane transporter activity 0.688682339597643 bayes_pls_golite062009
substrate-specific transporter activity 0.491786688714933 bayes_pls_golite062009
receptor activity 0.427379376489256 bayes_pls_golite062009
signal transducer activity 0.352492495963483 bayes_pls_golite062009
molecular transducer activity 0.352492495963483 bayes_pls_golite062009

Predicted Domain #5
Region A:
Residues: [1026-1085]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NQLDYIPSRP EEPTHKSSFG EDYMITFVWP IVIIVAMLVA ASIIACCLHW CRQRSGKMEL  60
   61 

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #6
Region A:
Residues: [1086-1179]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GDEEERKSFR AKGIPVIFQD EYEEKPEIGN KSPVILKDEK PPLLPPSYNT SNMNGDNDVD  60
   61 DYVPPPSVVV GGREVRGKSP ATPSYRKPPP YVSP

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle