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Protein Overview: Dg-PB

General Information:
Name(s) found: Dg-PB / FBpp0086395 [FlyBase]
Description(s) found:
Found 19 descriptions.
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  • The gene Dystroglycan is referred to in FlyBase by the symbol Dmel\Dg (CG18250, FBgn0034072). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:11968674..11986042. It has the cytological map location 52E2-52E4. There is experimental evidence that it has the molecular function</span>: protein binding. There is experimental evidence for 14 unique biological process</span> terms, many of which group under: anatomical structure development; cell morphogenesis; reproductive process in a multicellular organism; establishment or maintenance of cell polarity; organ morphogenesis; oocyte axis specification; organ development; synaptic transmission; muscle organ development; muscle homeostasis; establishment or maintenance of polarity of follicular epithelium; multicellular organism reproduction. 24 alleles are reported. The phenotypes of these alleles are annotated with: leg; posterior crossvein; eye; crossvein; follicle cell; wing. It has 3 annotated transcripts and 3 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 914 amino acids

    Gene Ontology:
    Cellular Component: T-tubule [IDA]
    basal plasma membrane [IDA]
    dystrophin-associated glycoprotein complex [IPI]
    dystroglycan complex [IDA][ISS][NAS]
    Biological Process: establishment or maintenance of apical/basal cell polarity [IMP]
    muscle cell homeostasis [IMP]
    regulation of synaptic activity [IMP]
    establishment or maintenance of cell polarity [IMP]
    growth of a germarium-derived egg chamber [IMP]
    sarcomere organization [IMP]
    axon guidance [IGI]
    imaginal disc-derived wing vein specification [IMP]
    cytoskeletal anchoring at plasma membrane [ISS]
    oocyte anterior/posterior axis specification [IMP]
    oocyte axis specification [IMP]
    establishment or maintenance of epithelial cell apical/basal polarity [IMP]
    establishment of cell polarity [IMP]
    establishment or maintenance of polarity of follicular epithelium [IMP]
    muscle attachment [IMP]
    Molecular Function: structural constituent of muscle [ISS]
    protein binding [IPI]
    calcium ion binding [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRFQWFLSAS ASLSLFLLLD FVVWIHGERD FNVNDSQVPV IEPKDVPAYK QDPYVTELMS  60
   61 CQNTPSEIVL SLLLKKHDWS ELTATKRAHV QAKLAKFFAI PKEFISLDSV SKRELRSMHK 120
  121 LAMRKGGKGN KNIETLNRRL GRASFMIGCG PSYFVMGEPI AKQIAHQMKD GTIGALTEEN 180
  181 FGLWFIWRKE LKSRSNRKRR QSEGSGADED DYDYGDDDEE VAEPSTEVPP VTTHAHRHHH 240
  241 GAEGGEPDAI SSGNNSLANN ELSTPATPTS SVATTTASTP ESSSISSNFV STDYMEPQPE 300
  301 ENSPPIIKTR LQKLAVTSGK AFTFHVLPET FYDAEDQGNL RLALTDKDGH ELKANSWLQF 360
  361 NADKRELYGL PLDDTVSRWQ YRLSATDSGN ASVTETVEIS VQQHRAVRTI NHEISVFVRI 420
  421 NEKPGHNIDW QLKLINAVAR TLDDSTNSAV VVREIRQTPH DPHSATFVYF NETLPTSECP 480
  481 EKELKDIIAR LDANRLSDLV QPQLGIKSIT GQLIGSCQKD LTQVKPTQHM TKNVPPMPRN 540
  541 QVDRVNASLG QLLVYKVPAD TFYDANDNQL TLTLKTRDHL ELSPRHWLQF DSKNEEFYGI 600
  601 PKSGDIGSEE YLLVAEDSGG LSAHDALVVV VSPAPKRDFG FFFKAYLSIK HERFNADLQR 660
  661 KFVERVAKLN GDPTTGQIQI RSITTHHDSD GTIVNFYNTT LYRKHNSCRE KEVAMTRSVY 720
  721 LNSDLSLREA AKRALGPELN LTNFSVVPFS ICHHTENIDT NQLDYIPSRP EEPTHKSSFG 780
  781 EDYMITFVWP IVIIVAMLVA ASIIACCLHW CRQRSGKMEL GDEEERKSFR AKGIPVIFQD 840
  841 EYEEKPEIGN KSPVILKDEK PPLLPPSYNT SNMNGDNDVD DYVPPPSVVV GGREVRGKSP 900
  901 ATPSYRKPPP YVSP

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..190] FFAS03 3.25 Crystal Structure of a-dystroglycan
    2 View Details [191..749] PSI-BLAST 74.0 W-shaped trans interactions of cadherins model based on fitting C-cadherin (1L3W) to 3D map of desmosomes obtained by electron tomography
    3 View Details [750..914] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • binding
    		•  1.53401809235127 bayes_pls_golite062009
  • protein binding
    		•  0.963310152550711 bayes_pls_golite062009
  • cell adhesion molecule binding
    		•  0.871842993993459 bayes_pls_golite062009
  • transporter activity
    		•  0.863724831300677 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  0.688682339597643 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.491786688714933 bayes_pls_golite062009
  • receptor activity
    		•  0.427379376489256 bayes_pls_golite062009
  • signal transducer activity
    		•  0.352492495963483 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.352492495963483 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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