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View Structure Prediction Details

Protein: Dg-PB
Organism: Drosophila melanogaster
Length: 914 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for Dg-PB.

Description E-value Query
Range
Subject
Range
gi|50512392, gi|... - gi|80751171|ref|NP_001032212.1| protocadherin gamma subfamily A, 10 [Rattus norvegicus], gi|50512392...
587.0 [0..188] [906..116]

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Predicted Domain #1
Region A:
Residues: [1-190]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRFQWFLSAS ASLSLFLLLD FVVWIHGERD FNVNDSQVPV IEPKDVPAYK QDPYVTELMS  60
   61 CQNTPSEIVL SLLLKKHDWS ELTATKRAHV QAKLAKFFAI PKEFISLDSV SKRELRSMHK 120
  121 LAMRKGGKGN KNIETLNRRL GRASFMIGCG PSYFVMGEPI AKQIAHQMKD GTIGALTEEN 180
  181 FGLWFIWRKE 

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 3.25
Match: 1u2cA
Description: Crystal Structure of a-dystroglycan
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 1.53401809235127 bayes_pls_golite062009
protein binding 0.963310152550711 bayes_pls_golite062009
cell adhesion molecule binding 0.871842993993459 bayes_pls_golite062009
transporter activity 0.863724831300677 bayes_pls_golite062009
transmembrane transporter activity 0.688682339597643 bayes_pls_golite062009
substrate-specific transporter activity 0.491786688714933 bayes_pls_golite062009
receptor activity 0.427379376489256 bayes_pls_golite062009
signal transducer activity 0.352492495963483 bayes_pls_golite062009
molecular transducer activity 0.352492495963483 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [191-749]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LKSRSNRKRR QSEGSGADED DYDYGDDDEE VAEPSTEVPP VTTHAHRHHH GAEGGEPDAI  60
   61 SSGNNSLANN ELSTPATPTS SVATTTASTP ESSSISSNFV STDYMEPQPE ENSPPIIKTR 120
  121 LQKLAVTSGK AFTFHVLPET FYDAEDQGNL RLALTDKDGH ELKANSWLQF NADKRELYGL 180
  181 PLDDTVSRWQ YRLSATDSGN ASVTETVEIS VQQHRAVRTI NHEISVFVRI NEKPGHNIDW 240
  241 QLKLINAVAR TLDDSTNSAV VVREIRQTPH DPHSATFVYF NETLPTSECP EKELKDIIAR 300
  301 LDANRLSDLV QPQLGIKSIT GQLIGSCQKD LTQVKPTQHM TKNVPPMPRN QVDRVNASLG 360
  361 QLLVYKVPAD TFYDANDNQL TLTLKTRDHL ELSPRHWLQF DSKNEEFYGI PKSGDIGSEE 420
  421 YLLVAEDSGG LSAHDALVVV VSPAPKRDFG FFFKAYLSIK HERFNADLQR KFVERVAKLN 480
  481 GDPTTGQIQI RSITTHHDSD GTIVNFYNTT LYRKHNSCRE KEVAMTRSVY LNSDLSLREA 540
  541 AKRALGPELN LTNFSVVPF

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 74.0
Match: 1q55A
Description: W-shaped trans interactions of cadherins model based on fitting C-cadherin (1L3W) to 3D map of desmosomes obtained by electron tomography
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [750-914]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SICHHTENID TNQLDYIPSR PEEPTHKSSF GEDYMITFVW PIVIIVAMLV AASIIACCLH  60
   61 WCRQRSGKME LGDEEERKSF RAKGIPVIFQ DEYEEKPEIG NKSPVILKDE KPPLLPPSYN 120
  121 TSNMNGDNDV DDYVPPPSVV VGGREVRGKS PATPSYRKPP PYVSP

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle