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Protein Overview: sbb-PF

General Information:
Name(s) found: sbb-PF / FBpp0290764 [FlyBase]
Description(s) found:
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  • gi|45552717|ref|NP_995883.1| scribbler, isoform B [Drosophila melanogaster] [NCBI NR]
  • gi|45445483|gb|AAS64812.1| scribbler, isoform B [Drosophila melanogaster] [NCBI NR]
  • The gene scribbler is referred to in FlyBase by the symbol Dmel\sbb (CG5580, FBgn0010575). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:14166570..14244766. It has the cytological map location 55C2-55C4. There is experimental evidence that it has the molecular function</span>: transcription corepressor activity. There is experimental evidence that it is involved in the biological process</span>: negative regulation of gene-specific transcription from RNA polymerase II promoter; axon guidance; wing disc dorsal/ventral pattern formation; imaginal disc-derived wing morphogenesis; axon target recognition; regulation of imaginal disc growth; larval locomotory behavior. 93 alleles are reported. The phenotypes of these alleles are annotated with 12 unique terms, many of which group under: adult segment; peripheral nervous system; organ system; nervous system; integumentary plate; thoracic segment; multi-cell-component structure; adult mesothoracic segment; dorsal thoracic disc; unguis. It has 6 annotated transcripts and 6 annotated polypeptides. [FlyBase]
  • (AAS64812) CG5580-PB [DrosMelano7227.FASTAC.txt]
  • CG5580-PB, isoform B [Drosophila melanogaster]gi|45552717|ref|NP_995883.1| CG5580-PB [Drosophila melanogaster] [nrdb_11152004_Chlamydomonas]
  • type=protein; loc=2R:complement(14172738..14175244,14175632..14175893,14177040..14177090); ID=FBpp0085946; name=sbb-PB; parent=FBgn0010575,FBtr0086767; dbxref=FlyBase:FBpp0085946,FlyBase_Annotation_IDs:CG5580-PB,GB_protein:AAS64812.1,REFSEQ:NP_995883,GB_p [fly-100309-contam.fasta]
  • CG5580-PB, isoform B [Drosophila melanogaster] [nr-271106-contam.fasta]
  • scribbler CG5580-PB, isoform B [Drosophila melanogaster] [nr-271106-contam.fasta]
  • type=protein; loc=2R:complement(14172738..14175244,14175632..14175893,14177040..14177090); ID=FBpp0085946; name=sbb-PB; parent=FBgn0010575,FBtr0086767; dbxref=FlyBase:FBpp0085946,FlyBase_Annotation_IDs:CG5580-PB,GB_protein:AAS64812.1,REFSEQ:NP_995883,GB_protein:AAS64812; MD5=2244cc0a7e9f187f626e7726c5c0530f; length=939; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta]
  • type=protein; loc=2R:complement(14172738..14175244,14175632..14175893,14177040..14177090); ID=FBpp0290764; name=sbb-PF; parent=FBgn0010575,FBtr0301549; dbxref=FlyBase:FBpp0290764,FlyBase_Annotation_IDs:CG5580-PF; MD5=2244cc0a7e9f187f626e7726c5c0530f; length=939; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta]
  • Scribbler, isoform F OS=Drosophila melanogaster GN=sbb PE=4 SV=1 [UniProt_drosophila_07-01-2011_reversed.fasta]
  • type=protein; loc=2R:complement(14172738..14175244,14175632..14175893,14177040..14177090); ID=FBpp0290764; name=sbb-PF; parent=FBgn0010575,FBtr0301549; dbxref=REFSEQ:NP_995883,GB_protein:AAS64812,FlyBase:FBpp0290764,FlyBase_Annotation_IDs:CG5580-PF,FlyMine:FBpp0290764,modMine:FBpp0290764; MD5=2244cc0a7e9f187f626e7726c5c0530f; length=939; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta]
  • type=protein; loc=2R:complement(join(18289535..18289585,18288127..18288388,18285233..18287739)); ID=FBpp0290764; name=sbb-PF; parent=FBgn0010575,FBtr0301549; dbxref=REFSEQ:NP_995883,GB_protein:AAS64812,FlyBase:FBpp0290764,FlyBase_Annotation_IDs:CG5580-PF,FlyMine:FBpp0290764,modMine:FBpp0290764; MD5=2244cc0a7e9f187f626e7726c5c0530f; length=939; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta]
  • type=protein; loc=2R:complement(join(18289535..18289585,18288127..18288388,18285233..18287739)); ID=FBpp0290764; name=sbb-PF; parent=FBgn0010575,FBtr0301549; dbxref=REFSEQ:NP_995883,GB_protein:AAS64812,FlyBase:FBpp0290764,FlyBase_Annotation_IDs:CG5580-PF,FlyMine:FBpp0290764,modMine:FBpp0290764; MD5=2244cc0a7e9f187f626e7726c5c0530f; length=939; release=r6.07; species=Dmel; [fly-08202015-contam.fasta]
  • Isoform of A0A0B4KEU2, Scribbler, isoform F OS=Drosophila melanogaster GN=sbb PE=4 SV=1 [DROME.fasta.20160308]
  • FBpp0290764 type=protein; loc=2R:complement(join(18289535..18289585,18288127..18288388,18285233..18287739)); ID=FBpp0290764; name=sbb-PF; parent=FBgn0010575,FBtr0301549; dbxref=REFSEQ:NP_995883,GB_protein:AAS64812,FlyBase:FBpp0290764,FlyBase_Annotation_IDs:CG5580-PF,FlyMine:FBpp0290764,modMine:FBpp0290764; MD5=2244cc0a7e9f187f626e7726c5c0530f; length=939; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta]
  • [fly-122215-dmel-6-09-contam.fasta]
  • type=protein; loc=2R:complement(join(18289535..18289585,18288127..18288388,18285233..18287739)); ID=FBpp0290764; name=sbb-PF; parent=FBgn0010575,FBtr0301549; dbxref=REFSEQ:NP_995883,GB_protein:AAS64812,FlyBase:FBpp0290764,FlyBase_Annotation_IDs:CG5580-PF,UniProt/TrEMBL:A1ZB51,FlyMine:FBpp0290764,modMine:FBpp0290764; MD5=2244cc0a7e9f187f626e7726c5c0530f; length=939; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
    • Organism: Drosophila melanogaster
    Length: 939 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDA][NAS]
    Biological Process: negative regulation of transcription from RNA polymerase II promoter [NAS]
    regulation of imaginal disc growth [IMP]
    photoreceptor cell development [NAS]
    imaginal disc-derived wing morphogenesis [IMP]
    axon guidance [IMP][NAS]
    larval locomotory behavior [IMP][TAS]
    wing disc dorsal/ventral pattern formation [IGI]
    axon target recognition [IMP]
    negative regulation of gene-specific transcription from RNA polymerase II promoter [IMP]
    Molecular Function: transcription factor activity [NAS]
    zinc ion binding [IEA]
    transcription corepressor activity [IDA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MESMRRNEAN TSHHPNKVAL NSSNVATESN IKNNKLLANL SAAGAATATT ATTGTATTTT  60
   61 ATTANQALNF NNKTKATANA TAASANNRHN NNNNSSAIKK HTNTKQLAGK SPACNSSSSS 120
  121 LSSSSSSNSS ESKDTNFEYE DEWNIGGIPE LLDDLDADIE KSAHSSGGGN QATALNAKQA 180
  181 NSSSTSSSSS SKGGASSSSS SAAATGSSSS HKSHKTTLHS NLSATSPTTI KFTRQPVAIG 240
  241 GANSSSSSSA AAAPSGGSAN VVAKGSSSSS SSTSSSSSGK HHHHHHHHSN SSSSGSSSKG 300
  301 YKSALVAQLN SPSPLNSNSK SLSGSGSGSG NTNGAAGAGA GSTLSSSTFA GFSKGGSLVS 360
  361 SSAGAAAALA AGSGQQGSKF SAGGMSSQTG SGSGGNNTSN SNNSSSGSGG SGSGSSTGNT 420
  421 ASGSGNNNST SAGGPPSSQG GNNGNGSGSS SSSSSGKSSA KMSIDHQATL DKGLKMKIKR 480
  481 TKPGTKSSEA KHEIVKATDQ QQNGALGAGS NNSANEDGSS GSSSTNASSL GSTNSSSSAS 540
  541 SGSSSSSGSS SSSSKKHLNN ASSGSGSSSS GGGSQNNASG HASGGGSSGS SQSTPQGTKR 600
  601 GSSGHRREKT KDKNAHSNRM SVDKSAAAAS AAGEKDTPEK CSGTGAGGSP CSCNGDVGAP 660
  661 CSHHACIRRA AHMSNSAGNA NSSAGTGQSG GSSSMSAVPP GVFTPSAGSP STGSPSTVVP 720
  721 AAASLLAATG AASSSASQMA SSSAGGVGGS GGGANAPGPP GKESAGSIKI SSHIAAQLAA 780
  781 AAASNSYSGS GANTNQGQNS NAGGNGGSES KAAAAAQAKL MAPGMISATM HHTISVPAGT 840
  841 GTGDDDTKSP PAKRVKHEAG ASGAGGGKEM VDICIGTSVG TITEPDCLGP CEPGTSVTLE 900
  901 GIVWHETEGG VLVVNVTWRG KTYVGTLLDC TRHDWAPPR

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..154] deduced N/A No confident structure predictions are available.
    2 View Details [155..371] deduced N/A No confident structure predictions are available.
    3 View Details [372..581] deduced N/A No confident structure predictions are available.
    4 View Details [582..682] deduced N/A No confident structure predictions are available.
    5 View Details [683..939] deduced N/A No confident structure predictions are available.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.84

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle