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Protein Overview: Tm1-PK

General Information:
Name(s) found: Tm1-PK / FBpp0088896 [FlyBase]
Description(s) found:
Found 19 descriptions.
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  • The gene Tropomyosin 1 is referred to in FlyBase by the symbol Dmel\Tm1 (CG4898, FBgn0003721). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:11107254..11133702. It has the cytological map location 88E12-88E13. Based on sequence similarity, it is predicted to have molecular function</span>: actin binding. There is experimental evidence that it is involved in the biological process</span>: regulation of lamellipodium assembly; dendrite morphogenesis; pole plasm oskar mRNA localization. 50 alleles are reported. The phenotypes of these alleles are annotated with: pole cell; germline cell. It has 13 annotated transcripts and 13 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 518 amino acids

    Gene Ontology:
    Cellular Component: muscle thin filament tropomyosin [NAS]
    sarcomere [IDA]
    Biological Process: regulation of lamellipodium assembly [IMP]
    oogenesis [TAS]
    muscle contraction [NAS]
    pole plasm oskar mRNA localization [IMP][TAS]
    pole plasm assembly [NAS]
    dendrite morphogenesis [IMP][TAS]
    Molecular Function: actin binding [ISS][TAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDAIKKKMQA MKVDKDGALE RALVCEQEAR DANTRAEKAE EEARQLQKKI QTVENELDQT  60
   61 QEALTLVTGK LEEKNKALQN AESEVAALNR RIQLLEEDLE RSEERLGSAT AKLSEASQAA 120
  121 DESERARKIL ENRALADEER MDALENQLKE ARFLAEEADK KYDEVARKLA MVEADLERAE 180
  181 ERAEQGENKI VELEEELRVV GNNLKSLEVS EEKANQREEE YKNQIKTLNT RLKEAEARAE 240
  241 FAERSVQKLQ KEVDRLEDDL IVEKERYCMI GDSLDEAFVD LIKGLEPFWN PRNPKPPTPK 300
  301 LPTPTPEELA AMEEARAAAE AAAAAEAEAA EAAAAAGEAG PDGAPAAPGE EKAPAKEPTP 360
  361 PKEPTPPPPP PPPFEYSIDL PPEGAEVPYV KNYEPPPPGS EPEPVPAAEG EAAPAAEGAA 420
  421 PPAEGAAPPA EGAVPPADGA APPAEGAAPA AEGAAPPADG AAPPAEAAAA PADAAAPAAE 480
  481 AAPAEAPAAE ATAAEAPPAE AAPAEAAPAA AEGEAPPA

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..295] PSI-BLAST 37.30103 Tropomyosin
    2 View Details [296..456] FFAS03 1.34 No description for 2j63A was found.
    3 View Details [457..518] deduced N/A No confident structure predictions are available.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle