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Protein Overview: Tm1-PB

General Information:
Name(s) found: Tm1-PB / FBpp0088897 [FlyBase]
Description(s) found:
Found 15 descriptions.
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  • The gene Tropomyosin 1 is referred to in FlyBase by the symbol Dmel\Tm1 (CG4898, FBgn0003721). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:11107254..11133702. It has the cytological map location 88E12-88E13. Based on sequence similarity, it is predicted to have molecular function</span>: actin binding. There is experimental evidence that it is involved in the biological process</span>: regulation of lamellipodium assembly; dendrite morphogenesis; pole plasm oskar mRNA localization. 50 alleles are reported. The phenotypes of these alleles are annotated with: pole cell; germline cell. It has 13 annotated transcripts and 13 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 339 amino acids

    Gene Ontology:
    Cellular Component: muscle thin filament tropomyosin [NAS]
    sarcomere [IDA]
    Biological Process: regulation of lamellipodium assembly [IMP]
    oogenesis [TAS]
    muscle contraction [NAS]
    pole plasm oskar mRNA localization [IMP][TAS]
    pole plasm assembly [NAS]
    dendrite morphogenesis [IMP][TAS]
    Molecular Function: actin binding [ISS][TAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDAIKKKMQA MKVDKDGALE RALVCEQEAR DANTRAEKAE EEARQLQKKI QTVENELDQT  60
   61 QEALTLVTGK LEEKNKALQN KKKTTKMTTS IPQGTLLDVL KKKMRQTKEE MEKYKDECEE 120
  121 FHKRLQLEVV RREEAESEVA ALNRRIQLLE EDLERSEERL GSATAKLSEA SQAADESERA 180
  181 RKILENRALA DEERMDALEN QLKEARFLAE EADKKYDEVA RKLAMVEADL ERAEERAEQG 240
  241 ENKIVELEEE LRVVGNNLKS LEVSEEKANQ REEEYKNQIK TLNTRLKEAE ARAEFAERSV 300
  301 QKLQKEVDRL EDDLVLEKER YKDIGDDLDT AFVELILKE

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..63] PSI-BLAST 4.154902 No description for 2fxmA was found.
    2 View Details [64..339] PSI-BLAST 37.221849 Tropomyosin


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle