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Protein Overview: gfA-PC

General Information:
Name(s) found: gfA-PC / FBpp0089249 [FlyBase]
Description(s) found:
Found 13 descriptions.
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  • The gene giant fibre A is referred to in FlyBase by the symbol Dmel\gfA (CG32538, FBgn0086778). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:19222594..19242477. It has the cytological map location 18C2-18C3. Based on sequence similarity, it is predicted to have molecular function</span>: nicotinic acetylcholine-activated cation-selective channel activity. There is experimental evidence that it is involved in the biological process</span>: synaptic transmission; regulation of excitatory postsynaptic membrane potential; visual behavior; jump response. 23 alleles are reported. The phenotype of these alleles is annotated with: giant fibers. It has 4 annotated transcripts and 4 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 219 amino acids

    Gene Ontology:
    Cellular Component: dendrite [IDA]
    postsynaptic membrane [IEA]
    dendritic spine [IDA]
    integral to membrane [IEA]
    nicotinic acetylcholine-gated receptor-channel complex [ISS][NAS]
    Biological Process: ion transport [IEA]
    regulation of excitatory postsynaptic membrane potential [IMP]
    jump response [IMP]
    synaptic transmission [IMP]
    visual behavior [IMP]
    Molecular Function: nicotinic acetylcholine-activated cation-selective channel activity [ISS][NAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKKPSRSRPD NPSCPGQDRT RSMSFPQPHS LPEATANGGR MLVYGLGLLI MIPACAAGPH  60
   61 EKRLLHALLD NYNSLERPVV NESDPLQLSF GLTLMQIIDV DEKNQLLITN IWLKLEWNDM 120
  121 NLRWNSSEFG GVRDLRIPPH RLWKPDVLMY NSADEGFDGT YATNVVVRNN GSCLYVPPGI 180
  181 FKSTCKIDIT WFPFDDQRCE MKFGSWTYDG FQVTTQLLS

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..219] PSI-BLAST 46.39794 Refined structure of the nicotinic acetylcholine receptor at 4A resolution.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.44

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle