Protein Overview: GUCA2A

General Information:
Name(s) found:	GUCA2A [HGNC (HUGO)]
Description(s) found: SHOW ONLY BEST	gi\|38176149\|ref\|NP_291031.2\| guanylate cyclase activator 2A [Homo sapiens] [NCBI NR] gi\|119627573\|gb\|EAX07168.1\| guanylate cyclase activator 2A (guanylin) [Homo sapiens] [NCBI NR] guanylate cyclase activator 2A (guanylin) [HGNC (HUGO)] Guanylin OS=Homo sapiens GN=GUCA2A PE=1 SV=2 [Swiss-Prot] guanylate cyclase activator 2A; guanylate cyclase activator 2A (guanylin 2, intestinal, heat-stable) [HMR_022704.fasta] guanylate cyclase activator 2A [Homo sapiens] [nrdb_11152004_Chlamydomonas] guanylate cyclase activator 2A; guanylate cyclase activator 2A (guanylin 2, intestinal, heat-stable) [Homo sapiens] [HumanGallus06162005.fasta] guanylate cyclase activator 2A (guanylin) [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta] guanylate cyclase activator 2A precursor [Homo sapiens] [NCBI-RefSeq_human_na_10-19-2009_con_reversed.fasta] [human_BMb_040710_contam.fasta] Tax_Id=9606 Gene_Symbol=GUCA2A Guanylin [EBI-IPI_Human_3.71_03-24-2010_reversed.fasta] guanylin precursor [Homo sapiens] [NCBI-RefSeq_Human_na_04-23-2010_reversed.fasta] Q02747; RecName: Full=Guanylin; AltName: Full=Guanylate cyclase activator 2A; AltName: Full=Guanylate cyclase-activating protein 1; AltName: Full=Guanylate cyclase-activating protein I; Contains: RecName: Full=HMW-guanylin; Contains: RecName: Full=Guanylin; Flags: Precursor; [UniProt_Human_2010_06_06-01-2010_reversed.fasta] Guanylin OS=Homo sapiens GN=GUCA2A [011711_HMR.fasta] IPI:IPI00026926.2\|SWISS-PROT:Q02747\|ENSEMBL:ENSP00000349493\|REFSEQ:NP_291031\|H-INV:HIT000196959\|VEGA:OTTHUMP00000007926 Tax_Id=9606 Gene_Symbol=GUCA2A Guanylin [ipi.HUMAN.fasta.20100406] GeneSymbol=GUCA2A Synonyms=GCAP-I\|GUCA2\|STARA guanylin precursor [Homo sapiens] [NCBI-RefSeq_Human_Seno_07-12-2011_reversed.fasta] Guanylin GN=GUCA2A [Doctor+uniprot-HUMAN-120911.fasta]
Organism:	Homo sapiens
Length:	115 amino acids
Gene Ontology:
Cellular Component:	NONE FOUND
Biological Process:	NONE FOUND
Molecular Function:	NONE FOUND

Sequence:
Sequence: [PDR BLAST] [ProtParam]	1 11 21 31 41 51 \| \| \| \| \| \| 1 MNAFLLSALC LLGAWAALAG GVTVQDGNFS FSLESVKKLK DLQEPQEPRV GKLRNFAPIP 60 61 GEPVVPILCS NPNFPEELKP LCKEPNAQEI LQRLEEIAED PGTCEICAYA ACTGC

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Microscopy / Localization Data

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No microscopy data found in the PDR for this protein.

Protein Structure Data

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Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..115]	PSI-BLAST	39.0	Proguanylin

Functions predicted (by domain):

#

Gene Ontology predictions

1

Term	Confidence	Notes
cyclase activator activity	0.15716290490412	bayes_pls_golite062009
guanylate cyclase activator activity	0.15716290490412	bayes_pls_golite062009
binding	0.126525777428077	bayes_pls_golite062009
cyclase regulator activity	0.0605060481810804	bayes_pls_golite062009
guanylate cyclase regulator activity	0.0605060481810804	bayes_pls_golite062009

Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

Philius Transmembrane Prediction:

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Source: Reynolds et al. 2008. Manuscript submitted

Philius confidence legend

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