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View Structure Prediction Details

Protein: GUCA2A
Organism: Homo sapiens
Length: 115 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for GUCA2A.

Description E-value Query
Range		 Subject
Range
gi|114555875 - gi|114555875|ref|XP_001172840.1| PREDICTED: similar to guanylin isoform 2 [Pan troglodytes]
 1.0E-47 [1..115] [1..115]
GUC2A_NOTAL - Guanylin OS=Notomys alexis GN=GUCA2A PE=3 SV=1
 1.0E-43 [1..115] [1..115]
GUC2A_RAT - Guanylin OS=Rattus norvegicus GN=Guca2a PE=1 SV=1
 2.0E-43 [1..115] [1..115]
GUC2A_MOUSE - Guanylin OS=Mus musculus GN=Guca2a PE=2 SV=1
 1.0E-42 [1..115] [1..116]
GUCA2A - guanylate cyclase activator 2A (guanylin)
 1.0E-42 [1..115] [1..115]
gi|109003241 - gi|109003241|ref|XP_001085421.1| PREDICTED: similar to guanylate cyclase activator 2A [Macaca mulatt...
 6.0E-41 [15..115] [15..115]
gi|1835224 - gi|1835224|emb|CAA97974.1| GCAP-I/guanylin precursor [Sus scrofa domestica]
GUC2A_PIG - Guanylin OS=Sus scrofa GN=GUCA2A PE=3 SV=1
 3.0E-40 [1..115] [1..109]
gi|73976735 - gi|73976735|ref|XP_539563.2| PREDICTED: similar to guanylate cyclase activator 2A [Canis familiaris]
 4.0E-39 [1..115] [454..564]
GUC2A_CAVPO - Guanylin OS=Cavia porcellus GN=GUCA2A PE=3 SV=1
 2.0E-38 [1..115] [1..107]

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Predicted Domain #1
Region A:
Residues: [1-115] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNAFLLSALC LLGAWAALAG GVTVQDGNFS FSLESVKKLK DLQEPQEPRV GKLRNFAPIP  60
   61 GEPVVPILCS NPNFPEELKP LCKEPNAQEI LQRLEEIAED PGTCEICAYA ACTGC

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 39.0
Match: 1o8rA
Description: Proguanylin
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
cyclase activator activity 0.15716290490412 bayes_pls_golite062009
guanylate cyclase activator activity 0.15716290490412 bayes_pls_golite062009
binding 0.126525777428077 bayes_pls_golite062009
cyclase regulator activity 0.0605060481810804 bayes_pls_golite062009
guanylate cyclase regulator activity 0.0605060481810804 bayes_pls_golite062009
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle