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Protein Overview: MIF

General Information:
Name(s) found: MIF [HGNC (HUGO)]
Description(s) found:
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  • gi|83026417|gb|ABB96245.1| macrophage migration inhibitory factor (glycosylation-inhibiting factor) [Homo sapiens] [NCBI NR]
  • gi|47678571|emb|CAG30406.1| MIF [Homo sapiens] [NCBI NR]
  • gi|47115225|emb|CAG28572.1| MIF [Homo sapiens] [NCBI NR]
  • gi|4505185|ref|NP_002406.1| macrophage migration inhibitory factor [Homo sapiens] [NCBI NR]
  • gi|402702|gb|AAA35892.1| glycosylation-inhibiting factor [NCBI NR]
  • gi|31419739|gb|AAH53376.1| Macrophage migration inhibitory factor (glycosylation-inhibiting factor) [Homo sapiens] [NCBI NR]
  • gi|312334|emb|CAA80598.1| macrophage migration inhibitory factor [Homo sapiens] [NCBI NR]
  • gi|307285|gb|AAA21814.1| macrophage migration inhibitory factor [Homo sapiens] [NCBI NR]
  • gi|30583135|gb|AAP35812.1| macrophage migration inhibitory factor (glycosylation-inhibiting factor) [Homo sapiens] [NCBI NR]
  • pir||A48793 glycosylation-inhibiting factor - human [NCBI NR]
  • gi|1942171|pdb|1GIF|C Chain C, Human Glycosylation-Inhibiting Factor [NCBI NR]
  • gi|1942170|pdb|1GIF|B Chain B, Human Glycosylation-Inhibiting Factor [NCBI NR]
  • gi|1942169|pdb|1GIF|A Chain A, Human Glycosylation-Inhibiting Factor [NCBI NR]
  • gi|189065147|dbj|BAG34870.1| unnamed protein product [Homo sapiens] [NCBI NR]
  • gi|18699569|gb|AAL78635.1|AF469046_1 macrophage migration inhibitory factor [Homo sapiens] [NCBI NR]
  • gi|18490869|gb|AAH22414.1| Macrophage migration inhibitory factor (glycosylation-inhibiting factor) [Homo sapiens] [NCBI NR]
  • gi|15559243|gb|AAH13976.1| Macrophage migration inhibitory factor (glycosylation-inhibiting factor) [Homo sapiens] [NCBI NR]
  • gi|14286236|gb|AAH08914.1| Macrophage migration inhibitory factor (glycosylation-inhibiting factor) [Homo sapiens] [NCBI NR]
  • gi|14043367|gb|AAH07676.1| Macrophage migration inhibitory factor (glycosylation-inhibiting factor) [Homo sapiens] [NCBI NR]
  • gi|12653355|gb|AAH00447.1| Macrophage migration inhibitory factor (glycosylation-inhibiting factor) [Homo sapiens] [NCBI NR]
  • gi|119580024|gb|EAW59620.1| macrophage migration inhibitory factor (glycosylation-inhibiting factor) [Homo sapiens] [NCBI NR]
  • gi|1170955|sp|P14174.4|MIF_HUMAN RecName: Full=Macrophage migration inhibitory factor; Short=MIF; AltName: Full=Phenylpyruvate tautomerase; AltName: Full=L-dopachrome tautomerase; AltName: Full=L-dopachrome isomerase; AltName: Full=Glycosylation-inhibitin [NCBI NR]
  • macrophage migration inhibitory factor (glycosylation-inhibiting factor) [HGNC (HUGO)]
  • Macrophage migration inhibitory factor OS=Homo sapiens GN=MIF PE=1 SV=4 [Swiss-Prot]
  • macrophage migration inhibitory factor (glycosylation-inhibiting factor); glycosylation-inhibiting factor; phenylpyruvate tautomerase [HMR_022704.fasta]
  • macrophage migration inhibitory factor (glycosylation-inhibiting factor); phenylpyruvate tautomerase; glycosylation-inhibiting factor [Human2242005.fasta]
  • macrophage migration inhibitory factor (glycosylation-inhibiting factor) [Homo sapiens]gi|30583135|gb|AAP35812.1| macrophage migration inhibitory factor (glycosylation-inhibiting factor) [Homo sapiens]gi|31419739|gb|AAH53376.1| Macrophage migration inhi [nrdb_11152004_Chlamydomonas]
  • Macrophage migration inhibitory factor (MIF) (Phenylpyruvate tautomerase) (Glycosylation-inhibiting factor) (GIF) [Yateslab_human_na_07-28-2006_reversed.fasta]
  • (NM_002415) macrophage migration inhibitory factor (glycosylation-inhibiting factor); glycosylation-inhibiting factor; macrophage migration inhibitory factor; phenylpyruvate tautomerase [Homo sapiens] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta]
  • macrophage migration inhibitory factor (glycosylation-inhibiting factor) [Homo sapiens] [NCBI-RefSeq_Human_na_12_06_2006_con_reversed.fasta]
  • macrophage migration inhibitory factor (glycosylation-inhibiting factor); phenylpyruvate tautomerase; glycosylation-inhibiting factor [Homo sapiens] [HumanGallus06162005.fasta]
  • macrophage migration inhibitory factor (glycosylation-inhibiting factor); glycosylation-inhibiting factor; phenylpyruvate tautomerase [Homo sapiens] [human-NCBI-042104-rand.fasta]
  • MIF [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Chain C, Human Glycosylation-Inhibiting Factor [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Chain B, Human Glycosylation-Inhibiting Factor [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Chain A, Human Glycosylation-Inhibiting Factor [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • unnamed protein product [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • macrophage migration inhibitory factor [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Macrophage migration inhibitory factor (glycosylation-inhibiting factor) [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • glycosylation-inhibiting factor [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • macrophage migration inhibitory factor [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • RecName: Full=Macrophage migration inhibitory factor; Short=MIF; AltName: Full=Phenylpyruvate tautomerase; AltName: Full=Glycosylation-inhibiting factor; Short=GIF [NCBI-RefSeq_human_na_10-15-2008_con_reversed.fasta]
  • Tax_Id=9606 Gene_Symbol=LOC284889;MIF Macrophage migration inhibitory factor [human-ipi-250309-contam.fasta]
  • IPI:IPI00293276.10|SWISS-PROT:P14174|TREMBL:A6MUU8|ENSEMBL:ENSP00000215754|REFSEQ:NP_002406|H-INV:HIT000039526|VEGA:OTTHUMP00000028932;OTTHUMP00000198465 Tax_Id=9606 Gene_Symbol=MIF Macrophage migration inhibitory factor [ipi.HUMAN.fasta.20090807]
  • Tax_Id=9606 Macrophage migration inhibitory factor [IPI_human_3.26.fasta]
  • [human_BMb_040710_contam.fasta]
  • Tax_Id=9606 Gene_Symbol=MIF Macrophage migration inhibitory factor ENSG00000099964 IPI00293276 IPI00790382 [drosphohumanreversed.fasta]
  • Tax_Id=9606 Gene_Symbol=MIF Macrophage migration inhibitory factor [EBI-IPI_human_3.30_06-28-2007_con_reversed.fasta]
  • P14174;A5Z1R8;B2R4S3;Q2V4Y5;Q6FHV0; RecName: Full=Macrophage migration inhibitory factor; AltName: Full=Phenylpyruvate tautomerase; AltName: Full=L-dopachrome tautomerase; AltName: Full=L-dopachrome isomerase; AltName: Full=Glycosylation-inhibiting factor; [UniProt_Human_2010_06_06-01-2010_reversed.fasta]
  • Macrophage migration inhibitory factor OS=Homo sapiens GN=MIF [011711_HMR.fasta]
  • GeneSymbol=MIF Synonyms=GIF|GLIF|MMIF macrophage migration inhibitory factor [Homo sapiens] [NCBI-RefSeq_Human_Seno_07-12-2011_reversed.fasta]
  • IPI:IPI00293276.10|SWISS-PROT:P14174|TREMBL:A6MUU8|ENSEMBL:ENSP00000215754|REFSEQ:NP_002406|VEGA:OTTHUMP00000198465 Tax_Id=9606 Gene_Symbol=MIF Macrophage migration inhibitory factor [ipi.HUMAN.20110912.fasta]
  • Macrophage migration inhibitory factor GN=MIF [Doctor+uniprot-HUMAN-120911.fasta]
  • Macrophage migration inhibitory factor (Fragment) OS=Homo sapiens PE=2 SV=1 [uniprot-human-031015-contam.fasta]
    • Organism: Homo sapiens
    Length: 115 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPMFIVNTNV PRASVPDGFL SELTQQLAQA TGKPPQYIAV HVVPDQLMAF GGSSEPCALC  60
   61 SLHSIGKIGG AQNRSYSKLL CGLLAERLRI SPDRVYINYY DMNAANVGWN NSTFA

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..115] PSI-BLAST 54.522879 Microphage migration inhibition factor (MIF)

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • phenylpyruvate tautomerase activity
    		•  3.84932786282501 bayes_pls_golite062009
  • cytokine activity
    		•  2.80410252537768 bayes_pls_golite062009
  • intramolecular oxidoreductase activity
    		•  2.17252244354636 bayes_pls_golite062009
  • binding
    		•  1.9717928129965 bayes_pls_golite062009
  • receptor binding
    		•  1.79096938850925 bayes_pls_golite062009
  • protein binding
    		•  1.70051621352839 bayes_pls_golite062009
  • catalytic activity
    		•  0.836951613125537 bayes_pls_golite062009
  • isomerase activity
    		•  0.804529932513639 bayes_pls_golite062009
  • intramolecular oxidoreductase activity, transposing C=C bonds
    		•  0.452407074010503 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle