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Protein Overview: MAN1A1

General Information:
Name(s) found: MAN1A1 [HGNC (HUGO)]
Description(s) found:
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  • gi|62906886|sp|P33908.3|MA1A1_HUMAN RecName: Full=Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA; AltName: Full=Processing alpha-1,2-mannosidase IA; Short=Alpha-1,2-mannosidase IA; AltName: Full=Mannosidase alpha class 1A member 1; AltName: Full=Man(9) [NCBI NR]
  • gi|56203652|emb|CAB75695.2| mannosidase, alpha, class 1A, member 1 [Homo sapiens] [NCBI NR]
  • gi|56202626|emb|CAI20315.1| mannosidase, alpha, class 1A, member 1 [Homo sapiens] [NCBI NR]
  • gi|24497519|ref|NP_005898.2| mannosidase, alpha, class 1A, member 1 [Homo sapiens] [NCBI NR]
  • gi|119568572|gb|EAW48187.1| mannosidase, alpha, class 1A, member 1, isoform CRA_c [Homo sapiens] [NCBI NR]
  • mannosidase, alpha, class 1A, member 1 [HGNC (HUGO)]
  • Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA OS=Homo sapiens GN=MAN1A1 PE=1 SV=3 [Swiss-Prot]
  • mannosidase, alpha, class 1A, member 1; Man9-mannosidase; alpha-1,2-mannosidase IA; mannosyl-oligosaccharide 1,2-alpha-mannosidase IA [HMR_022704.fasta]
  • mannosidase, alpha, class 1A, member 1 [Homo sapiens] [nrdb_11152004_Chlamydomonas]
  • Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA (Processing alpha-1,2-mannosidase IA) (Alpha-1,2-mannosidase IA) (Mannosidase alpha class 1A member 1) (Man(9)-alpha-mannosidase) (Man9-mannosidase) [Yateslab_human_na_07-28-2006_reversed.fasta]
  • Tax_Id=9606 Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA [EBI-IPI_human_3.17_05-09-2006_con_reversed.fasta]
  • mannosidase, alpha, class 1A, member 1; Man9-mannosidase; alpha-1,2-mannosidase IA; mannosyl-oligosaccharide 1,2-alpha-mannosidase IA [Homo sapiens] [HumanGallus06162005.fasta]
  • mannosidase, alpha, class 1A, member 1, isoform CRA_c [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Tax_Id=9606 Gene_Symbol=MAN1A1 Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA [human-ipi-250309-contam.fasta]
  • MAN1A1 [Homo sapiens] [nr-271106-contam.fasta]
  • IPI:IPI00844511.1|SWISS-PROT:P33908|ENSEMBL:ENSP00000357453|REFSEQ:NP_005898|H-INV:HIT000008873|VEGA:OTTHUMP00000017107 Tax_Id=9606 Gene_Symbol=MAN1A1 Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA [ipi.HUMAN.fasta.20090807]
  • [human_BMb_040710_contam.fasta]
  • mannosyl-oligosaccharide 1,2-alpha-mannosidase IA [Homo sapiens] [NCBI-RefSeq_Human_na_04-23-2010_reversed.fasta]
  • P33908;Q9NU44;Q9UJI3; RecName: Full=Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA; AltName: Full=Processing alpha-1,2-mannosidase IA; AltName: Full=Mannosidase alpha class 1A member 1; AltName: Full=Man(9)-alpha-mannosidase; [UniProt_Human_2010_06_06-01-2010_reversed.fasta]
  • Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA OS=Homo sapiens GN=MAN1A1 [011711_HMR.fasta]
  • GeneSymbol=MAN1A1 Synonyms=HUMM3|HUMM9|MAN9 mannosyl-oligosaccharide 1,2-alpha-mannosidase IA [Homo sapiens] [NCBI-RefSeq_Human_Seno_07-12-2011_reversed.fasta]
  • Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA GN=MAN1A1 [Doctor+uniprot-HUMAN-120911.fasta]
    • Organism: Homo sapiens
    Length: 653 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPVGGLLPLF SSPAGGVLGG GLGGGGGRKG SGPAALRLTE KFVLLLVFSA FITLCFGAIF  60
   61 FLPDSSKLLS GVLFHSSPAL QPAADHKPGP GARAEDAAEG RARRREEGAP GDPEAALEDN 120
  121 LARIRENHER ALREAKETLQ KLPEEIQRDI LLEKKKVAQD QLRDKAPFRG LPPVDFVPPI 180
  181 GVESREPADA AIREKRAKIK EMMKHAWNNY KGYAWGLNEL KPISKGGHSS SLFGNIKGAT 240
  241 IVDALDTLFI MEMKHEFEEA KSWVEENLDF NVNAEISVFE VNIRFVGGLL SAYYLSGEEI 300
  301 FRKKAVELGV KLLPAFHTPS GIPWALLNMK SGIGRNWPWA SGGSSILAEF GTLHLEFMHL 360
  361 SHLSGNPIFA EKVMNIRTVL NKLEKPQGLY PNYLNPSSGQ WGQHHVSVGG LGDSFYEYLL 420
  421 KAWLMSDKTD LEAKKMYFDA VQAIETHLIR KSSSGLTYIA EWKGGLLEHK MGHLTCFAGG 480
  481 MFALGADAAP EGMAQHYLEL GAEIARTCHE SYNRTFMKLG PEAFRFDGGV EAIATRQNEK 540
  541 YYILRPEVME TYMYMWRLTH DPKYRKWAWE AVEALENHCR VNGGYSGLRD VYLLHESYDD 600
  601 VQQSFFLAET LKYLYLIFSD DDLLPLEHWI FNSEAHLLPI LPKDKKEVEI REE

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..62] deduced N/A No confident structure predictions are available.
    2 View Details [63..174] MSA 1.152996 View MSA. No confident structure predictions are available.
    3 View Details [175..653] PSI-BLAST 1000.0 Structure of mouse Golgi alpha-1,2-mannosidase IA reveals the molecular basis for substrate specificity among Class I enzymes (family 47 glycosidases)

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • mannosyl-oligosaccharide mannosidase activity
    		•  7.089685350864 bayes_pls_golite062009
  • mannosyl-oligosaccharide 1,2-alpha-mannosidase activity
    		•  6.95179264736435 bayes_pls_golite062009
  • mannosidase activity
    		•  5.20286438265852 bayes_pls_golite062009
  • hydrolase activity, hydrolyzing O-glycosyl compounds
    		•  4.31319275372149 bayes_pls_golite062009
  • hydrolase activity, acting on glycosyl bonds
    		•  3.65589746311782 bayes_pls_golite062009
  • hydrolase activity
    		•  2.67964748309919 bayes_pls_golite062009
  • binding
    		•  1.49199031708525 bayes_pls_golite062009
  • catalytic activity
    		•  1.31873306707813 bayes_pls_golite062009
  • cation binding
    		•  0.362242764130218 bayes_pls_golite062009
  • metal ion binding
    		•  0.362242764130218 bayes_pls_golite062009
  • protein binding
    		•  0.36081692928767 bayes_pls_golite062009
  • ion binding
    		•  0.355220167272296 bayes_pls_golite062009
  • calcium ion binding
    		•  0.121126738064555 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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