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Protein Overview: MED27

General Information:
Name(s) found: MED27 [HGNC (HUGO)]
Description(s) found:
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  • gi|74737195|sp|Q6P2C8.1|MED27_HUMAN RecName: Full=Mediator of RNA polymerase II transcription subunit 27; AltName: Full=Mediator complex subunit 27; AltName: Full=Cofactor required for Sp1 transcriptional activation subunit 8; AltName: Full=CRSP complex s [NCBI NR]
  • gi|40555882|gb|AAH64608.1| Mediator complex subunit 27 [Homo sapiens] [NCBI NR]
  • gi|28558979|ref|NP_004260.2| mediator complex subunit 27 [Homo sapiens] [NCBI NR]
  • gi|123266995|emb|CAI13386.2| mediator complex subunit 27 [Homo sapiens] [NCBI NR]
  • gi|123242498|emb|CAH72529.2| mediator complex subunit 27 [Homo sapiens] [NCBI NR]
  • gi|123232927|emb|CAH72546.2| mediator complex subunit 27 [Homo sapiens] [NCBI NR]
  • gi|123226309|emb|CAI17283.2| mediator complex subunit 27 [Homo sapiens] [NCBI NR]
  • gi|119608399|gb|EAW87993.1| cofactor required for Sp1 transcriptional activation, subunit 8, 34kDa, isoform CRA_b [Homo sapiens] [NCBI NR]
  • gi|119608396|gb|EAW87990.1| cofactor required for Sp1 transcriptional activation, subunit 8, 34kDa, isoform CRA_b [Homo sapiens] [NCBI NR]
  • mediator complex subunit 27 [HGNC (HUGO)]
  • Mediator of RNA polymerase II transcription subunit 27 OS=Homo sapiens GN=MED27 PE=1 SV=1 [Swiss-Prot]
  • CRSP complex subunit 8 (Cofactor required for Sp1 transcriptional activation subunit 8) (Transcriptional coactivator CRSP34) (P37 TRAP/SMCC/PC2 subunit) - Homo sapiens (Human) [Swiss-Prot]
  • cofactor required for Sp1 transcriptional activation, subunit 8, 34kDa; p37 TRAP/SMCC/PC2 subunit [HMR_022704.fasta]
  • cofactor required for Sp1 transcriptional activation, subunit 8, 34kDa; p37 TRAP/SMCC/PC2 subunit; cofactor required for Sp1 transcriptional activation, subunit 8 (34kD) [071204_hmrz_cont.fasta]
  • cofactor required for Sp1 transcriptional activation, subunit 8, 34kDa [Homo sapiens]gi|40555882|gb|AAH64608.1| Cofactor required for Sp1 transcriptional activation, subunit 8, 34kDa [Homo sapiens] [nrdb_11152004_Chlamydomonas]
  • Tax_Id=9606 Splice Isoform 1 of CRSP complex subunit 8 [EBI-IPI_human_3.17_05-09-2006_con_reversed.fasta]
  • cofactor required for Sp1 transcriptional activation, subunit 8, 34kDa [Homo sapiens] [NCBI-RefSeq_Human_na_12_06_2006_con_reversed.fasta]
  • Tax_Id=9606 Cofactor required for Sp1 transcriptional activation, subunit 8, 34kDa [EBI-IPI_human_3.04_03-07-2005_reverse.fasta]
  • cofactor required for Sp1 transcriptional activation, subunit 8, 34kDa; p37 TRAP/SMCC/PC2 subunit; cofactor required for Sp1 transcriptional activation, subunit 8 (34kD) [Homo sapiens] [HumanGallus06162005.fasta]
  • cofactor required for Sp1 transcriptional activation, subunit 8, 34kDa; p37 TRAP/SMCC/PC2 subunit [Homo sapiens] [human-NCBI-042104-rand.fasta]
  • Mediator of RNA polymerase II transcription subunit 27 (Mediator complex subunit 27) (Cofactor required for Sp1 transcriptional activation subunit 8) (CRSP complex subunit 8) (Transcriptional coactivator CRSP34) (P37 TRAP/SMCC/PC2 subunit) [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • mediator complex subunit 27 [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Mediator complex subunit 27 [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • cofactor required for Sp1 transcriptional activation, subunit 8, 34kDa, isoform CRA_b [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Tax_Id=9606 Isoform 1 of CRSP complex subunit 8 [EBI-IPI_human_3.23_11-02-2006_con_reversed.fasta]
  • Tax_Id=9606 COFACTOR REQUIRED FOR SP1 TRANSCRIPTIONAL ACTIVATION, SUBUNIT 8, 34KDA [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta]
  • Tax_Id=9606 Gene_Symbol=MED27 Isoform 1 of Mediator of RNA polymerase II transcription subunit 27 [human-ipi-250309-contam.fasta]
  • Cofactor required for Sp1 transcriptional activation, subunit 8, 34kDa [Homo sapiens] [nr-271106-contam.fasta]
  • CRSP complex subunit 8 (Cofactor required for Sp1 transcriptional activation subunit 8) (Transcriptional coactivator CRSP34) (P37 TRAP/SMCC/PC2 subunit) [nr-271106-contam.fasta]
  • IPI:IPI00302652.3|SWISS-PROT:Q6P2C8-1|TREMBL:B4DPP5|ENSEMBL:ENSP00000292035|REFSEQ:NP_004260|H-INV:HIT000261527|VEGA:OTTHUMP00000022426 Tax_Id=9606 Gene_Symbol=MED27 Isoform 1 of Mediator of RNA polymerase II transcription subunit 27 [ipi.HUMAN.fasta.20090807]
  • [human_BMb_040710_contam.fasta]
  • Tax_Id=9606 Gene_Symbol=MED27 Isoform 1 of Mediator of RNA polymerase II transcription subunit 27 ENSG00000160563 IPI00302652 IPI00455649 IPI00788820 [drosphohumanreversed.fasta]
  • Tax_Id=9606 Gene_Symbol=CRSP8 Isoform 1 of CRSP complex subunit 8 [EBI-IPI_human_3.30_06-28-2007_con_reversed.fasta]
  • mediator of RNA polymerase II transcription subunit 27 [Homo sapiens] [NCBI-RefSeq_Human_na_04-23-2010_reversed.fasta]
  • Q6P2C8;O95401;Q4F964;Q5VTA4;Q5VTA5;Q9BU57;Q9NYR4; RecName: Full=Mediator of RNA polymerase II transcription subunit 27; AltName: Full=Mediator complex subunit 27; AltName: Full=Cofactor required for Sp1 transcriptional activation subunit 8; AltName: Full=Transcriptional coactivator CRSP34; AltName: Full=P37 TRAP/SMCC/PC2 subunit; [UniProt_Human_2010_06_06-01-2010_reversed.fasta]
  • Isoform 1 of Mediator of RNA polymerase II transcription subunit 27 OS=Homo sapiens GN=MED27 [011711_HMR.fasta]
  • Mediator of RNA polymerase II transcription subunit 27 n=11 Tax=Tetrapoda RepID=MED27_HUMAN [UniProt_Xenopus_laevis_01-01-2011_reversed.fasta]
  • GeneSymbol=MED27 Synonyms=CRAP34|CRSP34|CRSP8|MGC11274|TRAP37 mediator of RNA polymerase II transcription subunit 27 [Homo sapiens] [NCBI-RefSeq_Human_Seno_07-12-2011_reversed.fasta]
  • Mediator of RNA polymerase II transcription subunit 27 GN=MED27 [Doctor+uniprot-HUMAN-120911.fasta]
  • Cofactor required for Sp1 transcriptional activation, subunit 8, 34kDa, isoform CRA_b OS=Homo sapiens GN=CRSP8 PE=4 SV=1 [uniprot-human-031015-contam.fasta]
    • Organism: Homo sapiens
    Length: 311 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MADVINVSVN LEAFSQAISA IQALRSSVSR VFDCLKDGMR NKETLEGREK AFIAHFQDNL  60
   61 HSVNRDLNEL ERLSNLVGKP SENHPLHNSG LLSLDPVQDK TPLYSQLLQA YKWSNKLQYH 120
  121 AGLASGLLNQ QSLKRSANQM GVSAKRRPKA QPTTLVLPPQ YVDDVISRID RMFPEMSIHL 180
  181 SRPNGTSAML LVTLGKVLKV IVVMRSLFID RTIVKGYNEN VYTEDGKLDI WSKSNYQVFQ 240
  241 KVTDHATTAL LHYQLPQMPD VVVRSFMTWL RSYIKLFQAP CQRCGKFLQD GLPPTWRDFR 300
  301 TLEAFHDTCR Q

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..118] MSA 1.007973 View MSA. Confident ab initio structure predictions are available.
    2 View Details [119..225] deduced N/A No confident structure predictions are available.
    3 View Details [226..311] MSA 2.007985 View MSA. Confident ab initio structure predictions are available.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.93

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle