YRC Public Data Repository - Protein Structure Prediction

Protein:	MED27
Organism:	Homo sapiens
Length:	311 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for MED27.

Description	E-value	Query Range	Subject Range
tr\|G3I9P4\|G3I9P4... - Mediator of RNA polymerase II transcription subunit 27 OS=Cricetulus griseus GN=I79_020298 PE=4 SV=1 MED27_PIG - Mediator of RNA polymerase II transcription subunit 27 OS=Sus scrofa GN=MED27 PE=2 SV=1	597.0	[0..1]	[311..1]
MED27_BOVIN - Mediator of RNA polymerase II transcription subunit 27 OS=Bos taurus GN=MED27 PE=2 SV=1	595.0	[0..1]	[311..1]
gi\|157818903, gi... - gi\|62644833\|ref\|XP_216025.3\| PREDICTED: similar to transcriptional co-activator CRSP8 homolog [Rattu...	595.0	[0..1]	[311..1]
MED27_MOUSE - Mediator of RNA polymerase II transcription subunit 27 OS=Mus musculus GN=Med27 PE=2 SV=2	594.0	[0..1]	[311..1]
gi\|73967722 - gi\|73967722\|ref\|XP_849826.1\| PREDICTED: similar to cofactor required for Sp1 transcriptional activat...	594.0	[0..1]	[311..1]
gi\|109109978 - gi\|109109978\|ref\|XP_001105126.1\| PREDICTED: similar to cofactor required for Sp1 transcriptional act...	593.0	[0..1]	[311..1]
gi\|50757265 - gi\|50757265\|ref\|XP_415455.1\| PREDICTED: similar to cofactor required for Sp1 transcriptional activat...	571.0	[0..1]	[311..33]
gi\|55624172 - gi\|55624172\|ref\|XP_526874.1\| PREDICTED: similar to cofactor required for Sp1 transcriptional activat...	571.0	[0..1]	[311..1]
MED27_XENTR - Mediator of RNA polymerase II transcription subunit 27 OS=Xenopus tropicalis GN=med27 PE=2 SV=1	569.0	[0..1]	[311..1]
MED27_DANRE - Mediator of RNA polymerase II transcription subunit 27 OS=Danio rerio GN=med27 PE=2 SV=1	564.0	[0..1]	[311..1]

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Predicted Domain #1

Region A:
Residues: [1-118]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MADVINVSVN LEAFSQAISA IQALRSSVSR VFDCLKDGMR NKETLEGREK AFIAHFQDNL  60
   61 HSVNRDLNEL ERLSNLVGKP SENHPLHNSG LLSLDPVQDK TPLYSQLLQA YKWSNKLQ

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

		MCM Score	GO Score	GO Term	SCOP Match	SCOP Description
View	Download	0.879	N/A	N/A	a.7.8	GAT domain

Predicted Domain #2

Region A:
Residues: [119-225]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YHAGLASGLL NQQSLKRSAN QMGVSAKRRP KAQPTTLVLP PQYVDDVISR IDRMFPEMSI  60
   61 HLSRPNGTSA MLLVTLGKVL KVIVVMRSLF IDRTIVKGYN ENVYTED

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3

Region A:
Residues: [226-311]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GKLDIWSKSN YQVFQKVTDH ATTALLHYQL PQMPDVVVRS FMTWLRSYIK LFQAPCQRCG  60
   61 KFLQDGLPPT WRDFRTLEAF HDTCRQ

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

		MCM Score	GO Score	GO Term	SCOP Match	SCOP Description
View	Download	0.836	N/A	N/A	a.7.2	Enzyme IIa from lactose specific PTS, IIa-lac

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits