YRC Logo
PROTEIN SEARCH:
Descriptions Names[Advanced Search]

View Structure Prediction Details

Protein: MED27
Organism: Homo sapiens
Length: 311 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



[What does the above image mean?]


[Show Ginzu Version Information]


Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for MED27.

Description E-value Query
Range
Subject
Range
tr|G3I9P4|G3I9P4... - Mediator of RNA polymerase II transcription subunit 27 OS=Cricetulus griseus GN=I79_020298 PE=4 SV=1
MED27_PIG - Mediator of RNA polymerase II transcription subunit 27 OS=Sus scrofa GN=MED27 PE=2 SV=1
597.0 [0..1] [311..1]
MED27_BOVIN - Mediator of RNA polymerase II transcription subunit 27 OS=Bos taurus GN=MED27 PE=2 SV=1
595.0 [0..1] [311..1]
gi|157818903, gi... - gi|62644833|ref|XP_216025.3| PREDICTED: similar to transcriptional co-activator CRSP8 homolog [Rattu...
595.0 [0..1] [311..1]
MED27_MOUSE - Mediator of RNA polymerase II transcription subunit 27 OS=Mus musculus GN=Med27 PE=2 SV=2
594.0 [0..1] [311..1]
gi|73967722 - gi|73967722|ref|XP_849826.1| PREDICTED: similar to cofactor required for Sp1 transcriptional activat...
594.0 [0..1] [311..1]
gi|109109978 - gi|109109978|ref|XP_001105126.1| PREDICTED: similar to cofactor required for Sp1 transcriptional act...
593.0 [0..1] [311..1]
gi|50757265 - gi|50757265|ref|XP_415455.1| PREDICTED: similar to cofactor required for Sp1 transcriptional activat...
571.0 [0..1] [311..33]
gi|55624172 - gi|55624172|ref|XP_526874.1| PREDICTED: similar to cofactor required for Sp1 transcriptional activat...
571.0 [0..1] [311..1]
MED27_XENTR - Mediator of RNA polymerase II transcription subunit 27 OS=Xenopus tropicalis GN=med27 PE=2 SV=1
569.0 [0..1] [311..1]
MED27_DANRE - Mediator of RNA polymerase II transcription subunit 27 OS=Danio rerio GN=med27 PE=2 SV=1
564.0 [0..1] [311..1]

Back

Predicted Domain #1
Region A:
Residues: [1-118]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MADVINVSVN LEAFSQAISA IQALRSSVSR VFDCLKDGMR NKETLEGREK AFIAHFQDNL  60
   61 HSVNRDLNEL ERLSNLVGKP SENHPLHNSG LLSLDPVQDK TPLYSQLLQA YKWSNKLQ

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.879 N/A N/A a.7.8 GAT domain
View Download 0.849 N/A N/A a.7.1 Spectrin repeat
View Download 0.819 N/A N/A a.47.2 t-snare proteins
View Download 0.799 N/A N/A a.24.9 alpha-catenin/vinculin
View Download 0.798 N/A N/A a.29.13 Description not found.
View Download 0.757 N/A N/A a.7.1 Spectrin repeat
View Download 0.749 N/A N/A a.24.9 alpha-catenin/vinculin
View Download 0.669 N/A N/A a.7.7 BAG domain
View Download 0.621 N/A N/A a.24.14 FAT domain of focal adhesion kinase
View Download 0.583 N/A N/A a.45.1 Glutathione S-transferase (GST), C-terminal domain

Predicted Domain #2
Region A:
Residues: [119-225]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YHAGLASGLL NQQSLKRSAN QMGVSAKRRP KAQPTTLVLP PQYVDDVISR IDRMFPEMSI  60
   61 HLSRPNGTSA MLLVTLGKVL KVIVVMRSLF IDRTIVKGYN ENVYTED

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.690 d.189.1 PX domain
View Download 0.647 a.2.7 tRNA-binding arm
View Download 0.613 d.189.1 PX domain
View Download 0.604 a.121.1 Tetracyclin repressor-like, C-terminal domain
View Download 0.595 a.7.6 Ribosomal protein S20
View Download 0.494 a.40.1 Calponin-homology domain, CH-domain
View Download 0.455 a.2.7 tRNA-binding arm
View Download 0.350 d.189.1 PX domain
View Download 0.336 a.7.6 Ribosomal protein S20
View Download 0.322 a.2.3 Chaperone J-domain

Predicted Domain #3
Region A:
Residues: [226-311]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GKLDIWSKSN YQVFQKVTDH ATTALLHYQL PQMPDVVVRS FMTWLRSYIK LFQAPCQRCG  60
   61 KFLQDGLPPT WRDFRTLEAF HDTCRQ

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.836 N/A N/A a.7.2 Enzyme IIa from lactose specific PTS, IIa-lac
View Download 0.828 N/A N/A a.7.2 Enzyme IIa from lactose specific PTS, IIa-lac
View Download 0.821 N/A N/A a.7.8 GAT domain
View Download 0.817 N/A N/A a.7.2 Enzyme IIa from lactose specific PTS, IIa-lac
View Download 0.766 N/A N/A a.7.12 Description not found.
View Download 0.723 N/A N/A a.2.8 Eukaryotic DNA topoisomerase I, dispensable insert domain
View Download 0.717 N/A N/A a.7.8 GAT domain
View Download 0.694 N/A N/A a.2.8 Eukaryotic DNA topoisomerase I, dispensable insert domain
View Download 0.690 N/A N/A a.7.2 Enzyme IIa from lactose specific PTS, IIa-lac


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle