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Protein Overview: IL1B

General Information:
Name(s) found: IL1B [HGNC (HUGO)]
Description(s) found:
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  • pir||ICHU1B interleukin-1 beta precursor [validated] - human [NCBI NR]
  • gi|62906858|sp|P01584.2|IL1B_HUMAN RecName: Full=Interleukin-1 beta; Short=IL-1 beta; AltName: Full=Catabolin; Flags: Precursor [NCBI NR]
  • gi|62630143|gb|AAX88888.1| unknown [Homo sapiens] [NCBI NR]
  • gi|386816|gb|AAA74137.1| interleukin 1-beta [Homo sapiens] [NCBI NR]
  • gi|35663|emb|CAA39567.1| prointerleukin-1 beta [Homo sapiens] [NCBI NR]
  • gi|33790|emb|CAA26372.1| unnamed protein product [Homo sapiens] [NCBI NR]
  • gi|312408|emb|CAA28185.1| prointerleukin-1-beta [Homo sapiens] [NCBI NR]
  • gi|307045|gb|AAA59135.1| interleukin 1-beta [Homo sapiens] [NCBI NR]
  • gi|30583265|gb|AAP35877.1| interleukin 1, beta [Homo sapiens] [NCBI NR]
  • gi|28317372|tpe|CAD29872.1| TPA: pro-interleukin-1-beta [Homo sapiens] [NCBI NR]
  • gi|224528|prf||1107273B interleukin 1beta [NCBI NR]
  • gi|22122010|gb|AAM88883.1| interleukin 1, beta [Homo sapiens] [NCBI NR]
  • gi|14250477|gb|AAH08678.1| Interleukin 1, beta [Homo sapiens] [NCBI NR]
  • gi|119594011|gb|EAW73605.1| interleukin 1, beta, isoform CRA_a [Homo sapiens] [NCBI NR]
  • gi|10835145|ref|NP_000567.1| interleukin 1, beta proprotein [Homo sapiens] [NCBI NR]
  • interleukin 1, beta [HGNC (HUGO)]
  • Interleukin-1 beta OS=Homo sapiens GN=IL1B PE=1 SV=2 [Swiss-Prot]
  • interleukin 1, beta proprotein; preinterleukin 1 beta; catabolin [HMR_022704.fasta]
  • interleukin 1, beta proprotein [Homo sapiens]gi|30583265|gb|AAP35877.1| interleukin 1, beta [Homo sapiens]gi|22122010|gb|AAM88883.1| interleukin 1, beta [Homo sapiens]gi|14250477|gb|AAH08678.1| Interleukin 1, beta, proprotein [Homo sapiens]gi|28317372 [nrdb_11152004_Chlamydomonas]
  • Interleukin-1 beta precursor (IL-1 beta) (Catabolin) [Yateslab_human_na_07-28-2006_reversed.fasta]
  • Tax_Id=9606 Interleukin-1 beta precursor [EBI-IPI_human_3.17_05-09-2006_con_reversed.fasta]
  • (NM_000576) interleukin 1, beta [Homo sapiens] [NCBI-RefSeq_human-mouse-rat_na_10-18-2006_con_reversed.fasta]
  • interleukin 1, beta proprotein [Homo sapiens] [NCBI-RefSeq_Human_na_12_06_2006_con_reversed.fasta]
  • interleukin 1, beta proprotein; preinterleukin 1 beta; catabolin [Homo sapiens] [HumanGallus06162005.fasta]
  • interleukin 1, beta, isoform CRA_a [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • TPA: pro-interleukin-1-beta [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • prointerleukin-1-beta [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Interleukin 1, beta [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • unknown [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • interleukin 1, beta [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • prointerleukin-1 beta [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • interleukin 1beta [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • unnamed protein product [Homo sapiens] [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • interleukin 1-beta [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Tax_Id=9606 PRO-INTERLEUKIN-1-BETA [Xentr4_EBI-IPI_human_mouse_rat_Xenopus_tropicalis_laevis_con_reversed.fasta]
  • RecName: Full=Interleukin-1 beta; Short=IL-1 beta; AltName: Full=Catabolin; Flags: Precursor [NCBI-RefSeq_human_na_10-15-2008_con_reversed.fasta]
  • Tax_Id=9606 Gene_Symbol=IL1B Interleukin-1 beta [human-ipi-250309-contam.fasta]
  • IPI:IPI00307223.6|SWISS-PROT:P01584|TREMBL:B5BUQ8;O43645|ENSEMBL:ENSP00000263341|REFSEQ:NP_000567|H-INV:HIT000194388|VEGA:OTTHUMP00000162031 Tax_Id=9606 Gene_Symbol=IL1B Interleukin-1 beta [ipi.HUMAN.fasta.20090807]
  • [human_BMb_040710_contam.fasta]
  • Tax_Id=9606 Gene_Symbol=IL1B Interleukin-1 beta precursor ENSG00000125538 IPI00307223 [drosphohumanreversed.fasta]
  • Tax_Id=9606 Gene_Symbol=IL1B Interleukin-1 beta precursor [EBI-IPI_human_3.30_06-28-2007_con_reversed.fasta]
  • P01584;Q53X59;Q53XX2;Q7M4S7;Q7RU01;Q96HE5;Q9UCT6; RecName: Full=Interleukin-1 beta; AltName: Full=Catabolin; Flags: Precursor; [UniProt_Human_2010_06_06-01-2010_reversed.fasta]
  • Interleukin-1 beta OS=Homo sapiens GN=IL1B [011711_HMR.fasta]
  • GeneSymbol=IL1B Synonyms=IL-1|IL1-BETA|IL1F2 interleukin-1 beta proprotein [Homo sapiens] [NCBI-RefSeq_Human_Seno_07-12-2011_reversed.fasta]
  • Interleukin-1 beta GN=IL1B [Doctor+uniprot-HUMAN-120911.fasta]
    • Organism: Homo sapiens
    Length: 269 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAEVPELASE MMAYYSGNED DLFFEADGPK QMKCSFQDLD LCPLDGGIQL RISDHHYSKG  60
   61 FRQAASVVVA MDKLRKMLVP CPQTFQENDL STFFPFIFEE EPIFFDTWDN EAYVHDAPVR 120
  121 SLNCTLRDSQ QKSLVMSGPY ELKALHLQGQ DMEQQVVFSM SFVQGEESND KIPVALGLKE 180
  181 KNLYLSCVLK DDKPTLQLES VDPKNYPKKK MEKRFVFNKI EINNKLEFES AQFPNWYIST 240
  241 SQAENMPVFL GGTKGGQDIT DFTMQFVSS

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..99] Pfam 62.420216 No description for PF02394.7 was found. No confident structure predictions are available.
    2 View Details [100..269] PSI-BLAST 59.221849 CRYSTAL STRUCTURE OF RECOMBINANT HUMAN INTERLEUKIN-1BETA AT 2.0 ANGSTROMS RESOLUTION

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • growth factor activity
    		•  5.6790632853895 bayes_pls_golite062009
  • cytokine activity
    		•  4.92514805273922 bayes_pls_golite062009
  • receptor binding
    		•  4.8109037277027 bayes_pls_golite062009
  • fibroblast growth factor receptor binding
    		•  3.82623893122433 bayes_pls_golite062009
  • protein binding
    		•  2.99442649109752 bayes_pls_golite062009
  • glycosaminoglycan binding
    		•  2.49177421879896 bayes_pls_golite062009
  • binding
    		•  2.47177194764362 bayes_pls_golite062009
  • heparin binding
    		•  2.1616134585534 bayes_pls_golite062009
  • interleukin-1 receptor binding
    		•  2.01634458410435 bayes_pls_golite062009
  • polysaccharide binding
    		•  1.81686028727894 bayes_pls_golite062009
  • chemoattractant activity
    		•  1.42155423144626 bayes_pls_golite062009
  • interleukin-1, Type I receptor binding
    		•  0.909481376669721 bayes_pls_golite062009
  • pattern binding
    		•  0.323275442862789 bayes_pls_golite062009
  • nerve growth factor receptor binding
    		•  0.308245352535379 bayes_pls_golite062009
  • tumor necrosis factor receptor superfamily binding
    		•  0.0626824359203906 bayes_pls_golite062009
  • transporter activity
    		•  0.0547618159251159 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle