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View Structure Prediction Details

Protein: IL1B
Organism: Homo sapiens
Length: 269 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for IL1B.

Description E-value Query
Range
Subject
Range
gi|114579639 - gi|114579639|ref|XP_001146939.1| PREDICTED: hypothetical protein isoform 2 [Pan troglodytes]
0.0 [1..269] [32..300]
gi|61371045, gi|... - gi|61371045|gb|AAX43599.1| interleukin 1 beta [synthetic construct], gi|61371042|gb|AAX43598.1| inte...
0.0 [1..269] [1..269]
IL1B - interleukin 1, beta
0.0 [1..269] [1..269]
gi|15213526 - gi|15213526|gb|AAK92041.1|AF294754_1 interleukin-1 beta [Saimiri sciureus]
0.0 [1..269] [1..269]
IL1B_MACNE - Interleukin-1 beta OS=Macaca nemestrina GN=IL1B PE=2 SV=1
0.0 [1..269] [1..269]
IL1B_MACMU - Interleukin-1 beta OS=Macaca mulatta GN=IL1B PE=2 SV=1
0.0 [1..269] [1..269]
IL1B_MACFA - Interleukin-1 beta OS=Macaca fascicularis GN=IL1B PE=2 SV=1
0.0 [1..268] [1..268]

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Predicted Domain #1
Region A:
Residues: [1-99]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAEVPELASE MMAYYSGNED DLFFEADGPK QMKCSFQDLD LCPLDGGIQL RISDHHYSKG  60
   61 FRQAASVVVA MDKLRKMLVP CPQTFQENDL STFFPFIFE

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 62.420216
Match: PF02394.7
Description: No description for PF02394.7 was found.

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [100-269]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EEPIFFDTWD NEAYVHDAPV RSLNCTLRDS QQKSLVMSGP YELKALHLQG QDMEQQVVFS  60
   61 MSFVQGEESN DKIPVALGLK EKNLYLSCVL KDDKPTLQLE SVDPKNYPKK KMEKRFVFNK 120
  121 IEINNKLEFE SAQFPNWYIS TSQAENMPVF LGGTKGGQDI TDFTMQFVSS 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 59.221849
Match: 1i1bA
Description: CRYSTAL STRUCTURE OF RECOMBINANT HUMAN INTERLEUKIN-1BETA AT 2.0 ANGSTROMS RESOLUTION
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
growth factor activity 5.6790632853895 bayes_pls_golite062009
cytokine activity 4.92514805273922 bayes_pls_golite062009
receptor binding 4.8109037277027 bayes_pls_golite062009
fibroblast growth factor receptor binding 3.82623893122433 bayes_pls_golite062009
protein binding 2.99442649109752 bayes_pls_golite062009
glycosaminoglycan binding 2.49177421879896 bayes_pls_golite062009
binding 2.47177194764362 bayes_pls_golite062009
heparin binding 2.1616134585534 bayes_pls_golite062009
interleukin-1 receptor binding 2.01634458410435 bayes_pls_golite062009
polysaccharide binding 1.81686028727894 bayes_pls_golite062009
chemoattractant activity 1.42155423144626 bayes_pls_golite062009
interleukin-1, Type I receptor binding 0.909481376669721 bayes_pls_golite062009
pattern binding 0.323275442862789 bayes_pls_golite062009
nerve growth factor receptor binding 0.308245352535379 bayes_pls_golite062009
tumor necrosis factor receptor superfamily binding 0.0626824359203906 bayes_pls_golite062009
transporter activity 0.0547618159251159 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle