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Protein Overview: Tm2-PC

General Information:
Name(s) found: Tm2-PC / FBpp0089270 [FlyBase]
Description(s) found:
Found 24 descriptions.
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  • The gene Tropomyosin 2 is referred to in FlyBase by the symbol Dmel\Tm2 (CG4843, FBgn0004117). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:11135915..11140920. It has the cytological map location 88E13. Based on sequence similarity, it is predicted to have molecular function</span>: actin binding. There is experimental evidence that it is involved in the biological process</span>: heart development. 28 alleles are reported. The phenotypes of these alleles are annotated with: myofibril; adult heart; heart chamber; indirect flight muscle. It has 3 annotated transcripts and 3 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 284 amino acids

    Gene Ontology:
    Cellular Component: muscle thin filament tropomyosin [NAS]
    Biological Process: heart development [IMP]
    Molecular Function: actin binding [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDAIKKKMQA MKLEKDNAID KADTCENQAK DANSRADKLN EEVRDLEKKF VQVEIDLVTA  60
   61 KEQLEKANTE LEEKEKLLTA TESEVATQNR KVQQIEEDLE KSEERSTTAQ QKLLEATQSA 120
  121 DENNRMCKVL ENRSQQDEER MDQLTNQLKE ARMLAEDADT KSDEVSRKLA FVEDELEVAE 180
  181 DRVRSGESKI MELEEELKVV GNSLKSLEVS EEKANQRVEE FKREMKTLSI KLKEAEQRAE 240
  241 HAEKQVKRLQ KEVDRLEDRL FNEKEKYKAI CDDLDQTFAE LTGY

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..284] PSI-BLAST 34.39794 Tropomyosin


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle