Protein Overview: tld-PA

General Information:
Name(s) found:	tld-PA / FBpp0084070 [FlyBase]
Description(s) found: SHOW ONLY BEST	gi\|51338722\|sp\|P25723.2\|TLD_DROME RecName: Full=Dorsal-ventral patterning protein tolloid; Flags: Precursor [NCBI NR] gi\|45549230\|ref\|NP_524487.2\| tolloid [Drosophila melanogaster] [NCBI NR] gi\|45446640\|gb\|AAF56329.2\| tolloid [Drosophila melanogaster] [NCBI NR] Dorsal-ventral patterning protein tolloid OS=Drosophila melanogaster GN=tld PE=2 SV=2 [Swiss-Prot] The gene tolloid is referred to in FlyBase by the symbol Dmel\tld (CG6868, FBgn0003719). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:20575456..20579234. It has the cytological map location 96A19. There is experimental evidence that it has the molecular function</span>: specific transcriptional repressor activity. There is experimental evidence that it is involved in the biological process</span>: torso signaling pathway; terminal region determination; imaginal disc-derived wing vein morphogenesis; maternal specification of dorsal/ventral axis, oocyte, soma encoded; protein maturation by peptide bond cleavage. 93 alleles are reported. The phenotypes of these alleles are annotated with 14 unique terms, many of which group under: organ system; adult segment; adult mesothoracic segment; extended germ band embryo; nervous system; portion of tissue; thoracic segment; gastrula embryo; intracellular non-membrane-bounded organelle; primordium; external compound sense organ; late extended germ band embryo. It has one annotated transcript and one annotated polypeptide. [FlyBase] (AAF56329) CG6868-PA [DrosMelano7227.FASTAC.txt] CG6868-PA [Drosophila melanogaster]gi\|45549230\|ref\|NP_524487.2\| CG6868-PA [Drosophila melanogaster]gi\|51338722\|sp\|P25723\|TLD_DROME Dorsal-ventral patterning tolloid protein precursor [nrdb_11152004_Chlamydomonas] type=protein; loc=3R:join(20575518..20575715,20575778..20575839,20575985..20576329,20576384..20577204,20577256..20577517,20577571..20578139,20578196..20579142); ID=FBpp0084070; name=tld-PA; parent=FBgn0003719,FBtr0084691; dbxref=GB_protein:AAF56329.1,FlyB [fly-100309-contam.fasta] CG6868-PA [Drosophila melanogaster] [nr-271106-contam.fasta] Dorsal-ventral patterning protein tolloid precursor [nr-271106-contam.fasta] tolloid CG6868-PA [Drosophila melanogaster] [nr-271106-contam.fasta] type=protein; loc=3R:join(20575518..20575715,20575778..20575839,20575985..20576329,20576384..20577204,20577256..20577517,20577571..20578139,20578196..20579142); ID=FBpp0084070; name=tld-PA; parent=FBgn0003719,FBtr0084691; dbxref=GB_protein:AAF56329.1,FlyBase:FBpp0084070,FlyBase_Annotation_IDs:CG6868-PA,GB_protein:AAF56329.2,REFSEQ:NP_524487,GB_protein:AAF56329; MD5=14eb76ccfd62c80f78390a3357c36734; length=1067; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta] type=protein; loc=3R:join(20575518..20575715,20575778..20575839,20575985..20576329,20576384..20577204,20577256..20577517,20577571..20578139,20578196..20579142); ID=FBpp0084070; name=tld-PA; parent=FBgn0003719,FBtr0084691; dbxref=GB_protein:AAF56329.1,FlyBase:FBpp0084070,FlyBase_Annotation_IDs:CG6868-PA,GB_protein:AAF56329.2,REFSEQ:NP_524487,GB_protein:AAF56329; MD5=14eb76ccfd62c80f78390a3357c36734; length=1067; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta] Dorsal-ventral patterning protein tolloid OS=Drosophila melanogaster GN=tld PE=1 SV=2 [UniProt_drosophila_07-01-2011_reversed.fasta] type=protein; loc=3R:join(20575518..20575715,20575778..20575839,20575985..20576329,20576384..20577204,20577256..20577517,20577571..20578139,20578196..20579142); ID=FBpp0084070; name=tld-PA; parent=FBgn0003719,FBtr0084691; dbxref=GB_protein:AAF56329.1,FlyBase:FBpp0084070,FlyBase_Annotation_IDs:CG6868-PA,GB_protein:AAF56329.2,REFSEQ:NP_524487,GB_protein:AAF56329,FlyMine:FBpp0084070,modMine:FBpp0084070; MD5=14eb76ccfd62c80f78390a3357c36734; length=1067; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta] type=protein; loc=3R:join(24749796..24749993,24750056..24750117,24750263..24750607,24750662..24751482,24751534..24751795,24751849..24752417,24752474..24753420); ID=FBpp0084070; name=tld-PA; parent=FBgn0003719,FBtr0084691; dbxref=GB_protein:AAF56329.1,FlyBase:FBpp0084070,FlyBase_Annotation_IDs:CG6868-PA,GB_protein:AAF56329.2,REFSEQ:NP_524487,GB_protein:AAF56329,FlyMine:FBpp0084070,modMine:FBpp0084070; MD5=14eb76ccfd62c80f78390a3357c36734; length=1067; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta] type=protein; loc=3R:join(24749796..24749993,24750056..24750117,24750263..24750607,24750662..24751482,24751534..24751795,24751849..24752417,24752474..24753420); ID=FBpp0084070; name=tld-PA; parent=FBgn0003719,FBtr0084691; dbxref=GB_protein:AAF56329.1,FlyBase:FBpp0084070,FlyBase_Annotation_IDs:CG6868-PA,GB_protein:AAF56329.2,REFSEQ:NP_524487,GB_protein:AAF56329,FlyMine:FBpp0084070,modMine:FBpp0084070; MD5=14eb76ccfd62c80f78390a3357c36734; length=1067; release=r6.07; species=Dmel; [fly-08202015-contam.fasta] FBpp0084070 type=protein; loc=3R:join(24749796..24749993,24750056..24750117,24750263..24750607,24750662..24751482,24751534..24751795,24751849..24752417,24752474..24753420); ID=FBpp0084070; name=tld-PA; parent=FBgn0003719,FBtr0084691; dbxref=GB_protein:AAF56329.1,FlyBase:FBpp0084070,FlyBase_Annotation_IDs:CG6868-PA,GB_protein:AAF56329.2,REFSEQ:NP_524487,GB_protein:AAF56329,FlyMine:FBpp0084070,modMine:FBpp0084070; MD5=14eb76ccfd62c80f78390a3357c36734; length=1067; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta] [fly-122215-dmel-6-09-contam.fasta] type=protein; loc=3R:join(24749796..24749993,24750056..24750117,24750263..24750607,24750662..24751482,24751534..24751795,24751849..24752417,24752474..24753420); ID=FBpp0084070; name=tld-PA; parent=FBgn0003719,FBtr0084691; dbxref=GB_protein:AAF56329.1,FlyBase:FBpp0084070,FlyBase_Annotation_IDs:CG6868-PA,GB_protein:AAF56329.2,REFSEQ:NP_524487,GB_protein:AAF56329,UniProt/Swiss-Prot:P25723,FlyMine:FBpp0084070,modMine:FBpp0084070; MD5=14eb76ccfd62c80f78390a3357c36734; length=1067; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
Organism:	Drosophila melanogaster
Length:	1067 amino acids
Gene Ontology:
Cellular Component:	extracellular region [NAS]
Biological Process:	torso signaling pathway [IGI] positive regulation of BMP signaling pathway [TAS] terminal region determination [IGI] zygotic specification of dorsal/ventral axis [NAS] embryonic pattern specification [TAS] proteolysis [IEA][NAS] amnioserosa formation [NAS] imaginal disc-derived wing vein morphogenesis [IMP] protein maturation by peptide bond cleavage [IDA] regulation of transforming growth factor beta receptor signaling pathway [TAS] maternal specification of dorsal/ventral axis, oocyte, soma encoded [IMP]
Molecular Function:	zinc ion binding [IEA] calcium ion binding [IEA] metalloendopeptidase activity [ISS][NAS] specific transcriptional repressor activity [IMP]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKGMRLMPMK MKAKLVVLSV GALWMMMFFL VDYAEGRRLS QLPESECDFD FKEQPEDFFG  60
   61 ILDSSLVPPK EPKDDIYQLK TTRQHSGRRR KQSHKSQNKA ALRLPPPFLW TDDAVDVLQH 120
  121 SHSPTLNGQP IQRRRRAVTV RKERTWDYGV IPYEIDTIFS GAHKALFKQA MRHWENFTCI 180
  181 KFVERDPNLH ANYIYFTVKN CGCCSFLGKN GNGRQPISIG RNCEKFGIII HELGHTIGFH 240
  241 HEHARGDRDK HIVINKGNIM RGQEYNFDVL SPEEVDLPLL PYDLNSIMHY AKNSFSKSPY 300
  301 LDTITPIGIP PGTHLELGQR KRLSRGDIVQ ANLLYKCASC GRTYQQNSGH IVSPHFIYSG 360
  361 NGVLSEFEGS GDAGEDPSAE SEFDASLTNC EWRITATNGE KVILHLQQLH LMSSDDCTQD 420
  421 YLEIRDGYWH KSPLVRRICG NVSGEVITTQ TSRMLLNYVN RNAAKGYRGF KARFEVVCGG 480
  481 DLKLTKDQSI DSPNYPMDYM PDKECVWRIT APDNHQVALK FQSFELEKHD GCAYDFVEIR 540
  541 DGNHSDSRLI GRFCGDKLPP NIKTRSNQMY IRFVSDSSVQ KLGFSAALML DVDECKFTDH 600
  601 GCQHLCINTL GSYQCGCRAG YELQANGKTC EDACGGVVDA TKSNGSLYSP SYPDVYPNSK 660
  661 QCVWEVVAPP NHAVFLNFSH FDLEGTRFHY TKCNYDYLII YSKMRDNRLK KIGIYCGHEL 720
  721 PPVVNSEQSI LRLEFYSDRT VQRSGFVAKF VIDVDECSMN NGGCQHRCRN TFGSYQCSCR 780
  781 NGYTLAENGH NCTETRCKFE ITTSYGVLQS PNYPEDYPRN IYCYWHFQTV LGHRIQLTFH 840
  841 DFEVESHQEC IYDYVAIYDG RSENSSTLGI YCGGREPYAV IASTNEMFMV LATDAGLQRK 900
  901 GFKATFVSEC GGYLRATNHS QTFYSHPRYG SRPYKRNMYC DWRIQADPES SVKIRFLHFE 960
  961 IEYSERCDYD YLEITEEGYS MNTIHGRFCG KHKPPIIISN SDTLLLRFQT DESNSLRGFA1020
 1021 ISFMAVDPPE DSVGEDFDAV TPFPGYLKSM YSSETGSDHL LPPSRLI

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein Overview: tld-PA

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: