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Protein Overview: PUR9_ECOLI

General Information:
Name(s) found: PUR9_ECOLI [Swiss-Prot]
Description(s) found:
Found 12 descriptions.
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  • Bifunctional purine biosynthesis protein purH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC 2.1.2.3) (AICAR transformylase); IMP cyclohydrolase (EC 3.5.4.10) (Inosinicase) (IMP synthetase) (ATIC)] - Escherichia coli [Swiss-Prot]
    • Organism: Escherichia coli
    Length: 529 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQQRRPVRRA LLSVSDKAGI VEFAQALSAR GVELLSTGGT ARLLAEKGLP VTEVSDYTGF  60
   61 PEMMDGRVKT LHPKVHGGIL GRRGQDDAIM EEHQIQPIDM VVVNLYPFAQ TVAREGCSLE 120
  121 DAVENIDIGG PTMVRSAAKN HKDVAIVVKS SDYDAIIKEM DDNEGSLTLA TRFDLAIKAF 180
  181 EHTAAYDSMI ANYFGSMVPA YHGESKEAAG RFPRTLNLNF IKKLDMRYGE NSHQQAAFYI 240
  241 EENVKEASVA TATQVQGKAL SYNNIADTDA ALECVKEFAE PACVIVKHAN PCGVAIGNSI 300
  301 LDAYDRAYKT DPTSAFGGII AFNRELDAET AQAIISRQFV EVIIAPSASE EALKITAAKQ 360
  361 NVRVLTCGQW GERVPGLDFK RVNGGLLVQD RDLGMVGAEE LRVVTKRQPS EQELRDALFC 420
  421 WKVAKFVKSN AIVYAKNNMT IGIGAGQMSR VYSAKIAGIK AADEGLEVKG SSMASDAFFP 480
  481 FRDGIDAAAA AGVTCVIQPG GSIRDDEVIA AADEHGIAML FTDMRHFRH

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..529] PSI-BLAST 163.0 Crystal Structure of Human ATIC in complex with folate-based inhibitor BW1540U88UD

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • IMP cyclohydrolase activity
    		•  2.44338227123463 bayes_pls_golite062009
  • phosphoribosylaminoimidazolecarboxamide formyltransferase activity
    		•  2.17104645465987 bayes_pls_golite062009
  • hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
    		•  1.79965948308471 bayes_pls_golite062009
  • catalytic activity
    		•  1.70756445127105 bayes_pls_golite062009
  • hydroxymethyl-, formyl- and related transferase activity
    		•  1.51378035087272 bayes_pls_golite062009
  • glycine hydroxymethyltransferase activity
    		•  1.19388272840449 bayes_pls_golite062009
  • deaminase activity
    		•  1.16510523659661 bayes_pls_golite062009
  • hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
    		•  1.03324558866637 bayes_pls_golite062009
  • cytidine deaminase activity
    		•  0.870445440530128 bayes_pls_golite062009
  • binding
    		•  0.778641298104072 bayes_pls_golite062009
  • protein binding
    		•  0.095488575269861 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.82

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle