YRC Public Data Repository - Protein Structure Prediction

Protein:	PUR9_ECOLI
Organism:	Escherichia coli
Length:	529 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PUR9_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|91187739, gi\|... - gi\|91228713\|ref\|ZP_01262626.1\| bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferas...	814.0	[0..1]	[529..1]
PUR9_SALTY - Bifunctional purine biosynthesis protein PurH OS=Salmonella typhimurium GN=purH PE=3 SV=2 lcl\|NC_016856.1_... - [gene=purH] [protein=bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cycl... PUR9_SALTY - Bifunctional purine biosynthesis protein purH OS=Salmonella typhimurium GN=purH PE=3 SV=2 PUR9_SALTY - Bifunctional purine biosynthesis protein PurH OS=Salmonella typhimurium (strain LT2 / SGSC1412 / ATC...	814.0	[0..1]	[529..1]
PUR9_SALPA - Bifunctional purine biosynthesis protein PurH OS=Salmonella paratyphi A (strain ATCC 9150 / SARB42) ... PUR9_SALPA - Bifunctional purine biosynthesis protein PurH OS=Salmonella paratyphi A GN=purH PE=3 SV=1 PUR9_SALPK - Bifunctional purine biosynthesis protein PurH OS=Salmonella paratyphi A (strain AKU_12601) GN=purH P...	813.0	[0..1]	[529..1]
PUR9_VIBVU - Bifunctional purine biosynthesis protein PurH OS=Vibrio vulnificus (strain CMCP6) GN=purH PE=3 SV=1 PUR9_VIBVU - Bifunctional purine biosynthesis protein PurH OS=Vibrio vulnificus GN=purH PE=3 SV=1 PUR9_VIBVY - Bifunctional purine biosynthesis protein PurH OS=Vibrio vulnificus (strain YJ016) GN=purH PE=3 SV=1	812.0	[0..1]	[529..1]
PUR9_ECO57 - Bifunctional purine biosynthesis protein PurH OS=Escherichia coli O157:H7 GN=purH PE=3 SV=1 gi\|208742066, gi... - gi\|208821943\|ref\|ZP_03262263.1\| phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cycloh... gi\|208733466, gi... - gi\|208812189\|ref\|ZP_03253518.1\| phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cycloh... gi\|208807249, gi... - gi\|208807249\|ref\|ZP_03249586.1\| phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cycloh... gi\|195939632 - gi\|195939632\|ref\|ZP_03085014.1\| bifunctional phosphoribosylaminoimidazolecarboxamide formyltransfera... gi\|217320962, gi... - gi\|217324741\|ref\|ZP_03440825.1\| phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cycloh... PUR9_ECO5E - Bifunctional purine biosynthesis protein PurH OS=Escherichia coli O157:H7 (strain EC4115 / EHEC) GN=... gi\|254796004, gi... - gi\|254796004\|ref\|YP_003080841.1\| bifunctional phosphoribosylaminoimidazolecarboxamide formyltransfer... gi\|189359761, gi... - gi\|189359761\|gb\|EDU78180.1\| phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydro... gi\|188014025, gi... - gi\|188014025\|gb\|EDU52147.1\| phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydro... gi\|12518938, gi\|... - gi\|15804597\|ref\|NP_290638.1\| bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/... gi\|189379197, gi... - gi\|189379197\|gb\|EDU97613.1\| phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydro... gi\|25286233, gi\|... - pir\|\|G86092 hypothetical protein purH [imported] - Escherichia coli (strain O157:H7, substrain EDL9... gi\|189370179, gi... - gi\|189370179\|gb\|EDU88595.1\| phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydro... gi\|168780392, gi... - gi\|189001652\|gb\|EDU70638.1\| phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydro... gi\|15834183, gi\|... - gi\|15834183\|ref\|NP_312956.1\| bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/... gi\|168777380, gi... - gi\|187767346\|gb\|EDU31190.1\| phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydro...	812.0	[0..1]	[529..1]
PUR9_ECOUT - Bifunctional purine biosynthesis protein PurH OS=Escherichia coli (strain UTI89 / UPEC) GN=purH PE=3... PUR9_ECOK1 - Bifunctional purine biosynthesis protein PurH OS=Escherichia coli O1:K1 / APEC GN=purH PE=3 SV=1 PUR9_ECO45 - Bifunctional purine biosynthesis protein PurH OS=Escherichia coli O45:K1 (strain S88 / ExPEC) GN=pur... gi\|237702773, gi... - gi\|237702773\|ref\|ZP_04533254.1\| bifunctional purine biosynthesis protein purH [Escherichia sp. 3_2_5...	812.0	[0..1]	[529..1]
PUR9_VIBF1 - Bifunctional purine biosynthesis protein PurH OS=Vibrio fischeri (strain ATCC 700601 / ES114) GN=pur...	812.0	[0..1]	[529..1]
PUR9_YERPB - Bifunctional purine biosynthesis protein PurH OS=Yersinia pseudotuberculosis serotype IB (strain PB1... PUR9_YERPS - Bifunctional purine biosynthesis protein PurH OS=Yersinia pseudotuberculosis GN=purH PE=3 SV=1 PUR9_YERPY - Bifunctional purine biosynthesis protein PurH OS=Yersinia pseudotuberculosis serotype O:3 (strain YP... PUR9_YERPS - Bifunctional purine biosynthesis protein PurH OS=Yersinia pseudotuberculosis serotype I (strain IP32...	812.0	[0..1]	[529..1]
PUR9_ECOL5 - Bifunctional purine biosynthesis protein PurH OS=Escherichia coli O6:K15:H31 (strain 536 / UPEC) GN=...	812.0	[0..1]	[529..1]
PUR9_SHIFL - Bifunctional purine biosynthesis protein PurH OS=Shigella flexneri GN=purH PE=3 SV=1 gi\|193067938, gi... - gi\|75238547\|ref\|ZP_00722536.1\| COG0138: AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclo... PUR9_ECOSE - Bifunctional purine biosynthesis protein PurH OS=Escherichia coli (strain SE11) GN=purH PE=3 SV=1 gi\|75255503, gi\|... - gi\|75255503\|ref\|ZP_00727302.1\| COG0138: AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclo... PUR9_ECO8A - Bifunctional purine biosynthesis protein PurH OS=Escherichia coli O8 (strain IAI1) GN=purH PE=3 SV=1 PUR9_SHIB3 - Bifunctional purine biosynthesis protein PurH OS=Shigella boydii serotype 18 (strain CDC 3083-94 / B... gi\|75228123, gi\|... - gi\|75228123\|ref\|ZP_00714792.1\| COG0138: AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclo... PUR9_SHIF8 - Bifunctional purine biosynthesis protein PurH OS=Shigella flexneri serotype 5b (strain 8401) GN=purH... PUR9_SHISS - Bifunctional purine biosynthesis protein PurH OS=Shigella sonnei (strain Ss046) GN=purH PE=3 SV=1 PUR9_SHIBS - Bifunctional purine biosynthesis protein PurH OS=Shigella boydii serotype 4 (strain Sb227) GN=purH P... gi\|24115290, gi\|... - gi\|24115290\|ref\|NP_709800.1\| bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/... gi\|30042972, gi\|... - gi\|30064712\|ref\|NP_838883.1\| bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/...	811.0	[0..1]	[529..1]

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Predicted Domain #1

Region A:
Residues: [1-529]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQQRRPVRRA LLSVSDKAGI VEFAQALSAR GVELLSTGGT ARLLAEKGLP VTEVSDYTGF  60
   61 PEMMDGRVKT LHPKVHGGIL GRRGQDDAIM EEHQIQPIDM VVVNLYPFAQ TVAREGCSLE 120
  121 DAVENIDIGG PTMVRSAAKN HKDVAIVVKS SDYDAIIKEM DDNEGSLTLA TRFDLAIKAF 180
  181 EHTAAYDSMI ANYFGSMVPA YHGESKEAAG RFPRTLNLNF IKKLDMRYGE NSHQQAAFYI 240
  241 EENVKEASVA TATQVQGKAL SYNNIADTDA ALECVKEFAE PACVIVKHAN PCGVAIGNSI 300
  301 LDAYDRAYKT DPTSAFGGII AFNRELDAET AQAIISRQFV EVIIAPSASE EALKITAAKQ 360
  361 NVRVLTCGQW GERVPGLDFK RVNGGLLVQD RDLGMVGAEE LRVVTKRQPS EQELRDALFC 420
  421 WKVAKFVKSN AIVYAKNNMT IGIGAGQMSR VYSAKIAGIK AADEGLEVKG SSMASDAFFP 480
  481 FRDGIDAAAA AGVTCVIQPG GSIRDDEVIA AADEHGIAML FTDMRHFRH

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	163.0
Match:	1p4rA
Description:	Crystal Structure of Human ATIC in complex with folate-based inhibitor BW1540U88UD
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
IMP cyclohydrolase activity	2.44338227123463	bayes_pls_golite062009
phosphoribosylaminoimidazolecarboxamide formyltransferase activity	2.17104645465987	bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines	1.79965948308471	bayes_pls_golite062009
catalytic activity	1.70756445127105	bayes_pls_golite062009
hydroxymethyl-, formyl- and related transferase activity	1.51378035087272	bayes_pls_golite062009
glycine hydroxymethyltransferase activity	1.19388272840449	bayes_pls_golite062009
deaminase activity	1.16510523659661	bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	1.03324558866637	bayes_pls_golite062009
cytidine deaminase activity	0.870445440530128	bayes_pls_golite062009
binding	0.778641298104072	bayes_pls_golite062009
protein binding	0.095488575269861	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: