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Protein Overview: PROF1_DICDI

General Information:
Name(s) found: PROF1_DICDI [Swiss-Prot]
Description(s) found:
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  • gi|7324|emb|CAA43781.1| profilin I [Dictyostelium discoideum] [NCBI NR]
  • pir||FADO1 profilin I - slime mold (Dictyostelium discoideum) [NCBI NR]
  • gi|60465761|gb|EAL63837.1| profilin I [Dictyostelium discoideum] [NCBI NR]
  • gi|130943|sp|P26199.1|PROF1_DICDI RecName: Full=Profilin-1; AltName: Full=Profilin I [NCBI NR]
  • Profilin-1 OS=Dictyostelium discoideum GN=proA PE=2 SV=1 [Swiss-Prot]
  • (P26199) Profilin I [Swiss-Prot]
  • Profilin Igi|71647|pir||FADO1 profilin I - slime mold (Dictyostelium discoideum)gi|7324|emb|CAA43781.1| profilin I [Dictyostelium discoideum] [nrdb_11152004_Chlamydomonas]
  • |Protein| gene: proA on chromosome: 4 position 5397605 to 5398227 [dicty_predictions_protein.fasta]
  • Profilin-1 (Profilin I) [nr-271106-contam.fasta]
  • profilin I [Dictyostelium discoideum] [nr-271106-contam.fasta]
    • Organism: Dictyostelium discoideum
    Length: 126 amino acids

    Gene Ontology:
    Cellular Component: actin cytoskeleton [TAS]
    Biological Process: sequestering of actin monomers [TAS]
    negative regulation of actin filament polymerization [IDA][IMP]
    cellular component movement [IMP]
    actin nucleation [ISS]
    cytokinesis [IMP]
    pinocytosis [TAS]
    sexual reproduction [IEP]
    sorocarp development [IMP]
    negative regulation of phagocytosis [TAS]
    Molecular Function: actin binding [TAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSWQQYVDEQ LTGAGLSQGA ILGANDGGVW AKSSGINITK PEGDGIAALF KNPAEVFAKG  60
   61 ALIGGVKYMG IKGDPQSIYG KKGATGCVLV RTGQAIIVGI YDDKVQPGSA ALIVEKLGDY 120
  121 LRDNGY

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..126] PSI-BLAST 48.0 Profilin (actin-binding protein)

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • actin binding
    		•  7.981958446142 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  6.51470611165788 bayes_pls_golite062009
  • actin monomer binding
    		•  3.80837480536839 bayes_pls_golite062009
  • binding
    		•  3.26636517628678 bayes_pls_golite062009
  • phosphatidylinositol-4,5-bisphosphate binding
    		•  3.24248939295046 bayes_pls_golite062009
  • protein binding
    		•  2.14534188091242 bayes_pls_golite062009
  • phosphoinositide binding
    		•  1.69872978885701 bayes_pls_golite062009
  • phospholipid binding
    		•  1.52027694872856 bayes_pls_golite062009
  • transporter activity
    		•  1.434681455285 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  1.23300160340736 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  0.490905558612378 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.96

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle