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Protein Overview: KMT2C_MOUSE

General Information:
Name(s) found: KMT2C_MOUSE [Swiss-Prot]
Description(s) found:
Found 11 descriptions.
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  • Histone-lysine N-methyltransferase 2C OS=Mus musculus GN=Kmt2c PE=1 SV=2 [Swiss-Prot]
    • Organism: Mus musculus
    Length: 4903 amino acids

    Gene Ontology:
    Cellular Component: nucleus [UNKNOWN]
    histone methyltransferase complex [UNKNOWN]
    Biological Process: chromatin modification [IEA]
    intracellular signaling pathway [IEA]
    transcription [IEA]
    histone methylation [IDA]
    regulation of transcription, DNA-dependent [IEA]
    regulation of transcription [IEA]
    Molecular Function: histone methyltransferase activity (H3-K4 specific) [UNKNOWN]
    DNA binding [IEA]
    zinc ion binding [IEA]
    protein binding [IEA]
    metal ion binding [IEA]
    histone-lysine N-methyltransferase activity [IEA]
    methyltransferase activity [IEA]
    transferase activity [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSEEDRSAE QQQPPPAPPE EPGAPAPSPA AADKRPRGRP RKDGASPFQR ARKKPRSRGK  60
   61 STVEDEDSMD GLETTETENI VETEIKEQSV EEDAETEVDS SKQPVSALQR SVSEESANSL 120
  121 VSVGVEAKIS EQLCAFCYCG EKSSLGQGDL KQFRVTPGLT LPWKDQPSNK DIDDNSSGTC 180
  181 EKIQNYAPRK QRGQRKERPP QQSAVSCVSV STQTACEDQA GKLWDELSLV GLPDAIDVQA 240
  241 LFDSTGTCWA HHRCVEWSLG ICQMEEPLLV NVDKAVVSGS TERCAFCKHL GATIKCCEEK 300
  301 CTQMYHYPCA AGAGTFQDFS HFFLLCPEHI DQAPERSKED ANCAVCDSPG DLLDQFFCTT 360
  361 CGQHYHGMCL DIAVTPLKRA GWQCPECKVC QNCKQSGEDS KMLVCDTCDK GYHTFCLQPV 420
  421 MKSVPTNGWK CKNCRICIEC GTRSSTQWHH NCLICDTCYQ QQDNLCPFCG KCYHPELQKD 480
  481 MLHCNMCKRW VHLECDKPTD QELDSQLKED YICMYCKHLG AEIDPLHPGN EVEMPELPTD 540
  541 YASGMEIEGT EDEVVFLEQT VNKDVSDHQC RPGIVPDVQV YTEEPQKSNP LESPDTVGLI 600
  601 TSESSDNKMN PDLANEIAHE VDTEKTEMLS KGRHVCEEDQ NEDRMEVTEN IEVLPHQTIV 660
  661 PQEDLLLSED SEVASKELSP PKSAPETAAP EALLSPHSER SLSCKEPLLT ERVQEEMEQK 720
  721 ENSEFSTGCV DFEMTLAVDS CDKDSSCQGD KYVELPAEEE STFSSATDLN KADVSSSSTL 780
  781 CSDLPSCDML HGYPPAFNSA AGSIMPTTYI SVTPKIGMGK PAITKRKFSP GRPRSKQGAW 840
  841 SNHNTVSPPS WAPDTSEGRE IFKPRQLSGS AIWSIKVGRG SGFPGKRRPR GAGLSGRGGR 900
  901 GRSKLKSGIG AVVLPGVSAA DISSNKDEEE NSMHNTVVLF SSSDKFTLQQ DMCVVCGSFG 960
  961 QGAEGRLLAC SQCGQCYHPY CVSIKITKVV LSKGWRCLEC TVCEACGKAT DPGRLLLCDD1020
 1021 CDISYHTYCL DPPLQTVPKG GWKCKWCVWC RHCGATSAGL RCEWQNNYTQ CAPCASLSSC1080
 1081 PVCCRNYREE DLILQCRQCD RWMHAVCQNL NTEEEVENVA DIGFDCSMCR PYMPVSNVPS1140
 1141 SDCCDSSLVA QIVTKVKELD PPKTYTQDGV CLTESGMSQL QSLTVTAPRR KRTKPKLKLK1200
 1201 IINQNSVAVL QTPPDIQSEH SRDGEMDDSR EGELMDCDGK SESSPEREAG DDETKGIEGT1260
 1261 DAIKKRKRKP YRPGIGGFMV RQRSRTGQGK AKRSVVRKDS SGSISEQLPS RDDGWREQLP1320
 1321 DTLVDEPVSV AENTDKIKKR YRKRKNKLEE TFPAYLQEAF FGKDLLDTSR QNKLSVDNLS1380
 1381 EDAAQLSFKT GFLDPSSDPL LSSSSTSAKP GTQGTADDPL ADISEVLNTD DDILGIISDD1440
 1441 LAKSVDHSDI GPTTADASSL PQPGVSQSSR PLTEEQLDGI LSPELDKMVT DGAILGKLYK1500
 1501 IPELGGKDVE DLFTAVLSPA TTQPAPLPQP PPPPQLLPMH NQDVFSRMPL MNGLIGPSPH1560
 1561 LPHNSLPPGS GLGTFPAIAQ SPYTDVRDKS PAFNAIASDP NSSWAPTTPS MEGENDTLSN1620
 1621 AQRSTLKWEK EEALGEMATV APVLYTNINF PNLKEEFPDW TTRVKQIAKL WRKASSQERA1680
 1681 PYVQKARDNR AALRINKVQM SNDSMKRQQQ QDSIDPSSRI DSDLFKDPLK QRESEHEQEW1740
 1741 KFRQQMRQKS KQQAKIEATQ KLEQVKNEQQ QQQQQQQQQQ QQQLASQHLL VAPGSDTPSS1800
 1801 GAQSPLTPQA GNGNVSPAQT FHKDLFSKHL PGTPASTPSD GVFVKPQPPP PPSTPSRIPV1860
 1861 QESLSQSQNS QPPSPQMFSP GSSHSRPPSP VDPYAKMVGT PRPPPGGHSF PRRNSVTPVE1920
 1921 NCVPLSSVPR PIHMNETSAT RPSPARDLCA SSMTNSDPYA KPPDTPRPMM TDQFSKPFSL1980
 1981 PRSPVISEQS TKGPLTTGTS DHFTKPSPRT DAFQRQRLPD PYAGPSLTPA PLGNGPFKTP2040
 2041 LHPPPSQDPY GSVSQTSRRL SVDPYERPAL TPRPVDNFSH SQSNDPYSHP PLTPHPAMTE2100
 2101 SFTHASRAFP QPGTISRSAS QDPYSQPPGT PRPLIDSYSQ TSGTARSNPD PYSQPPGTPR2160
 2161 PNTIDPYSQQ PPTPRPSPQT DMFVSSVANQ RHTDPYTHHL GPPRPGISVP YSQPPAVPRP2220
 2221 RTSEGFTRPS SARPALMPNQ DPFLQAAQNR VPGLPGPLIR PPDTCSQTPR PPGPGRIDTF2280
 2281 THASSSAVRD PYDQPPVTPR PHSESFGTSQ VVHDLVDRPV PGSEGNFSTS SNLPVSSQGQ2340
 2341 QFSSVSQLPG PVPTSGGTDT QNTVNMSQAD TEKLRQRQKL REIILQQQQQ KKIASRQEKG2400
 2401 PQDTAVVPHP VPLPHWQPES INQAFTRPPP PYPGSTRSPV IPPLGPRYAV FPKDQRGPYP2460
 2461 PEVAGMGMRP HGFRFGFPGA GHGPMPSQDR FHVPQQIQGS GIPPHIRRPM SMEMPRPSNN2520
 2521 PPLNNPVGLP QHFPPQGLPV QQHNILGQAF IELRHRAPDG RSRLPFAASP SSVIESPSHP2580
 2581 RHGNFLPRPD FPGPRHTDPI RQPSQCLSNQ LPVHPNLEQV PPSQQEQGHP AHQSSIVMRP2640
 2641 LNHPLSGEFS EAPLSTSTPA ETSPDNLEIA GQSSAGLEEK LDSDDPSVKE LDVKDLEGVE2700
 2701 VKDLDDEDLE NLNLDTEDGK GDDLDTLDNL ETNDPNLDDL LRSGEFDIIA YTDPELDLGD2760
 2761 KKSMFNEELD LNVPIDDKLD NQCASVEPKT RDQGDKTMVL EDKDLPQRKS SVSSEIKTEA2820
 2821 LSPYSKEEIQ SEIKNHDDSR GDADTACSQA ASAQTNHSDR GKTALLTTDQ DMLEKRCNQE2880
 2881 NAGPVVSAIQ GSTPLPARDV MNSCDITGST PVLSSLLSNE KCDDSDIRPS GSSPPSLPIS2940
 2941 PSTHGSSLPP TLIVPPSPLL DNTVNSNVTV VPRINHAFSQ GVPVNPGFIQ GQSSVNHNLG3000
 3001 TGKPTNQTVP LTNQSSTMSG PQQLMIPQTL AQQNRERPLL LEEQPLLLQD LLDQERQEQQ3060
 3061 QQRQMQAMIR QRSEPFFPNI DFDAITDPIM KAKMVALKGI NKVMAQNSLG MPPMVMSRFP3120
 3121 FMGPSVAGTQ NNDGQTLVPQ AVAQDGSITH QISRPNPPNF GPGFVNDSQR KQYEEWLQET3180
 3181 QQLLQMQQKY LEEQIGAHRK SKKALSAKQR TAKKAGREFP EEDAEQLKHV TEQQSMVQKQ3240
 3241 LEQIRKQQKE HAELIEDYRI KQQQQQQQCA LAPPILMPGV QPQPPLVPGA TSLTMSQPNF3300
 3301 PMVPQQLQHQ QHTAVISGHT SPARMPSLPG WQSNSASAHL PLNPPRIQPP IAQLSLKTCT3360
 3361 PAPGTVSSAN PQNGPPPRVE FDDNNPFSES FQERERKERL REQQERQRVQ LMQEVDRQRA3420
 3421 LQQRMEMEQH CLMGAELANR TPVSQMPFYG SDRPCDFLQP PRPLQQSPQH QQQIGPVLQQ3480
 3481 QNVQQGSVNS PPNQTFMQTN EQRQVGPPSF VPDSPSASGG SPNFHSVKPG HGNLPGSSFQ3540
 3541 QSPLRPPFTP ILPGTSPVAN SNVPCGQDPA VTQGQNYSGS SQSLIQLYSD IIPEEKGKKK3600
 3601 RTRKKKKDDD AESGKAPSTP HSDCAAPLTP GLSETTSTPA VSSPSELPQQ RQQEPVEPVP3660
 3661 VPTPNVSAGQ PCIESENKLP NSEFIKETSN QQTHVNAEAD KPSVETPNKT EEIKLEKAET3720
 3721 QPSQEDTKVE EKTGNKIKDI VAGPVSSIQC PSHPVGTPTT KGDTGNELLK HLLKNKKASS3780
 3781 LLTQKPEGTL SSDESSTKDG KLIEKQSPAE GLQTLGAQMQ GGFGGGNSQL PKTDGASENK3840
 3841 KQRSKRTQRT GEKAAPRSKK RKKDEEEKQA MYSSSDSFTH LKQQNNLSNP PTPPASLPPT3900
 3901 PPPMACQKMA NGFATTEELA GKAGVLVSHE VARALGPKPF QLPFRPQDDL LARAIAQGPK3960
 3961 TVDVPASLPT PPHNNHEELR IQDHYGDRDT PDSFVPSSSP ESVVGVEVNK YPDLSLVKEE4020
 4021 PPEPVPSPII PILPSISGKN SESRRNDIKT EPGTLFFTSP FGSSPNGPRS GLISVAITLH4080
 4081 PTAAENISSV VAAFSDLLHV RIPNSYEVSN APDVPPMGLV SSHRVNPSLE YRQHLLLRGP4140
 4141 PPGSANPPRL ATSYRLKQPN VPFPPTSNGL SGYKDSSHGP AEGASLRPQW CCHCKVVILG4200
 4201 SGVRKSCKDL TFVNKGSREN TKRMEKDIVF CSNNCFILYS SAAQAKNSDN KESLPSLPQS4260
 4261 PMKEPSKAFH QYSNNISTLD VHCLPQFQEK VSPPASPPIS FPPAFEAAKV ESKPDELKVT4320
 4321 VKLKPRLRTV PVGLEDCRPL NKKWRGMKWK KWSIHIVIPK GTFKPPCEDE IDEFLKKLGT4380
 4381 CLKPDPVPKD CRKCCFCHEE GDGLTDGPAR LLNLDLDLWV HLNCALWSTE VYETQAGALI4440
 4441 NVELALRRGL QMKCVFCHKT GATSGCHRFR CTNIYHFTCA TKAQCMFFKD KTMLCPMHKP4500
 4501 KGIHEQQLSY FAVFRRVYVQ RDEVRQIASI VQRGERDHTF RVGSLIFHTI GQLLPQQMQA4560
 4561 FHSPKALFPV GYEASRLYWS TRYANRRCRY LCSIEEKDGR PVFVIRIVEQ GHEDLVLSDS4620
 4621 SPKDVWDKIL EPVACVRKKS EMLQLFPAYL KGEDLFGLTV SAVARIAESL PGVEACENYT4680
 4681 FRYGRNPLME LPLAVNPTGC ARSEPKMSAH VKRFVLRPHT LNSTSTSKSF QSTVTGELNA4740
 4741 PYSKQFVHSK SSQYRRMKTE WKSNVYLARS RIQGLGLYAA RDIEKHTMVI EYIGTIIRNE4800
 4801 VANRKEKLYE SQNRGVYMFR MDNDHVIDAT LTGGPARYIN HSCAPNCVAE VVTFERGHKI4860
 4861 IISSNRRIQK GEELCYDYKF DFEDDQHKIP CHCGAVNCRK WMN

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data



    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle