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Protein Overview: HPPK_ECOLI

General Information:
Name(s) found: HPPK_ECOLI [Swiss-Prot]
Description(s) found:
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  • gi|88192871|pdb|2F65|A Chain A, Solution Structure Of Hppk In Complex With Inhibitor Analog Ampcpp [NCBI NR]
  • gi|88192870|pdb|2F63|A Chain A, Solution Structure Of Hppk In Complex With Inhibitor Analogs Ampcpp And Hp-1 [NCBI NR]
  • gi|56965938|pdb|1RB0|A Chain A, Crystal Structure Of A Binary Complex Of E. Coli Hppk With 6-Hydroxymethylpterin-Diphosphate At 1.35 Angstrom Resolution [NCBI NR]
  • gi|56965937|pdb|1RAO|A Chain A, Crystal Structure Of A Ternary Complex Of E. Coli Hppk With Amp And 6-Hydroxymethylpterin-Diphosphate At 1.56 Angstrom Resolution [NCBI NR]
  • gi|5542271|pdb|1HKA| Chain , 6-Hydroxymethyl-7,8-Dihydropterin Pyrophosphokinase [NCBI NR]
  • gi|34810364|pdb|1Q0N|A Chain A, Crystal Structure Of A Ternary Complex Of 6-Hydroxymethyl-7, 8-Dihydropterin Pyrophosphokinase From E. Coli With Mgampcpp And 6-Hydroxymethyl-7,8-Dihydropterin At 1.25 Angstrom Resolution [NCBI NR]
  • gi|30749236|pdb|1F9Y|A Chain A, Crystal Structure Of The Ternary Complex Of E. Coli Hppk With Mgampcpp And Oxidation Products Of 6-Hydroxymethyl-7, 8-Dihydropterin [NCBI NR]
  • gi|16974796|pdb|1EQ0|A Chain A, Solution Structure Of 6-Hydroxymethyl-7,8-Dihydropterin Pyrophosphokinase Complexed With Mgamppcp [NCBI NR]
  • gi|157831342|pdb|1HKA|A Chain A, 6-Hydroxymethyl-7,8-Dihydropterin Pyrophosphokinase [NCBI NR]
  • gi|14278699|pdb|1EQM|A Chain A, Crystal Structure Of Binary Complex Of 6-Hydroxymethyl-7,8- Dihydropterin Pyrophosphokinase With Adenosine-5'- Diphosphate [NCBI NR]
  • gi|14278246|pdb|1EX8|A Chain A, Crystal Structure Of 6-Hydroxymethyl-7,8-Dihydropterin Pyrophosphokinase Complexed With Hp4a, The Two-Substrate- Mimicking Inhibitor [NCBI NR]
  • gi|10120863|pdb|1DY3|A Chain A, Ternary Complex Of 7,8-Dihydro-6- Hydroxymethylpterinpyrophosphokinase From Escherichia Coli With Atp And A Substrate Analogue. [NCBI NR]
  • (P26281) 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase (EC 2.7.6.3) (7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase) (HPPK) (6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase) (PPPK) [Swiss-Prot]
  • Chain A, Crystal Structure Of A Ternary Complex Of 6-Hydroxymethyl-7, 8-Dihydropterin Pyrophosphokinase From E. Coli With Mgampcpp And 6-Hydroxymethyl-7,8-Dihydropterin At 1.25 Angstrom Resolutiongi|30749236|pdb|1F9Y|A Chain A, Crystal Structure Of The T [nrdb_11152004_Chlamydomonas]
  • Chain A, Crystal Structure Of The Ternary Complex Of E. Coli Hppk With Mgampcpp And 6-Hydroxymethylpterin [nr-271106-contam.fasta]
  • Chain A, Crystal Structure Of Binary Complex Of 6-Hydroxymethyl-7,8- Dihydropterin Pyrophosphokinase With Adenosine-5'- Diphosphate [nr-271106-contam.fasta]
  • Chain A, Ternary Complex Of 7,8-Dihydro-6-Hydroxymethylpterinpyrophosphokinase From Escherichia Coli With Atp And A Substrate Analogue. [nr-271106-contam.fasta]
  • Chain A, Solution Structure Of Hppk In Complex With Inhibitor Analog Ampcpp [nr-271106-contam.fasta]
  • Chain A, Solution Structure Of Hppk In Complex With Inhibitor Analogs Ampcpp And Hp-1 [nr-271106-contam.fasta]
  • Chain A, Crystal Structure Of A Ternary Complex Of E. Coli Hppk With Amp And 6-Hydroxymethylpterin-Diphosphate At 1.56 Angstrom Resolution [nr-271106-contam.fasta]
  • Chain A, Crystal Structure Of A Ternary Complex Of 6-Hydroxymethyl-7, 8-Dihydropterin Pyrophosphokinase From E. Coli With Mgampcpp And 6-Hydroxymethyl-7,8-Dihydropterin At 1.25 Angstrom Resolution [nr-271106-contam.fasta]
  • Chain A, Crystal Structure Of 6-Hydroxymethyl-7,8-Dihydropterin Pyrophosphokinase Complexed With Hp4a, The Two-Substrate- Mimicking Inhibitor [nr-271106-contam.fasta]
  • Chain A, Solution Structure Of 6-Hydroxymethyl-7,8-Dihydropterin Pyrophosphokinase Complexed With Mgamppcp [nr-271106-contam.fasta]
  • Chain A, Crystal Structure Of A Binary Complex Of E. Coli Hppk With 6-Hydroxymethylpterin-Diphosphate At 1.35 Angstrom Resolution [nr-271106-contam.fasta]
  • Chain , 6-Hydroxymethyl-7,8-Dihydropterin Pyrophosphokinase [nr-271106-contam.fasta]
    • Organism: Escherichia coli
    Length: 158 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TVAYIAIGSN LASPLEQVNA ALKALGDIPE SHILTVSSFY RTPPLGPQDQ PDYLNAAVAL  60
   61 ETSLAPEELL NHTQRIELQQ GRVRKAERWG PRTLDLDIML FGNEVINTER LTVPHYDMKN 120
  121 RGFMLWPLFE IAPELVFPDG EMLRQILHTR AFDKLNKW

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Noble WS, et al. (2009) Manuscript in preparation. HPPK_ECOLI gi|134105085, gi... gi|189095939, gi...

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..158] PSI-BLAST 55.0 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, HPPK

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity
    		•  5.95418117400583 bayes_pls_golite062009
  • diphosphotransferase activity
    		•  4.79017391246148 bayes_pls_golite062009
  • catalytic activity
    		•  2.44295736158702 bayes_pls_golite062009
  • transferase activity
    		•  1.5312510694044 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  1.34283740138285 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle