YRC Public Data Repository - Protein Structure Prediction

Protein:	HPPK_ECOLI
Organism:	Escherichia coli
Length:	158 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

[What does the above image mean?]

[Show Ginzu Version Information]

Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for HPPK_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|28807503 - gi\|28807503\|dbj\|BAC60768.1\| 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase [Vi... gi\|28899279, gi\|... - gi\|28899279\|ref\|NP_798884.1\| 2-amino-4-hydroxy-6-hydroxymethyldihydropteridin e pyrophosphokinase [V... gi\|153840011, gi... - gi\|153840011\|ref\|ZP_01992678.1\| 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase ...	219.0	[0..2]	[158..3]
gi\|37524868, gi\|... - gi\|37524868\|ref\|NP_928212.1\| 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokina se [Photorhabdus lumi...	217.0	[0..2]	[158..3]
gi\|116183347, gi... - gi\|75853807\|ref\|ZP_00761565.1\| COG0801: 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase [Vibrio ...	217.0	[0..2]	[158..3]
gi\|91187824, gi\|... - gi\|91228641\|ref\|ZP_01262558.1\| 2-amino-4-hydroxy-6-hydroxymethyldihydropteridin e pyrophosphokinase ...	216.0	[0..2]	[158..3]
gi\|229695404, gi... - gi\|229839038\|ref\|ZP_04459197.1\| 2-amino-4-hydroxy-6-hydroxymethyldihyropteridine pyrophosphokinase [... gi\|229896517, gi... - gi\|229896517\|ref\|ZP_04511685.1\| 2-amino-4-hydroxy-6-hydroxymethyldihyropteridine pyrophosphokinase [... gi\|229899603, gi... - gi\|229899603\|ref\|ZP_04514744.1\| 2-amino-4-hydroxy-6-hydroxymethyldihyropteridine pyrophosphokinase [... gi\|149289194, gi... - gi\|153997557\|ref\|ZP_02022657.1\| 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase... gi\|145600215, gi... - gi\|145600215\|ref\|YP_001164291.1\| 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinas... gi\|165922361, gi... - gi\|165925749\|ref\|ZP_02221581.1\| 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase ... gi\|165936683, gi... - gi\|165936683\|ref\|ZP_02225250.1\| 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase ... gi\|108780805, gi... - gi\|108808892\|ref\|YP_652808.1\| 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase [... gi\|25288337 - pir\|\|AB0413 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase (EC 2.7.6.3) [imported... gi\|77634835, gi\|... - gi\|77634835\|ref\|ZP_00796928.1\| COG0801: 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase [Yersini... gi\|153947633, gi... - gi\|77631709\|ref\|ZP_00794295.1\| COG0801: 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase [Yersini... gi\|45440144, gi\|... - gi\|45440144\|ref\|NP_991683.1\| 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase [Y... gi\|21957514, gi\|... - gi\|22124700\|ref\|NP_668123.1\| 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase [Y... gi\|218930417, gi... - gi\|218930417\|ref\|YP_002348292.1\| 2-amino-4-hydroxy-6-hydroxymethyldihydropteridin e pyrophosphokinas... gi\|229681788, gi... - gi\|229901063\|ref\|ZP_04516186.1\| 2-amino-4-hydroxy-6-hydroxymethyldihyropteridine pyrophosphokinase [... gi\|51588363, gi\|... - gi\|51595081\|ref\|YP_069272.1\| 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokina se, PPPK [Yersinia ps... gi\|165990950, gi... - gi\|166010043\|ref\|ZP_02230941.1\| 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase ... gi\|166214089, gi... - gi\|166214089\|ref\|ZP_02240124.1\| 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase ... Q66EG2\|Q66EG2_YERPS - 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokina se, PPPK precursor - Yersinia pseudotuberculosis gi\|167399571, gi... - gi\|167399571\|ref\|ZP_02305095.1\| 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase ... gi\|167420709, gi... - gi\|167420709\|ref\|ZP_02312462.1\| 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase ... gi\|167423485, gi... - gi\|167423485\|ref\|ZP_02315238.1\| 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase ... gi\|167469894 - gi\|167469894\|ref\|ZP_02334598.1\| 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase ... gi\|170025686, gi... - gi\|170025686\|ref\|YP_001722191.1\| 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase... gi\|186894091, gi... - gi\|186894091\|ref\|YP_001871203.1\| 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase...	215.0	[0..2]	[158..3]
gi\|59712775, gi\|... - gi\|59712775\|ref\|YP_205551.1\| 2-amino-4-hydroxy-6-hydroxymethyldihyropteridine pyrophosphokinase [Vib...	215.0	[0..3]	[158..4]
gi\|82775534, gi\|... - gi\|82775534\|ref\|YP_401881.1\| 2-amino-4-hydroxy-6-hydroxymethyldihyropteridine pyrophosphokinase [Shi...	213.0	[0..1]	[158..2]
gi\|238797184, gi... - gi\|77962796\|ref\|ZP_00826612.1\| COG0801: 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase [Yersini...	213.0	[0..2]	[158..3]
gi\|85833913, gi\|... - gi\|86148288\|ref\|ZP_01066583.1\| 2-amino-4-hydroxy-6-hydroxymethyldihydropteridin epyrophosphokinase [...	212.0	[0..2]	[158..3]
gi\|75240267, gi\|... - gi\|75240267\|ref\|ZP_00724214.1\| COG0801: 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase [Escheri... gi\|110640363, gi... - gi\|110640363\|ref\|YP_668091.1\| 2-amino-4-hydroxy-6-hydroxymethyldihyropteridine pyrophosphokinase [Es... gi\|215263374, gi... - gi\|215485302\|ref\|YP_002327733.1\| 2-amino-4-hydroxy-6-hydroxymethyldihyropteridine pyrophosphokinase ...	212.0	[0..1]	[158..2]

Back

Predicted Domain #1

Region A:
Residues: [1-158]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TVAYIAIGSN LASPLEQVNA ALKALGDIPE SHILTVSSFY RTPPLGPQDQ PDYLNAAVAL  60
   61 ETSLAPEELL NHTQRIELQQ GRVRKAERWG PRTLDLDIML FGNEVINTER LTVPHYDMKN 120
  121 RGFMLWPLFE IAPELVFPDG EMLRQILHTR AFDKLNKW

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	55.0
Match:	1dy3A
Description:	6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, HPPK
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity	5.95418117400583	bayes_pls_golite062009
diphosphotransferase activity	4.79017391246148	bayes_pls_golite062009
catalytic activity	2.44295736158702	bayes_pls_golite062009
transferase activity	1.5312510694044	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	1.34283740138285	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: