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Protein Overview: Dsp1-PE

General Information:
Name(s) found: Dsp1-PE / FBpp0089258 [FlyBase]
Description(s) found:
Found 22 descriptions.
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  • The gene Dorsal switch protein 1 is referred to in FlyBase by the symbol Dmel\Dsp1 (CG12223, FBgn0011764). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:16227645..16232927. It has the cytological map location 14B14-14B15. It is reported to have molecular function</span>: single-stranded DNA binding; transcription corepressor activity. There is experimental evidence that it is involved in the biological process</span>: negative regulation of antimicrobial humoral response; leg disc development. 11 alleles are reported. The phenotypes of these alleles are annotated with 14 unique terms, many of which group under: adult segment; organ system; peripheral nervous system; abdominal ventral denticle belt; thoracic segment; nervous system; adult mesothoracic segment; integumentary plate; cuticle; adult abdominal segment; egg; abdominal 5 ventral denticle belt; multi-cell-component structure; external compound sense organ. It has 6 annotated transcripts and 6 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 393 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IC][IDA]
    Biological Process: negative regulation of transcription from RNA polymerase II promoter [IDA][IMP]
    chromatin remodeling [IMP]
    leg disc development [IMP]
    positive regulation of DNA binding [IDA]
    developmental process [IMP]
    segment specification [IMP]
    negative regulation of antimicrobial humoral response [IGI][IMP]
    Molecular Function: DNA binding [IDA]
    DNA bending activity [IDA]
    transcription factor binding [IPI]
    transcription repressor activity [IDA][IMP]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEHFHQIQQT IQHYQQQLAA QQQQQVQQQQ LQQHQVVVQQ NQQQAHQNSS NTTAGVGTQQ  60
   61 LFTYKMASSF PNPATTMAQV VATSNAAGTT GYDYRLNMAQ AAAAAAVPGS QWWYSAANQG 120
  121 QVDANTAAQL QHQQQQQQQQ QQQQQQQHQQ QQQMQQQQQQ QNVINSASPM SRVKADAKPR 180
  181 GRMTAYAYFV QTCREEHKKK HPDETVIFAE FSRKCAERWK TMVDKEKKRF HEMAEKDKQR 240
  241 YEAEMQNYVP PKGAVVGRGK KRKQIKDPNA PKRSLSAFFW FCNDERNKVK ALNPEFGVGD 300
  301 IAKELGRKWS DVDPEVKQKY ESMAERDKAR YEREMTEYKT SGKIAMSAPS MQASMQAQAQ 360
  361 KAALLAAAAQ QQHQQLEEQH DDDDGDGDDD ENQ

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..96] MSA 2.087995 View MSA. No confident structure predictions are available.
    2 View Details [97..172] deduced N/A No confident structure predictions are available.
    3 View Details [173..393] PSI-BLAST 34.0 No description for 2gzkA was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • binding
    		•  0.927928103499335 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.38664561645052 bayes_pls_golite062009
  • DNA binding
    		•  0.37554038880732 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle