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Protein Overview: DHFRP1, DHFR

General Information:
Name(s) found: DHFRP1 [HGNC (HUGO)]
DHFR [HGNC (HUGO)]
Description(s) found:
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  • gi|83753728|pdb|1YHO|A Chain A, Solution Structure Of Human Dihydrofolate Reductase Complexed With Trimethoprim And Nadph, 25 Structures [NCBI NR]
  • gi|60593617|pdb|1U72|A Chain A, Understanding The Role Of Leu22 Variants In Methotrexate Resistance: Comparison Of Wild-Type And Leu22arg Variant Mouse And Human Dihydrfolate Reductase Ternary Crystal Complexes With Methotrexate And Nadph [NCBI NR]
  • gi|47169010|pdb|1S3W|A Chain A, Structure Determination Of Tetrahydroquinazoline Antifoaltes In Complex With Human And Pneumocystis Carinii Dihydrofolate Reductase: Correlations Of Enzyme Selectivity And Stereochemistry [NCBI NR]
  • gi|47169009|pdb|1S3V|A Chain A, Structure Determination Of Tetrahydroquinazoline Antifolates In Complex With Human And Pneumocystis Carinii Dihydrofolate Reductase: Correlations Of Enzyme Selectivity And Stereochemistry [NCBI NR]
  • gi|47169008|pdb|1S3U|A Chain A, Structure Determination Of Tetrahydroquinazoline Antifolates In Complex With Human And Pneumocystis Carinii Dihydrofolate Reductase: Correlations Of Enzyme Selectivity And Stereochemistry [NCBI NR]
  • gi|40889307|pdb|1PDB|A Chain A, Analysis Of Three Crystal Structure Determinations Of A 5- Methyl-6-N-Methylanilino Pyridopyrimidine Antifolate Complex With Human Dihydrofolate Reductase [NCBI NR]
  • gi|40889306|pdb|1PD9|A Chain A, Analysis Of Three Crystal Structure Determinations Of A 5- Methyl-6-N-Methylanilino Pyridopyrimidine Antifolate Complex With Human Dihydrofolate Reductase [NCBI NR]
  • gi|40889305|pdb|1PD8|A Chain A, Analysis Of Three Crystal Structure Determinations Of A 5- Methyl-6-N-Methylanilino Pyridopyrimidine Antifolate Complex With Human Dihydrofolate Reductase [NCBI NR]
  • gi|3212582|pdb|1OHK| Chain , Human Dihydrofolate Reductase, Orthorhombic (P21 21 21) Crystal Form [NCBI NR]
  • gi|3212581|pdb|1OHJ| Chain , Human Dihydrofolate Reductase, Monoclinic (P21) Crystal Form [NCBI NR]
  • gi|2914338|pdb|1HFR| Chain , Comparison Of Ternary Crystal Complexes Of Human Dihydrofolate Reductase With Nadph And A Classical Antitumor Furopyrimdine [NCBI NR]
  • gi|230482|pdb|2DHF|B Chain B, Crystal Structures Of Recombinant Human Dihydrofolate Reductase Complexed With Folate And 5-Deazofolate [NCBI NR]
  • gi|230481|pdb|2DHF|A Chain A, Crystal Structures Of Recombinant Human Dihydrofolate Reductase Complexed With Folate And 5-Deazofolate [NCBI NR]
  • gi|229890|pdb|1DRF| Chain , Dihydrofolate Reductase (E.C.1.5.1.3) Complex With Folate [NCBI NR]
  • gi|229861|pdb|1DHF|B Chain B, Crystal Structures Of Recombinant Human Dihydrofolate Reductase Complexed With Folate And 5-Deazofolate [NCBI NR]
  • gi|229860|pdb|1DHF|A Chain A, Crystal Structures Of Recombinant Human Dihydrofolate Reductase Complexed With Folate And 5-Deazofolate [NCBI NR]
  • gi|223651|prf||0905195A reductase,dihydrofolate [NCBI NR]
  • gi|22219058|pdb|1KMV|A Chain A, Human Dihydrofolate Reductase Complexed With Nadph And (Z)- 6-(2-[2,5-Dimethoxyphenyl]ethen-1-Yl)-2,4-Diamino-5- Methylpyrido[2,3-D]pyrimidine (Sri-9662), A Lipophilic Antifolate [NCBI NR]
  • gi|22219057|pdb|1KMS|A Chain A, Human Dihydrofolate Reductase Complexed With Nadph And 6- ([5-Quinolylamino]methyl)-2,4-Diamino-5-Methylpyrido[2,3- D]pyrimidine (Sri-9439), A Lipophilic Antifolate [NCBI NR]
  • gi|157832541|pdb|1OHK|A Chain A, Human Dihydrofolate Reductase, Orthorhombic (P21 21 21) Crystal Form [NCBI NR]
  • gi|157832540|pdb|1OHJ|A Chain A, Human Dihydrofolate Reductase, Monoclinic (P21) Crystal Form [NCBI NR]
  • gi|157831329|pdb|1HFR|A Chain A, Comparison Of Ternary Crystal Complexes Of Human Dihydrofolate Reductase With Nadph And A Classical Antitumor Furopyrimdine [NCBI NR]
  • gi|157830872|pdb|1DRF|A Chain A, Crystal Structure Of Human Dihydrofolate Reductase Complexed With Folate [NCBI NR]
  • gi|146387446|pdb|2C2T|B Chain B, Human Dihydrofolate Reductase Complexed With Nadph And 2,4- Diamino-5-((7,8-Dicarbaundecaboran-7-Yl)methyl)-6- Methylpyrimidine, A Novel Boron Containing, Nonclassical Antifolate [NCBI NR]
  • gi|146387445|pdb|2C2T|A Chain A, Human Dihydrofolate Reductase Complexed With Nadph And 2,4- Diamino-5-((7,8-Dicarbaundecaboran-7-Yl)methyl)-6- Methylpyrimidine, A Novel Boron Containing, Nonclassical Antifolate [NCBI NR]
  • gi|146387444|pdb|2C2S|B Chain B, Human Dihydrofolate Reductase Complexed With Nadph And 2,4- Diamino-5-(1-O-Carboranylmethyl)-6-Methylpyrimidine, A Novel Boron Containing, Nonclassical Antifolate [NCBI NR]
  • gi|146387443|pdb|2C2S|A Chain A, Human Dihydrofolate Reductase Complexed With Nadph And 2,4- Diamino-5-(1-O-Carboranylmethyl)-6-Methylpyrimidine, A Novel Boron Containing, Nonclassical Antifolate [NCBI NR]
  • dihydrofolate reductase pseudogene 1 [HGNC (HUGO)]
  • dihydrofolate reductase [HGNC (HUGO)]
  • (P00374) Dihydrofolate reductase (EC 1.5.1.3) [Swiss-Prot]
  • Chain A, Structure Determination Of Tetrahydroquinazoline Antifoaltes In Complex With Human And Pneumocystis Carinii Dihydrofolate Reductase: Correlations Of Enzyme Selectivity And Stereochemistrygi|47169009|pdb|1S3V|A Chain A, Structure Determination Of [nrdb_11152004_Chlamydomonas]
  • Tax_Id=9606 Dihydrofolate reductase [EBI-IPI_human_3.17_05-09-2006_con_reversed.fasta]
  • Chain A, Human Dihydrofolate Reductase, Orthorhombic (P21 21 21) Crystal Form [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Chain A, Human Dihydrofolate Reductase, Monoclinic (P21) Crystal Form [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Chain A, Comparison Of Ternary Crystal Complexes Of Human Dihydrofolate Reductase With Nadph And A Classical Antitumor Furopyrimdine [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Chain A, Crystal Structure Of Human Dihydrofolate Reductase Complexed With Folate [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Chain B, Human Dihydrofolate Reductase Complexed With Nadph And 2,4- Diamino-5-((7,8-Dicarbaundecaboran-7-Yl)methyl)-6- Methylpyrimidine, A Novel Boron Containing, Nonclassical Antifolate [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Chain A, Human Dihydrofolate Reductase Complexed With Nadph And 2,4- Diamino-5-((7,8-Dicarbaundecaboran-7-Yl)methyl)-6- Methylpyrimidine, A Novel Boron Containing, Nonclassical Antifolate [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Chain B, Human Dihydrofolate Reductase Complexed With Nadph And 2,4- Diamino-5-(1-O-Carboranylmethyl)-6-Methylpyrimidine, A Novel Boron Containing, Nonclassical Antifolate [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Chain A, Human Dihydrofolate Reductase Complexed With Nadph And 2,4- Diamino-5-(1-O-Carboranylmethyl)-6-Methylpyrimidine, A Novel Boron Containing, Nonclassical Antifolate [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Chain A, Solution Structure Of Human Dihydrofolate Reductase Complexed With Trimethoprim And Nadph, 25 Structures [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Chain A, Understanding The Role Of Leu22 Variants In Methotrexate Resistance: Comparison Of Wild-Type And Leu22arg Variant Mouse And Human Dihydrfolate Reductase Ternary Crystal Complexes With Methotrexate And Nadph [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Chain A, Structure Determination Of Tetrahydroquinazoline Antifoaltes In Complex With Human And Pneumocystis Carinii Dihydrofolate Reductase: Correlations Of Enzyme Selectivity And Stereochemistry [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Chain A, Structure Determination Of Tetrahydroquinazoline Antifolates In Complex With Human And Pneumocystis Carinii Dihydrofolate Reductase: Correlations Of Enzyme Selectivity And Stereochemistry [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Chain A, Analysis Of Three Crystal Structure Determinations Of A 5- Methyl-6-N-Methylanilino Pyridopyrimidine Antifolate Complex With Human Dihydrofolate Reductase [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Chain A, Human Dihydrofolate Reductase Complexed With Nadph And (Z)- 6-(2-[2,5-Dimethoxyphenyl]ethen-1-Yl)-2,4-Diamino-5- Methylpyrido[2,3-D]pyrimidine (Sri-9662), A Lipophilic Antifolate [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Chain A, Human Dihydrofolate Reductase Complexed With Nadph And 6- ([5-Quinolylamino]methyl)-2,4-Diamino-5-Methylpyrido[2,3- D]pyrimidine (Sri-9439), A Lipophilic Antifolate [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Chain B, Crystal Structures Of Recombinant Human Dihydrofolate Reductase Complexed With Folate And 5-Deazofolate [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Chain A, Crystal Structures Of Recombinant Human Dihydrofolate Reductase Complexed With Folate And 5-Deazofolate [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • reductase,dihydrofolate [NCBI-RefSeq_human_na_08-16-2008_con_reversed.fasta]
  • Chain B, Dihydrofolate Reductase (E.C.1.5.1.3) (DHFR) Complex With 5-Deazafolate [nr-271106-contam.fasta]
  • Chain , Human Dihydrofolate Reductase, Monoclinic (P21) Crystal Form [nr-271106-contam.fasta]
  • Chain B, Dihydrofolate Reductase (E.C.1.5.1.3) (DHFR) Complex With Folate [nr-271106-contam.fasta]
  • Chain A, Dihydrofolate Reductase (E.C.1.5.1.3) (DHFR) Complex With 5-Deazafolate [nr-271106-contam.fasta]
  • Chain , Human Dihydrofolate Reductase, Orthorhombic (P21 21 21) Crystal Form [nr-271106-contam.fasta]
  • Chain , Dihydrofolate Reductase (E.C.1.5.1.3) Complex With Folate [nr-271106-contam.fasta]
  • Chain , Comparison Of Ternary Crystal Complexes Of Human Dihydrofolate Reductase With Nadph And A Classical Antitumor Furopyrimdine [nr-271106-contam.fasta]
  • Chain A, Dihydrofolate Reductase (E.C.1.5.1.3) (DHFR) Complex With Folate [nr-271106-contam.fasta]
    • Organism: Homo sapiens
    Length: 186 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VGSLNCIVAV SQNMGIGKNG DLPWPPLRNE FRYFQRMTTT SSVEGKQNLV IMGKKTWFSI  60
   61 PEKNRPLKGR INLVLSRELK EPPQGAHFLS RSLDDALKLT EQPELANKVD MVWIVGGSSV 120
  121 YKEAMNHPGH LKLFVTRIMQ DFESDTFFPE IDLEKYKLLP EYPGVLSDVQ EEKGIKYKFE 180
  181 VYEKND

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Noble WS, et al. (2009) Manuscript in preparation. DHFRP1, DHFR gi|112491310

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..186] PSI-BLAST 56.522879 No description for 2fzjA was found.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle