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Protein Overview: Cha-PA

General Information:
Name(s) found: Cha-PA / FBpp0088397 [FlyBase]
Description(s) found:
Found 21 descriptions.
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  • The gene Choline acetyltransferase is referred to in FlyBase by the symbol Dmel\Cha (CG12345, FBgn0000303). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:14531245..14558068. It has the cytological map location 91C1-91C5. There is experimental evidence that it has the molecular function</span>: choline O-acetyltransferase activity. There is experimental evidence that it is involved in the biological process</span>: neuromuscular synaptic transmission. 32 alleles are reported. The phenotype of these alleles is annotated with: dorsal medial muscle. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 721 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: acetylcholine biosynthetic process [NAS][TAS]
    neuromuscular synaptic transmission [IMP]
    Molecular Function: choline O-acetyltransferase activity [IDA][ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MASNEASTSA AGSGPESAAL FSKLRSFSIG SGPNSPQRVV SNLRGFLTHR LSNITPSDTG  60
   61 WKDSILSIPK KWLSTAESVD EFGFPDTLPK VPVPALDETM ADYIRALEPI TTPAQLERTK 120
  121 ELIRQFSAPQ GIGARLHQYL LDKREAEDNW AYYYWLNEMY MDIRIPLPIN SNPGMVFPPR 180
  181 RFKTVHDVAH FAARLLDGIL SHREMLDSGE LPLERAASRE KNQPLCMAQY YRLLGSCRRP 240
  241 GVKQDSQFLP SRERLNDEDR HVVVICRNQM YCVVLQASDR GKLSESEIAS QILYVLSDAP 300
  301 CLPAKPVPVG LLTAEPRSTW ARDREMLQED ERNQRNLELI ETAQVVLCLD EPLAGNFNAR 360
  361 GFTGATPTVH RAGDRDETNM AHEMIHGGGS EYNSGNRWFD KTMQLIICTD GTWGLCYEHS 420
  421 CSEGIAVVQL LEKIYKKIEE HPDEDNGLPQ HHLPPPERLE WHVGPQLQLR FAQASKSVDK 480
  481 CIDDLDFYVY RYQSYGKTFI KSCQVSPDVY IQLALQLAHY KLYGRLVATY ESASTRRFLH 540
  541 GRVDCIRAAS TEALEWAKAM CQGEGANVPL ESDREDEEES RKVKFSIYSK DHLRELFRCA 600
  601 VARQTEVMVK NILGNGIDIP LLGLREASIE VTGEMHELFK DESYIISQCF LLSTSQVACS 660
  661 TDSFMGYGPV TPRGYGCSYN PHPEQIVFCV SAFYSCEDTS ASRYAKSLQD SLDIMRDLLQ 720
  721 N

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..721] PSI-BLAST 1000.0 Crystal structure of rat choline acetyltransferase

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • carnitine O-acyltransferase activity
    		•  7.54616819269984 bayes_pls_golite062009
  • carnitine O-acetyltransferase activity
    		•  7.38318207912192 bayes_pls_golite062009
  • choline O-acetyltransferase activity
    		•  6.09272417016149 bayes_pls_golite062009
  • octanoyltransferase activity
    		•  4.52268776339565 bayes_pls_golite062009
  • O-octanoyltransferase activity
    		•  4.52268776339565 bayes_pls_golite062009
  • carnitine O-octanoyltransferase activity
    		•  4.52268776339565 bayes_pls_golite062009
  • S-acyltransferase activity
    		•  4.44987112475286 bayes_pls_golite062009
  • carnitine O-palmitoyltransferase activity
    		•  3.83467723502092 bayes_pls_golite062009
  • O-palmitoyltransferase activity
    		•  3.83467723502092 bayes_pls_golite062009
  • transferase activity, transferring acyl groups
    		•  3.7327637835604 bayes_pls_golite062009
  • O-acyltransferase activity
    		•  3.7101056995294 bayes_pls_golite062009
  • dihydrolipoamide S-acyltransferase activity
    		•  3.56004160262054 bayes_pls_golite062009
  • dihydrolipoyllysine-residue acetyltransferase activity
    		•  3.36143851730669 bayes_pls_golite062009
  • S-acetyltransferase activity
    		•  3.32990830846882 bayes_pls_golite062009
  • acyltransferase activity
    		•  3.08588280042054 bayes_pls_golite062009
  • transferase activity, transferring acyl groups other than amino-acyl groups
    		•  3.027770031317 bayes_pls_golite062009
  • S-succinyltransferase activity
    		•  3.02354522717247 bayes_pls_golite062009
  • dihydrolipoyllysine-residue succinyltransferase activity
    		•  3.02354522717247 bayes_pls_golite062009
  • O-acetyltransferase activity
    		•  2.37098434941789 bayes_pls_golite062009
  • palmitoyltransferase activity
    		•  2.23754077046213 bayes_pls_golite062009
  • succinyltransferase activity
    		•  2.08404693277798 bayes_pls_golite062009
  • choline binding
    		•  1.59193088660278 bayes_pls_golite062009
  • catalytic activity
    		•  1.51562638409295 bayes_pls_golite062009
  • binding
    		•  1.42888906064321 bayes_pls_golite062009
  • acetyltransferase activity
    		•  1.12787027896966 bayes_pls_golite062009
  • transferase activity
    		•  1.08341671157927 bayes_pls_golite062009
  • pyruvate dehydrogenase activity
    		•  0.85838145786229 bayes_pls_golite062009
  • protein binding
    		•  0.104367069798378 bayes_pls_golite062009
  • amine binding
    		•  0.0679262278252373 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.72

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle