Protein Overview: HMGCL_ARATH

General Information:
Name(s) found:	HMGCL_ARATH [Swiss-Prot]
Description(s) found: SHOW ONLY BEST	gi\|20197286\|gb\|AAC32247.2\| putative hydroxymethylglutaryl-CoA lyase [Arabidopsis thaliana] [NCBI NR] gi\|18401240\|ref\|NP_565629.1\| hydroxymethylglutaryl-CoA lyase, putative / 3-hydroxy-3-methylglutarate-CoA lyase, putative / HMG-CoA lyase, putative [Arabidopsis thaliana] [NCBI NR] gi\|13194812\|gb\|AAK15568.1\|AF349521_1 putative hydroxymethylglutaryl-CoA lyase [Arabidopsis thaliana] [NCBI NR] gi\|11935189\|gb\|AAG42010.1\|AF327420_1 putative hydroxymethylglutaryl-CoA lyase [Arabidopsis thaliana] [NCBI NR] Hydroxymethylglutaryl-CoA lyase, mitochondrial OS=Arabidopsis thaliana GN=HMGCL PE=1 SV=2 [Swiss-Prot] (O81027) Putative hydroxymethylglutaryl-CoA lyase [athaliana3702.FASTAC.txt] putative hydroxymethylglutaryl-CoA lyase [Arabidopsis thaliana]gi\|11935189\|gb\|AAG42010.1\| putative hydroxymethylglutaryl-CoA lyase [Arabidopsis thaliana]gi\|20197286\|gb\|AAC32247.2\| putative hydroxymethylglutaryl-CoA lyase [Arabidopsis thaliana]gi\|184012 [nrdb_11152004_Chlamydomonas] Tax_Id=3702 Hydroxymethylglutaryl-CoA lyase [EBI-IPI_Arabidopsis_3.11_12-06-2005_reversed.fasta] \| Symbols: \| hydroxymethylglutaryl-CoA lyase, putative / 3-hydroxy-3-methylglutarate-CoA lyase, putative / HMG-CoA lyase, putative \| chr2:11436270-11439368 REVERSE [TAIR_Arabidopsis_na_04-12-2008_con_reversed.fasta] putative hydroxymethylglutaryl-CoA lyase [Arabidopsis thaliana] [nr-271106-contam.fasta] catalytic/ hydroxymethylglutaryl-CoA lyase [Arabidopsis thaliana] [nr-271106-contam.fasta] \| Symbols: \| Aldolase superfamily protein \| chr2:11429192-11432290 REVERSE LENGTH=468 [TAIR_A_Thaliana_10_12-14-2010_reversed.fasta]
Organism:	Arabidopsis thaliana
Length:	468 amino acids
Gene Ontology:
Cellular Component:	mitochondrion [IDA]
Biological Process:	metabolic process [IEA] leucine metabolic process [ISS]
Molecular Function:	catalytic activity [IEA] hydroxymethylglutaryl-CoA lyase activity [ISS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQWNGVRRAH SIWCKRLTNN THLHHPSIPV SHFFTMSSLE EPLSFDKLPS MSTMDRIQRF  60
   61 SSGACRPRDD VGMGHRWIEG RDCTTSNSCI DDDKSFAKES FPWRRHTRKL SEGEHMFRNI 120
  121 SFAGRTSTVS GTLRESKSFK EQKYSTFSNE NGTSHISNKI SKGIPKFVKI VEVGPRDGLQ 180
  181 NEKNIVPTSV KVELIQRLVS SGLPVVEATS FVSPKWVPQL ADAKDVMDAV NTLDGARLPV 240
  241 LTPNLKGFQA AVSAGAKEVA IFASASESFS LSNINCTIEE SLLRYRVVAT AAKEHSVPVR 300
  301 GYVSCVVGCP VEGPVLPSKV AYVVKELYDM GCFEISLGDT IGIGTPGSVV PMLEAVMAVV 360
  361 PADKLAVHFH DTYGQALANI LVSLQMGISI VDSSIAGLGG CPYAKGASGN VATEDVVYML 420
  421 NGLGVHTNVD LGKLIAAGDF ISKHLGRPNG SKAAVALNRR ITADASKI

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..159]	MSA	1.071981	View MSA. No confident structure predictions are available.
2	View Details	[160..468]	PSI-BLAST	92.69897	Crystal Structure of Human HMG-CoA Lyase: Insights into Catalysis and the Molecular Basis for Hydroxymethylglutaric Aciduria

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.92

Protein Overview: HMGCL_ARATH

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: