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Catalysis of the cleavage of a C-C bond by other means than by hydrolysis or oxidation, of a 3-hydroxy acid. Catalysis of the cleavage of C-C bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. Catalysis of the reaction: (S)-3-hydroxy-3-methylglutaryl-CoA = acetyl-CoA + acetoacetate.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: hydroxymethylglutaryl-CoA lyase activity
Acc: GO:0004419
Aspect: Molecular Function
Desc: Catalysis of the reaction: (S)-3-hydroxy-3-methylglutaryl-CoA = acetyl-CoA + acetoacetate.
Synonyms:
  • HMG-CoA lyase activity
  • (S)-3-hydroxy-3-methylglutaryl-CoA acetoacetate-lyase activity
  • hydroxymethylglutaryl coenzyme A lyase activity
  • 3-hydroxy-3-methylglutarate-CoA lyase activity
  • 3-hydroxy-3-methylglutaryl-CoA lyase activity
  • (S)-3-hydroxy-3-methylglutaryl-CoA acetoacetate-lyase (acetyl-CoA-forming)
  • hydroxymethylglutaryl coenzyme A-cleaving enzyme
  • 3-hydroxy-3-methylglutaryl CoA cleaving enzyme
  • 3-hydroxy-3-methylglutaryl coenzyme A lyase activity
Proteins in PDR annotated with:
   This term: 10 [Search]
   Term or descendants: 10 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0004419 - hydroxymethylglutaryl-CoA lyase activity (interactive image map)
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