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Protein Overview: mlh-1

General Information:
Name(s) found: mlh-1 / CE35190 [WormBase]
Description(s) found:
Found 15 descriptions.
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  • WBGene00003373 locus:mlh-1 status:Confirmed UniProt:Q9XU10 protein_id:CAB07283.2 [WormBase]
    • Organism: Caenorhabditis elegans
    Length: 758 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IEALink to PubMed article]
    Biological Process: DNA repair [IMPLink to PubMed article]
    mismatch repair [IEALink to PubMed article]
    Molecular Function: ATP binding [IEALink to PubMed article]
    mismatched DNA binding [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGLIQRLPQD VVNRMAAGEV LARPCNAIKE LVENSLDAGA TEIMVNMQNG GLKLLQVSDN  60
   61 GKGIEREDFA LVCERFATSK LQKFEDLMHM KTYGFRGEAL ASLSHVAKVN IVSKRADAKC 120
  121 AYQANFLDGK MTADTKPAAG KNGTCITATD LFYNLPTRRN KMTTHGEEAK MVNDTLLRFA 180
  181 IHRPDVSFAL RQNQAGDFRT KGDGNFRDVV CNLLGRDVAD TILPLSLNST RLKFTFTGHI 240
  241 SKPIASATAA IAQNRKTSRS FFSVFINGRS VRCDILKHPI DEVLGARQLH AQFCALHLQI 300
  301 DETRIDVNVH PTKNSVIFLE KEEIIEEIRA YFEKVIGEIF GFEALDVEKP EEEQPDIENL 360
  361 VMIPMSQSLK SIEAIRKPDT KPEFKSSPSA WKSDKKRVDY MEVRTDAKER KIDEFVTRGG 420
  421 AVGPTTSNDD IFGGSGILKR ARTEDSTGGE KEPEDLNTDF DDVSMVSLVS TADGRRLNES 480
  481 QDLGEDDDVD FEYGKTHREF HFESIEVLRK EIIANSSQSL REMFKTSTFV GSINVKQVLI 540
  541 QFGTSLYHLD FSTVLREFFY QISVFSFGNY GSYRLDEEPP AIIEILELLG ELSTREPNYA 600
  601 AFEVFANVEN RFAAEKLLAE HADLLHDYFA IKLDQLENGR LHITEIPSLV HYFVPQLEKL 660
  661 PFLIATLVLN VDYDDEQNTF RTICRAIGDL FTLDTNFITL DKKISAFSAT PWKTLIKEVL 720
  721 MPLVKRKFIP PEHFKQAGVI RQLADSHDLY KVFERCGT

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..192] PSI-BLAST 85.69897 DNA mismatch repair protein MutL
    2 View Details [193..579] PSI-BLAST 22.0 No description for 2cgeA was found.
    3 View Details [580..758] MSA 1.394962 View MSA. No confident structure predictions are available.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle