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Protein Overview: nuo-5

General Information:
Name(s) found: nuo-5 / CE33341 [WormBase]
Description(s) found:
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  • WBGene00021562 locus:nuo-5 status:Partially_confirmed UniProt:Q86S77 protein_id:CCD65493.1 [WormBase]
  • gi|32566231|ref|NP_872121.1| NADH Ubiquinone Oxidoreductase family member (nuo-5) [Caenorhabditis elegans] [NCBI NR]
  • gi|27885023|gb|AAO25977.1| Nadh ubiquinone oxidoreductase protein 5, isoform c [Caenorhabditis elegans] [NCBI NR]
  • [wormpep104.fasta]
  • CE33341 WBGene00021562 locus:nuo-5 status:Partially_confirmed TR:Q86S77 protein_id:AAO25977.1 [wormpep150.fasta]
  • 33341 WBGene00021562 status:Partially_confirmed TR:Q86S77 protein_id:AAO25977.1 [wormpep130-phg-ecoli-orf-rand.fasta]
  • ferredoxin and Molybdopterin oxidoreductase (5D185C) [Caenorhabditis elegans]gi|27885023|gb|AAO25977.1| Hypothetical protein Y45G12B.1c [Caenorhabditis elegans] [nrdb_11152004_Chlamydomonas]
  • CE33341 WBGene00021562 status:Partially_confirmed TR:Q86S77 protein_id:AAO25977.1 [wormpep132.fasta]
  • 33341 WBGene00021562 locus:nuo-5 status:Partially_confirmed TR:Q86S77 protein_id:AAO25977.1 [wormpep150-phg-orf-ecoli-rand.fasta]
  • status:Partially_confirmed TR:Q86S77 protein_id:AAO25977.1 [wormpep115.fasta.reversed]
  • CE33341 WBGene00021562 locus:nuo-5 status:Partially_confirmed UniProt:Q86S77_CAEEL protein_id:AAO25977.1 [WormBase_C-elegans_193_07-31-2008_con_reversed.fasta]
  • CE33341 WBGene00021562 locus:nuo-5 status:Partially_confirmed UniProt:Q86S77_CAEEL protein_id:AAO25977.1| [wormORF-contam.fasta]
  • Hypothetical protein Y45G12B.1c [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • NADH Ubiquinone Oxidoreductase family member (nuo-5) [Caenorhabditis elegans] [nr-271106-contam.fasta]
  • CE33341 WBGene00021562 locus:nuo-5 status:Partially_confirmed UniProt:Q86S77 protein_id:AAO25977.1 [wormbase_c-elegans_2.11_01-10-2010_reversed.fasta]
  • [wormpep210-phg-orf-LaDeana-ecoli-contam.fasta.nr]
  • CE33341 WBGene00021562 locus:nuo-5 status:Partially_confirmed UniProt:Q86S77 protein_id:CCD65493.1 [wormbase_c_elegans_ws231_03-13-2012_reversed.fasta]
  • Isoform of Q9N4Y8, NADH Ubiquinone Oxidoreductase OS=Caenorhabditis elegans GN=nuo-5 PE=1 SV=1 [CAEEL.fasta.20160308]
    • Organism: Caenorhabditis elegans
    Length: 634 amino acids

    Gene Ontology:
    Cellular Component: membrane [IEALink to PubMed article]
    formate dehydrogenase complex [IEALink to PubMed article]
    Biological Process: electron transport [IEALink to PubMed article]
    nematode larval development [IMPLink to PubMed article]
    positive regulation of growth rate [IMPLink to PubMed article]
    embryonic development ending in birth or egg hatching [IMPLink to PubMed articleLink to PubMed article]
    ATP synthesis coupled electron transport [IEALink to PubMed article]
    formate metabolic process [IEALink to PubMed article]
    growth [IMPLink to PubMed article]
    Molecular Function: oxidoreductase activity [IEALink to PubMed article]
    electron carrier activity [IEALink to PubMed article]
    molybdenum ion binding [IEALink to PubMed article]
    NADH dehydrogenase (ubiquinone) activity [IEALink to PubMed article]
    formate dehydrogenase activity [IEALink to PubMed article]
    dimethyl sulfoxide reductase activity [IEALink to PubMed article]
    oxidoreductase activity, acting on NADH or NADPH [IEALink to PubMed article]
    4 iron, 4 sulfur cluster binding [IEALink to PubMed article]
    iron-sulfur cluster binding [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MHRVGGQIVR GVSKAQQKRS LSVAAPAPPK KVEVFIDDKK VLVDPGMTIL QACALVGVDI  60
   61 PRFCYHDRLS IAGNCRMCLV EVEKSVKPVA SCAMPVMNGM KVKTNSDFVK KAREGVMEFM 120
  121 LNNHPLDCPI CDQGGECDLQ DQAMNFGSDR GRLQSRFDGK RALEDKNIGP LVKTVMTRCI 180
  181 QCTRCVRFAN EVAAFPDFGT TGRGQDLQIG TYVEKFFASE LSGNIIDICP VGALTSKQYA 240
  241 FTARPWETRK TESVDVMDAT GSNIVLSHRT GELLRVIPKI NDDINEEWIG DQSRFAVDGL 300
  301 KVQRLLTPMI RGADGQLKPA TWEEALFTVA AKLRETPAEQ KAAVAGGLND VESLVALKDL 360
  361 FNRFNSENVM TEEEFPDVGS GGSDLRSNYV FNDGIASVEN ADAILLVGTN PRFEAPTLNA 420
  421 RIRKSFLYSD VQVGVIGAET ELTYEYDYLG ASAKAIDEIL AGKGDFAKIL SSATTPLIIV 480
  481 GAQALKGEAG AALLGKLQQL ADKLGSGKEV KVLNVLQRWA GQAGALDVGY KAGTAGIRKT 540
  541 PIKFLYLLGA DEGKVTKANL DPSAFVVYQG HHGDAGAEMA DVVLPGAAYT EKEGTYVNTE 600
  601 GRSQRCASGK AKKKLDLSIF WQRKSNNFGF FQRK

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..634] PSI-BLAST 96.0 Crystal structure of the hydrophilic domain of respiratory complex I from Thermus thermophilus

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • oxidoreductase activity
    		•  3.42905611129045 bayes_pls_golite062009
  • electron carrier activity
    		•  2.29892126091131 bayes_pls_golite062009
  • succinate dehydrogenase activity
    		•  2.17392875467497 bayes_pls_golite062009
  • oxidoreductase activity, acting on NADH or NADPH
    		•  2.00026555763397 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-CH group of donors
    		•  1.9389275936249 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-NH group of donors, quinone or similar compound as acceptor
    		•  1.87673954208357 bayes_pls_golite062009
  • formate dehydrogenase activity
    		•  1.34526518541816 bayes_pls_golite062009
  • NADH dehydrogenase (ubiquinone) activity
    		•  1.22033162240751 bayes_pls_golite062009
  • NADH dehydrogenase activity
    		•  1.11412439147941 bayes_pls_golite062009
  • binding
    		•  0.689656573625534 bayes_pls_golite062009
  • 4 iron, 4 sulfur cluster binding
    		•  0.628123949302495 bayes_pls_golite062009
  • iron-sulfur cluster binding
    		•  0.5629744057246 bayes_pls_golite062009
  • metal cluster binding
    		•  0.5629744057246 bayes_pls_golite062009
  • oxidoreduction-driven active transmembrane transporter activity
    		•  0.300439488774121 bayes_pls_golite062009
  • catalytic activity
    		•  0.105119876745552 bayes_pls_golite062009
  • NADH dehydrogenase (quinone) activity
    		•  0.0921104166364124 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle