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Protein Overview: fum-1

General Information:
Name(s) found: fum-1 / CE32457 [WormBase]
Description(s) found:
Found 18 descriptions.
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  • WBGene00001503 locus:fum-1 status:Confirmed UniProt:Q8ITZ0 protein_id:CCD72342.1 [WormBase]
    • Organism: Caenorhabditis elegans
    Length: 328 amino acids

    Gene Ontology:
    Cellular Component: tricarboxylic acid cycle enzyme complex [IEALink to PubMed article]
    Biological Process: purine ribonucleotide biosynthetic process [IEALink to PubMed article]
    protocatechuate catabolic process [IEALink to PubMed article]
    positive regulation of growth rate [IMPLink to PubMed articleLink to PubMed article]
    embryonic development ending in birth or egg hatching [IMPLink to PubMed articleLink to PubMed article]
    arginine biosynthetic process via ornithine [IEALink to PubMed article]
    aspartate metabolic process [IEALink to PubMed article]
    fumarate metabolic process [IEALink to PubMed article]
    reproduction [IMPLink to PubMed article]
    Molecular Function: N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity [IEALink to PubMed article]
    3-carboxy-cis,cis-muconate cycloisomerase activity [IEALink to PubMed article]
    catalytic activity [IEALink to PubMed article]
    aspartate ammonia-lyase activity [IEALink to PubMed article]
    argininosuccinate lyase activity [IEALink to PubMed article]
    fumarate hydratase activity [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSQSSNDTFP TAMHIAVGRE VNSRLLPALK KLRTALHNKA EEFKDIIKIG RTHTQDAVPL  60
   61 TLGQEFSAYV TQLDNSIARV ESTLPRLYQL AAGGTAVGTG LNTRKGFAEK VAATVSELTG 120
  121 LPFVTAPNKF EALAAHDALV EVHGALNTVA VSFMKIGNDI RFLGSGPRCG LGELSLPENE 180
  181 PGSSIMPGKV NPTQCEAITM VAAQVMGNQV AVSVGGSNGH FELNVFKPLI VRNVLQSTRL 240
  241 LADSAVSFTD HCVDGIVANK DNIAKIMRES LMLVTALNPH IGYDNAAKIA KTAHKNGTTL 300
  301 VQEAVKLGIL TEEQFAQWVK PENMLGPK

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..328] PSI-BLAST 112.0 RECOMBINANT YEAST FUMARASE

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • catalytic activity
    		•  1.9827639291126 bayes_pls_golite062009
  • lyase activity
    		•  1.35645816892052 bayes_pls_golite062009
  • carbon-nitrogen lyase activity
    		•  0.354118027765201 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle