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Protein Overview: nhx-4

General Information:
Name(s) found: nhx-4 / CE30951 [WormBase]
Description(s) found:
Found 20 descriptions.
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  • WBGene00003732 locus:nhx-4 Sodium\/hydrogen exchanger status:Confirmed UniProt:G5EDU2 protein_id:CCD64771.1 [WormBase]
    • Organism: Caenorhabditis elegans
    Length: 749 amino acids

    Gene Ontology:
    Cellular Component: integral to membrane [IEALink to PubMed article]
    Biological Process: sodium ion transport [IEALink to PubMed article]
    embryonic development ending in birth or egg hatching [IMPLink to PubMed article]
    regulation of pH [IEALink to PubMed article]
    Molecular Function: solute:hydrogen antiporter activity [IEALink to PubMed article]
    sodium:hydrogen antiporter activity [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRSQKTLLVI LTLLLSYNVF CTGDTNGTLA QDPADQLLNT VPENFTNNIE YPQNNNNNTS  60
   61 ETDESMDAEG EWVQSAPPEE IEEAKHLLDP VHVDFEHTHK PLAFVFLIIL VTLAKPTLHW 120
  121 PVLRKLPESV VLMLYGVLMA TAVKALMRID PGQLDTFMFF MILLPAIVND AGLSMQKKEF 180
  181 TIALPKILLF AVVGTVVHAL LLAATMYGIE PIFSFKPGFL HLFVFATLIS AVDPVSVLST 240
  241 FAELDVKKSL FILIFGESLC NDAVTIVLYR TSINVIKTSD ASDEMLTITS VVGSCVVQFM 300
  301 IVCGFGLLCG AVVGFAGVFI MKNMVGHQMN QPIFQLFCPY LAYLLAETGH YSGILASILC 360
  361 AAIMSYYMAA NMCVEMEFAA FTFSKTGSSL SESCIFFYLG VSLVSYNHEF DFYFIAVTVF 420
  421 CCTLYRFLVT CTLSAFYNLF ASEKNRIPFT DQLVVTHAGI RGAVCFGLVQ IIDERIIPAK 480
  481 PYFVTTTLAM IFVTSILQGC TIKFVMKCLK IPGDDGTKQK DPKALRWLTH LNDKYIKKFL 540
  541 VSENTYLPTD ETFRNLGLPK AVSTALRIGE RSHTDLQRHG EVSHTPAPSV GRPTIAPFDF 600
  601 GNMEEENNRL PSTGRRTPVA RSQTRYSRHF IYAIPNETDN YLTCPVSASK RPPFDPSQVY 660
  661 QHQNTISNPG DDRARCYNRR HNSMSGADEM ELKQLNQTVQ KKLSRTITSG TKQFVVNPDE 720
  721 AIREESPATI PKKRATFEDD EISKIDESE

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..87] deduced N/A No confident structure predictions are available.
    2 View Details [88..579] PSI-BLAST 7.39794 Cytochrome O ubiquinol oxidase, subunit I
    3 View Details [580..749] MSA 2.625991 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • hydrogen ion transmembrane transporter activity
    		•  6.67219472356299 bayes_pls_golite062009
  • monovalent inorganic cation transmembrane transporter activity
    		•  5.36696570788676 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  4.97293291274237 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  4.88027604120114 bayes_pls_golite062009
  • inorganic cation transmembrane transporter activity
    		•  4.56139688972524 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  4.48195996846249 bayes_pls_golite062009
  • transporter activity
    		•  3.02642879486966 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  2.89692543447799 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  2.65243944674297 bayes_pls_golite062009
  • binding
    		•  0.679485348721049 bayes_pls_golite062009
  • protein binding
    		•  0.358081002328109 bayes_pls_golite062009
  • heme-copper terminal oxidase activity
    		•  0.240598645883604 bayes_pls_golite062009
    3 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle