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Protein Overview: dhp-1

General Information:
Name(s) found: dhp-1 / CE30293 [WormBase]
Description(s) found:
Found 22 descriptions.
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  • WBGene00000963 locus:dhp-1 Dihydropyrimidinase 1 status:Confirmed UniProt:Q21773 protein_id:CAD24483.1 [WormBase]
    • Organism: Caenorhabditis elegans
    Length: 489 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    Biological Process: pyrimidine base catabolic process [IDALink to PubMed article]
    nucleobase catabolic process [ISSLink to PubMed article]
    Molecular Function: hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides [IDALink to PubMed article]
    dihydropyrimidinase activity [ISSLink to PubMed article]
    hydrolase activity [IEALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSPPLVIKNG TVVNEDGMFK ADVLVRNGII VEVSPNITAL PDTEVIDATD RLVIPGGIDP  60
   61 HTHMQMPYMG EVTKDDFLKG TEAAVAGGTT MIIDFCCPDH RNGESLIAGY NRWRSWADPK 120
  121 VCCDYGLSVA ITMWRPETAE QMAIITSPEF GVNSFKFYMA YENTLMVRDD ELFRGMQECA 180
  181 KLRALARVHC ENGSVIKEKE IDLLAKGVTG PEGHTQSRPE EIEAEATNRA CVLAAQANCP 240
  241 VYIVHVMTKG AASAISHHRA QGSIVFGEPI AAGLALDGSH YYNEDWLHAA RYVMSPPLSR 300
  301 DPTTPELLMK LLAAGELHLT GTDNCTYDCR QKSLGKGNFT KIPNGINGVE DRMSVVWEKG 360
  361 VHSGIIDPMR YVSITSSTAA KIFNIYPRKG RIAVGSDADI VIFNPNATRT ISKDTHHHNL 420
  421 DFNIFEGINC HGVAEVTISR GRIVWAHGKL QTVPGSGKFI PLLANSPFVF STHEKREQKI 480
  481 QPRIVERLE

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..489] PSI-BLAST 98.69897 No description for 2ftwA was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • dihydropyrimidinase activity
    		•  4.17779750769842 bayes_pls_golite062009
  • uracil binding
    		•  2.6045173443981 bayes_pls_golite062009
  • pyrimidine binding
    		•  2.6045173443981 bayes_pls_golite062009
  • hydrolase activity
    		•  2.54288207838687 bayes_pls_golite062009
  • allantoinase activity
    		•  2.45571277189844 bayes_pls_golite062009
  • dihydroorotase activity
    		•  2.32070383330692 bayes_pls_golite062009
  • hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
    		•  2.20489529944693 bayes_pls_golite062009
  • deaminase activity
    		•  1.79186203771221 bayes_pls_golite062009
  • catalytic activity
    		•  1.70199291046899 bayes_pls_golite062009
  • hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
    		•  1.60895003474033 bayes_pls_golite062009
  • adenine deaminase activity
    		•  1.4081199504179 bayes_pls_golite062009
  • thymine binding
    		•  1.34528530211689 bayes_pls_golite062009
  • hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
    		•  0.573107361273483 bayes_pls_golite062009
  • binding
    		•  0.568044210518453 bayes_pls_golite062009
  • guanine deaminase activity
    		•  0.134430884998957 bayes_pls_golite062009
  • purine nucleoside binding
    		•  0.015278392159201 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle